Navigation Links
Redox-active iron is a sensor of cognitive impairment associated with Alzheimer's disease
Date:4/4/2008

d with AD may represent a terminal situation, whereby the central nervous system attempts to minimize iron-associated toxicity.

A possible mechanism to explain the decrease of redox-active CSF iron during the course of the disease could be the sequestration of this metal by the aggregation of a brain component called amyloid peptides (A) into the senile plaques, anomalous structures where cumulative iron has been found. High redox-active CSF iron levels could increase the production of the amyloid- protein precursor (APP) in the neuronal membrane, while the soluble form of APP (A peptide) could act as an iron chelator promoting A peptides aggregation into the senile plaques. The suggested mechanism could represent a homeostatic process by the brain that fights to reduce the cascade of cellular insults in AD, in order to regulate the CSF iron levels and its toxicity. These findings indicate that the decrease in redox-active CSF iron may correspond to a final late effort by brain cells to decrease oxidative stress mediated by iron.

This discovery offers the possibility to monitor iron levels in the CSF in relation with cognitive impairment and perhaps be used as part of a battery of biomarkers for an early diagnosis of these disorders, thus facilitating the appropriate treatment to patients and increasing their quality of life.


'/>"/>

Contact: Astrid Engelen
a.engelen@iospress.nl
31-206-883-355
IOS Press
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Discovery of sugar sensor in intestine could benefit diabetes
2. Biosensors to probe the metals menace
3. Leading-edge body sensor could help produce sporting champions
4. Tiny Sensor Could Spot Cancer Early
5. Area deep within the brain found to play role in sensory perception
6. Study Offers Insights Into Sensory Perceptions
7. GainSpan Unveils Wi-Fi(R) Sensor Network Solution With Years of Battery Life
8. Biometric sensors no dirtier than doorknobs, study finds
9. Scientists Spot Eyes Motion Sensors
10. Space sensors shed new light on air quality
11. Investigating causes of asthma attacks: New sensor system monitors environmental exposure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... 2014 Recently, Dylan Queen, a famous ... released its collection of discounted prom dresses, most of ... senior spokesman of the company, the promotion is valid ... is to expand the UK market. , The prom ... colors, lengths, and styles: A-line strapless, empire strapless chiffon, ...
(Date:12/25/2014)... California (PRWEB) December 25, 2014 Helen ... home in Woodland Hills, California after an 8 year ... away on Christmas Eve evening in her home in ... aggressive metastatic breast cancer. , As ... over forty years, she pioneered and championed many of ...
(Date:12/25/2014)... 25, 2014 (HealthDay News) -- The risk of burns ... so you need to be extra cautious, an expert ... see a significant increase in patients coming in with ... Suffolk County Volunteer Firefighters Burn Center of Stony Brook ... be full of joy, but if not careful, could ...
(Date:12/25/2014)... (PRWEB) December 25, 2014 AngelWeddingDress.com tries ... to the online realm. Today, the business has introduced ... a site-wide prom dress promotion. , The new prom ... each and every dress lover. They are specially designed ... 2015 prom dresses should visit its website before ...
(Date:12/25/2014)... 2014 Residents at Abernethy ... showed their generous spirit by providing holiday gifts ... Parenting Network- Grandparents Raising Grandchildren program. , Following ... the largest Christmas tree on the campus of ... residents of the Abernethy Village Association (AVA). Each ...
Breaking Medicine News(10 mins):Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 4Health News:Don't Let Burns Mar Your Holidays 2Health News:Angelweddingdress 2015 Prom Dresses Online Now 2Health News:Retirement Community Residents Make Impact During Holiday Season 2
... MAY 28 Family Health International announced today that ... from the Bill & Melinda Gates Foundation. The ... led by David C. Sokal, M.D., studying a novel ... Sokal,s project is one of 81 grants announced by ...
... Identify Developmental Delays and Promote GrowthNEW ORLEANS, May 28 ... - 11:30am , at 1315 Jefferson Highway , ... "Reach Out and Read " with Louisiana,s First Lady ... program. In this initiative, pediatricians encourage parents to read ...
... with a terminal illness, African-American seniors were two times ... life-prolonging treatments, according to a University of Pittsburgh study ... the Journal of General Internal Medicine . ... M.P.H., associate professor of medical, clinical and translational science ...
... owned subsidiary of sanofi-aventis U.S. LLC, has agreed to pay ... violated the False Claims Act by misreporting drug prices in ... Department announced today. ... that between 1995 and 2000, Aventis and its corporate predecessors ...
... Public/Private Partnership Launches at State Legislative Hearing TRENTON, N.J., ... that could cause grave harm to patient care in ... New Jersey Chamber of Commerce Foundation today announced a ... will have the nursing workforce it needs to meet ...
... Kyowa Hakko U.S.A., Inc. (Kyowa Hakko USA), the wholly ... has announced it has completed GRAS (Generally Recognized As ... Citicoline. Cognizin(R) is a branded form of Citicoline, a ... Citicoline provides an essential nutrient for cells -- ...
Cached Medicine News:Health News:Family Health International Receives $100,000 Grand Challenges Explorations Grant for Innovative Global Health Research Project Led by David Sokal, M.D. 2Health News:Family Health International Receives $100,000 Grand Challenges Explorations Grant for Innovative Global Health Research Project Led by David Sokal, M.D. 3Health News:Family Health International Receives $100,000 Grand Challenges Explorations Grant for Innovative Global Health Research Project Led by David Sokal, M.D. 4Health News:Ochsner Introduces Literacy Program to Promote Healthy Minds 2Health News:Blacks more likely to opt for life-sustaining measures at end of life 2Health News:Aventis Pharmaceutical to Pay U.S. $95.5 Million to Settle False Claims Act Allegations 2Health News:$22 Million Initiative Aims to Reverse New Jersey's Nurse Faculty Shortage, Avert Health Care Crisis 2Health News:$22 Million Initiative Aims to Reverse New Jersey's Nurse Faculty Shortage, Avert Health Care Crisis 3Health News:$22 Million Initiative Aims to Reverse New Jersey's Nurse Faculty Shortage, Avert Health Care Crisis 4Health News:$22 Million Initiative Aims to Reverse New Jersey's Nurse Faculty Shortage, Avert Health Care Crisis 5Health News:Kyowa Hakko USA Announces GRAS Self-Affirmation for Novel Brain Health Ingredient Cognizin(R) Citicoline 2
(Date:12/24/2014)... December 24, 2014 ... Global Disposable Syringe Industry of 178 pages ... business intelligence library. The 2014 ... Industry is a professional and deep research ... overview analysis, the report introduces Disposable Syringe ...
(Date:12/24/2014)... MASON, Ohio , Dec. 23, 2014 /PRNewswire/ ... industry-leading treatment decision support to healthcare providers for ... that it has secured $30 million in equity ... Virginia C. Drosos , President and Chief ... increased clinical adoption and development of Assurex Health,s ...
(Date:12/24/2014)... , Dec. 23, 2014  The American ... blood pressure target for people with diabetes and ... or high doses of statins, in keeping with ... enacted by the American College of Cardiology (ACC) ... reflected in the most recent changes to the ...
Breaking Medicine Technology:World Disposable Syringe Market 2014 Report: China and Regional Analysis 2World Disposable Syringe Market 2014 Report: China and Regional Analysis 3World Disposable Syringe Market 2014 Report: China and Regional Analysis 4World Disposable Syringe Market 2014 Report: China and Regional Analysis 5Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 2Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 3Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 4New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 2New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 3New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 4
The Sabre 2400 provides high power performance and key user features to meet today's demanding electrosurgical needs. It is an ideal general-purpose electrosurgical generator....
The ExcaliburPlus PC is the most powerful isolated ESU with 10,000 V PTP in spray coag....
The CE marked HF coagulator which meets the highest ISO safety features....
Finesse electrosurgical generator (100-120 VAC) utilizes a patented design that integrates the electrosurgical generator and smoke evacuation system into a single compact unit....
Medicine Products: