Navigation Links
Redox-active iron is a sensor of cognitive impairment associated with Alzheimer's disease
Date:4/4/2008

April 4, 2008 -- An innovative discovery has been reported that highlights the problems that oxidative stress resulting from iron cumulated in the human brain can generate in relation with the pathogenesis of Alzheimer's disease (AD), the brain disorder affecting almost 30 million throughout the world. The results of research carried out by Drs. Manuel Lavados, Patricio Fuentes and Leonel Rojo from the laboratory of Professor Dr. R.B. Maccioni of the School of Medicine of the University of Chile, and the International Center for Biomedicine, together with his colleagues, appeared recently in Volume 13, Issue 2 of the prestigious Journal of Alzheimer's Disease (JAD). For several decades this laboratory has been acknowledged as one of the main world contributors to our understanding of AD and the development of tools for its early diagnosis.

The study focuses on the reactivity of iron in the cerebrospinal fluid (CSF) and its correlation with the severity of cognitive decline in both patients with AD and subjects diagnosed with mild cognitive impairment (MCI). Different stages of cognitive and functional impairment are associated with changes in CSF reactive iron. CSF samples from 56 seniors classified into 4 groups according to their scores on the Clinical Dementia Rating scale (CDR) were compared in respect to the levels of a particular form of iron, the redox-active iron.

Interestingly, redox-active iron levels in the CSF increased with the degree of cognitive impairment from normal to MCI subjects, while AD patients showed an abrupt decrease to levels close to zero. However, no difference in the total CSF iron was found between the different groups. Given the relevance of oxidative damage in neurodegeneration occuring during the course of dementia, the development of cognitive and functional decline appears to be associated with the presence of redox-active iron in the CSF. The abrupt decrease in redox-active iron found in patients affected with AD may represent a terminal situation, whereby the central nervous system attempts to minimize iron-associated toxicity.

A possible mechanism to explain the decrease of redox-active CSF iron during the course of the disease could be the sequestration of this metal by the aggregation of a brain component called amyloid peptides (A) into the senile plaques, anomalous structures where cumulative iron has been found. High redox-active CSF iron levels could increase the production of the amyloid- protein precursor (APP) in the neuronal membrane, while the soluble form of APP (A peptide) could act as an iron chelator promoting A peptides aggregation into the senile plaques. The suggested mechanism could represent a homeostatic process by the brain that fights to reduce the cascade of cellular insults in AD, in order to regulate the CSF iron levels and its toxicity. These findings indicate that the decrease in redox-active CSF iron may correspond to a final late effort by brain cells to decrease oxidative stress mediated by iron.

This discovery offers the possibility to monitor iron levels in the CSF in relation with cognitive impairment and perhaps be used as part of a battery of biomarkers for an early diagnosis of these disorders, thus facilitating the appropriate treatment to patients and increasing their quality of life.


'/>"/>

Contact: Astrid Engelen
a.engelen@iospress.nl
31-206-883-355
IOS Press
Source:Eurekalert

Related medicine news :

1. Discovery of sugar sensor in intestine could benefit diabetes
2. Biosensors to probe the metals menace
3. Leading-edge body sensor could help produce sporting champions
4. Tiny Sensor Could Spot Cancer Early
5. Area deep within the brain found to play role in sensory perception
6. Study Offers Insights Into Sensory Perceptions
7. GainSpan Unveils Wi-Fi(R) Sensor Network Solution With Years of Battery Life
8. Biometric sensors no dirtier than doorknobs, study finds
9. Scientists Spot Eyes Motion Sensors
10. Space sensors shed new light on air quality
11. Investigating causes of asthma attacks: New sensor system monitors environmental exposure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... that was developed to enhance the health of felines. The formula is all-natural and ... main herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are ...
(Date:6/25/2016)... ... , ... Austin residents seeking Mohs surgery services, can now turn to Dr. ... Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization to include ... in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction of Glenn ...
(Date:6/25/2016)... CA (PRWEB) , ... June 25, 2016 , ... As ... with Magna Cum Laude and his M.D from the David Geffen School of Medicine ... and returned to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June 14 ... The article goes on to state that individuals are now more comfortable seeking to ... operations such as calf and cheek reduction. The Los Angeles area medical group, Beverly ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association (PHA) ... will receive two significant new grants to support its work to advance research ... anniversary by recognizing patients, medical professionals and scientists for their work in fighting ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016  Collagen Matrix, ... design, development and manufacturing of collagen and mineral ... announced today that Bill Messer has ... Marketing to further leverage the growing portfolio of ... devices. Bill joins the Collagen Matrix ...
(Date:6/24/2016)... -- The Academy of Managed Care Pharmacy (AMCP) today ... allow biopharmaceutical companies to more easily share health care ... coverage decisions, a move that addresses the growing need ... The recommendations address restrictions in the sharing of product ... a prohibition that hinders decision makers from accessing HCEI ...
(Date:6/24/2016)... 2016   Pulmatrix, Inc ., (NASDAQ: ... drugs, announced today that it was added to the ... its comprehensive set of U.S. and global equity indexes ... important milestone for Pulmatrix," said Chief Executive Officer ... our progress in developing drugs for crucial unmet medical ...
Breaking Medicine Technology: