Navigation Links
Redesigned protein accelerates blood clotting
Date:12/22/2008

and heart attacks in otherwise healthy people. In patients with hemophilia, however, enhanced clotting is desirable. On the other hand, we have sought to change the protein's structure as little as possible, because the immune system is more likely to react the more we change it."

More Effective Without Drawing Notice

Blood clotting involves more than a dozen proteins known to take part in a cascade of chemical reactions inside blood vessels following injury, with each factor, or complex of factors, activating the next in the chain. Named for roman numerals, these clotting factors include factor VIII, which is modified slightly to form an active cofactor, VIIIa, and partners with factor IX to activate factor X. Factor X creates a burst of thrombin, which in turn generates fibrin, the sticky protein strands that form a web-like clot over damaged tissue.

As Fay's team gained a deeper understanding of Factor VIII's structure over 20 years, it gradually became clear how they could change it to make the protein more likely to drive clotting. In 2005, he and Wakabayashi published work showing that swapping out a naturally occurring glutamic acid with an alanine at a specific spot in the calcium binding site on factor VIII doubled its ability to bind with factor IX and increased clotting. Factor VIII has on its surface pocket-like chains of amino acids shaped to hold calcium, a metallic element that makes factor VIII better able to bind to factor IX.

While the past work increased the protein's activity (binding with factor IX), the current work dramatically increased the stability of factor VIII. In this context, stability is the ability of the protein to withstand the rigors of manufacturing and of exposure to the human blood stream. It must resist forces that would unravel it, or tear it apart, before it can have its therapeutic effect. Standard stability tests include exposing a protein to increased temperature (thermal
'/>"/>

Contact: Greg Williams
Greg_Williams@urmc.rochester.edu
585-275-3676
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Solving California Nursing Shortage Requires Redesigned Education System
2. Redesigned Blue Shield of California Website Makes Finding a Doctor Online Easier and Faster
3. 2 Cardiovascular Proteins Tied to Severity of Alzheimers
4. Two cardiovascular proteins pose a double whammy in Alzheimers
5. Manipulating Key Protein May Prevent Eczema
6. Stopping ovarian cancer by blocking proteins coded by notorious gene
7. Tau protein expression predicts breast cancer survival -- though not as expected
8. Einstein researchers discover protein that contributes to cancer spread
9. Scientists ID Protein Aiding Breast Cancer Spread
10. Mutant proteins result in infectious prion disease in mice
11. CSHL scientists show how a protein that determines cell polarity prevents breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/1/2015)... It’s raining bills on Capitol Hill with members in ... support for telemedicine. , “Such action is unprecedented ... Congress,” said Jonathan Linkous, CEO of the American Telemedicine Association ... to embrace the use of telecommunications in the delivery of ... mission to improve quality, access, equity and affordability of healthcare.”, ...
(Date:5/1/2015)... Ernst & Young (EY) has announced ... & CSO, and Burak Sezen, Co-Founder & CTO of ... Entrepreneur Of The Year® 2015 Awards in the Ohio ... a global leader in assurance, tax, transaction and advisory ... the top audit companies in the world. The awards ...
(Date:5/1/2015)... 2015 The Quail Creek Relay for Life ... Since 2001, the Quail Creek Relay team has raised almost ... throughout the year, including their biggest event, January’s Dinner and ... , Quail Creek Relay for Life team was established ... Kerwin, fitness director, states, “I was hooked when I learned ...
(Date:5/1/2015)... May 01, 2015 As the sale ... its 18-month anniversary, many people in the industry are ... , According the latest annual report by the ... percent in 2014, and reached nearly $3 billion in ... love affair with cannabis, combined with the ongoing economic ...
(Date:5/1/2015)... RICHMOND, VA (PRWEB) May 01, 2015 ... announce partnerships with the Hickory Crawdads (NC) and the ... sweetFrog will have in-stadium concession locations and offer fans ... a part of the Hickory Community,” said Luke Shook, ... is a great opportunity and we look forward to ...
Breaking Medicine News(10 mins):Health News:ATA: Congress Floods the Halls with Telemedicine Proposals 2Health News:RowdMap, Inc. Named as a Ernst & Young Entrepreneur Of The Year® 2015 Award Finalist 2Health News:Quail Creek Country Club’s Relay for Life Team Raised Over $89,000 for American Cancer Society 2Health News:Colorado cannabis dispensary owner credits employees for successful “420” retail sales figures 2Health News:Colorado cannabis dispensary owner credits employees for successful “420” retail sales figures 3Health News:sweetFrog Announces Minor League Baseball Partnerships 2
... help surgeons limit nerve damage while performing a robotic ... according to a study performed at the University of ... used to evaluate 38 neurovascular bundles in 19 men ... the neurovascular resection plan in 20/38 neurovascular bundles," said ...
... which is a highly effective colorectal screening test, is feasible ... to a study performed at the University of Arizona in ... performed on 86 patients at two remote medical centers (343 ... performed CTC on the patients and the data obtained was ...
... saves a life. Saturday, April 25 is World Malaria Day. , ... ... teaming up with the United Nations Foundation and its Nothing But Nets ... his New Look Foundation, Raymond and the UN Foundation will provide opportunities ...
... 2009 -- In "Only 10 Seconds to Care: Help and ... the book publishing program of the American College of Physicians ... about the healing power of compassionate words and actions that ... a world of difference to patients. , "Because of demands ...
... Beyond Basic NutritionNEW ORLEANS, April 23 Data ... New Orleans suggest raisin and dried fruit consumption ... obesity. The analysis examined the association between dried ... in adults 19 years old and older, using ...
... today an exclusive distribution agreement with ELITech UK Limited ... Kingdom. The distribution agreement marks the beginning of ... expands its reach both in scope and geography. ... in surgery suites and catheterization labs within UK hospitals ...
Cached Medicine News:Health News:'Only 10 Seconds to Care' by Dr. Wendy S. Harpham helps heal clinician-patient bonds 2Health News:Raisin and Dried Fruit Consumption Associated With Reduced Abdominal Obesity 2Health News:Accumetrics, Inc. Announces United Kingdom Distribution Agreement With ELITech UK Limited 2
(Date:4/30/2015)... April 30, 2015 Abaxis, Inc. (NasdaqGS: ... analysis systems, today reported financial results for the fourth ... Fourth quarter and fiscal 2015 overview: , ... fourth quarter, up 33% over last year,s comparable quarter, ... , Diluted EPS of $0.50 for the fourth ...
(Date:4/30/2015)... 2015  Accuray Incorporated (Nasdaq: ARAY ) ... with MIM Software Inc. to further develop adaptive ... ® product portfolios. The new software solution ... is Accuray,s second collaboration with MIM; the previous ... iPad-based treatment plan review capability, PlanTouch™. ...
(Date:4/30/2015)...  Tandem Diabetes Care ® , Inc. (NASDAQ: TNDM ... ® and t:flex™ Insulin Pumps, today reported its financial ... In comparing the first quarter of 2015 to the ... to $12.3 million from $8.1 million , t:slim Pump ... "Our investment in resources to build the foundation ...
Breaking Medicine Technology:Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 2Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 3Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 4Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 5Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 6Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 7Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 8Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 9Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 10Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 11Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 12Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 13Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 14Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 15Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 16Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 17Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 18Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 19Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 20Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 21Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 22Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 23Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 24Accuray Signs Agreement with MIM Software Inc. to Develop Adaptive Therapy Software 2Accuray Signs Agreement with MIM Software Inc. to Develop Adaptive Therapy Software 3Tandem Diabetes Care Reports First Quarter 2015 Financial Results 2Tandem Diabetes Care Reports First Quarter 2015 Financial Results 3Tandem Diabetes Care Reports First Quarter 2015 Financial Results 4Tandem Diabetes Care Reports First Quarter 2015 Financial Results 5Tandem Diabetes Care Reports First Quarter 2015 Financial Results 6
... Fortis Healthcare, India,s leading provider of ... and Masimo (NASDAQ: MASI ) ... allows Fortis hospitals access to Masimo,s full line of ... continuous patient monitoring solutions. As part ...
...  PAREXEL International Corporation (NASDAQ: PRXL ) will release ... on Monday, April 30, 2012 after the close of the ... at www.PAREXEL.com and on the PR Newswire website ... conference call and live webcast at 10:00 a.m. ET on ...
Cached Medicine Technology:Fortis Healthcare Signs Agreement Giving India's Fastest-Growing Hospital Chain Access to Masimo's State-of-the-Art Noninvasive Patient Monitoring Solutions 2Fortis Healthcare Signs Agreement Giving India's Fastest-Growing Hospital Chain Access to Masimo's State-of-the-Art Noninvasive Patient Monitoring Solutions 3Fortis Healthcare Signs Agreement Giving India's Fastest-Growing Hospital Chain Access to Masimo's State-of-the-Art Noninvasive Patient Monitoring Solutions 4Fortis Healthcare Signs Agreement Giving India's Fastest-Growing Hospital Chain Access to Masimo's State-of-the-Art Noninvasive Patient Monitoring Solutions 5Fortis Healthcare Signs Agreement Giving India's Fastest-Growing Hospital Chain Access to Masimo's State-of-the-Art Noninvasive Patient Monitoring Solutions 6Fortis Healthcare Signs Agreement Giving India's Fastest-Growing Hospital Chain Access to Masimo's State-of-the-Art Noninvasive Patient Monitoring Solutions 7Fortis Healthcare Signs Agreement Giving India's Fastest-Growing Hospital Chain Access to Masimo's State-of-the-Art Noninvasive Patient Monitoring Solutions 8PAREXEL Announces Date of Third Quarter Fiscal Year 2012 Earnings Release and Conference Call 2
The moist air humidifying chamber is designed for the infusion of humidified air during phakic fluid air exchange. Sterile single-use. 10 per box. Most popular size or model....
Used with eye shield to cushion the eye. Eliminates need for taping shield. No sticky residue. Package 50 per box. Assorted colors....
Child size. Clear plastic. Accommodates either eye. Packaged 12 per box. Available in either adult or pediatric size....
... 45 cc/minute. Pore size: ... fluids at flow rate ... membrane support rated at ... via prefilled syringe and ...
Medicine Products: