Navigation Links
Redesigned protein accelerates blood clotting
Date:12/22/2008

and heart attacks in otherwise healthy people. In patients with hemophilia, however, enhanced clotting is desirable. On the other hand, we have sought to change the protein's structure as little as possible, because the immune system is more likely to react the more we change it."

More Effective Without Drawing Notice

Blood clotting involves more than a dozen proteins known to take part in a cascade of chemical reactions inside blood vessels following injury, with each factor, or complex of factors, activating the next in the chain. Named for roman numerals, these clotting factors include factor VIII, which is modified slightly to form an active cofactor, VIIIa, and partners with factor IX to activate factor X. Factor X creates a burst of thrombin, which in turn generates fibrin, the sticky protein strands that form a web-like clot over damaged tissue.

As Fay's team gained a deeper understanding of Factor VIII's structure over 20 years, it gradually became clear how they could change it to make the protein more likely to drive clotting. In 2005, he and Wakabayashi published work showing that swapping out a naturally occurring glutamic acid with an alanine at a specific spot in the calcium binding site on factor VIII doubled its ability to bind with factor IX and increased clotting. Factor VIII has on its surface pocket-like chains of amino acids shaped to hold calcium, a metallic element that makes factor VIII better able to bind to factor IX.

While the past work increased the protein's activity (binding with factor IX), the current work dramatically increased the stability of factor VIII. In this context, stability is the ability of the protein to withstand the rigors of manufacturing and of exposure to the human blood stream. It must resist forces that would unravel it, or tear it apart, before it can have its therapeutic effect. Standard stability tests include exposing a protein to increased temperature (thermal
'/>"/>

Contact: Greg Williams
Greg_Williams@urmc.rochester.edu
585-275-3676
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Solving California Nursing Shortage Requires Redesigned Education System
2. Redesigned Blue Shield of California Website Makes Finding a Doctor Online Easier and Faster
3. 2 Cardiovascular Proteins Tied to Severity of Alzheimers
4. Two cardiovascular proteins pose a double whammy in Alzheimers
5. Manipulating Key Protein May Prevent Eczema
6. Stopping ovarian cancer by blocking proteins coded by notorious gene
7. Tau protein expression predicts breast cancer survival -- though not as expected
8. Einstein researchers discover protein that contributes to cancer spread
9. Scientists ID Protein Aiding Breast Cancer Spread
10. Mutant proteins result in infectious prion disease in mice
11. CSHL scientists show how a protein that determines cell polarity prevents breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... HealthDay Reporter TUESDAY, Dec. ... fast approaching, a new study reveals that states that routinely ... drunk drivers on their roads. The finding suggests that ... able to deter inebriated revelers from getting behind the wheel ... being passed regarding drinking and driving," said study lead author ...
(Date:12/15/2014)... Cancer researchers have just published an ... of deadly malignant pleural mesothelioma. Surviving Mesothelioma has just ... Click here to read it now. , ... Center, and New York’s Langone Medical Center performed complete ... in an effort to pinpoint the genes that ...
(Date:12/15/2014)... SIMpalm, a leading mobile app development company , ... client, which allows users to keep track of wines ... the right wine. At the center of WineMatch ... and wine information. All this information is assembled to ... that are close counterparts to one another are called ...
(Date:12/15/2014)... SUNDAY, Dec. 14, 2014 (HealthDay News) -- Expert pilots ... which explains why they make better decisions during landings, ... the most difficult techniques for pilots to master, and ... of fatal crashes occur during final approach and landing. ... pilots and 12 moderately experienced pilots while they were ...
(Date:12/15/2014)... 15, 2014 In support of ... attention to restrictive state laws that may have ... this important area of public health policy. , ... the Integrity of Independent Review, contends that state ... independent peer review determinations can result in subpar ...
Breaking Medicine News(10 mins):Health News:Enforcement of Drunk Driving Laws Makes Roads Safer, Study Finds 2Health News:Enforcement of Drunk Driving Laws Makes Roads Safer, Study Finds 3Health News:New Study Reveals Genetic Mutations That May Trigger Mesothelioma, According to Surviving Mesothelioma 2Health News:Use WinMatch Connect App to Keep Track of Wines You Like 2Health News:Study Shows Why Expert Pilots Are Experts 2Health News:NAIRO Calls for Higher Quality Independent Peer Review By Ending Restrictive State Laws 2
... geared to genetic blueprints from Elite Books, TUCSON, Ariz., ... It,plays a key role in the development of Alzheimer,s Disease ... it is greatly affected,by diet. In her seminal book, ... Heart and Alzheimer,s Using the Body,s Own Genes,(Elite, Hardcover, $27.95, ...
... FRAMINGHAM, Mass., Nov. 5 StatSure Diagnostic,Systems, Inc. ... U.S.,Food and Drug Administration ("FDA"), through its Center ... under the Clinical Laboratory,Improvements Amendments of 1988 ("CLIA") ... patented "barrel" technology. The HIV 1/2 product,is marketed ...
... to place systems in more physician offices could ... of underserved patient populations, NEW YORK, Nov. 5 ... New York (HIP) will convene an educational seminar in,New ... treating,underserved patient populations. The seminar, to be held at ...
... Research Findings to Impact Human Health, Agricultural Science, ... Beauty announced that they successfully sequenced the complete ... fungus,responsible for the onset of dandruff and other ... are published in today,s online edition of,Proceedings of ...
... 5 Millennium,Pharmaceuticals, Inc. (Nasdaq: MLNM ) ... Suisse Healthcare Conference will be webcast live and,may ... the Company,s website, http://www.millennium.com . (Logo: ... an overview of the Company, an update on,clinical ...
... to Compulsory Acquisition, WARSAW, Ind. and MONTREAL, Nov. ... ZMH), a leader in the orthopaedics,industry, and its indirect ... pursuant to the extension of the Offer,made for all ... a leader in computer navigation for orthopaedic,surgery, it has ...
Cached Medicine News:Health News:Groundbreaking Apo E Gene Diet Linked to Alzheimer's Disease and Heart Disease Prevention 2Health News:StatSure's Patented HIV 'Barrel' Technology Receives CLIA Waiver From FDA 2Health News:StatSure's Patented HIV 'Barrel' Technology Receives CLIA Waiver From FDA 3Health News:GHI and HIP Lead Effort to Expand Electronic Health Record System Throughout the City of New York 2Health News:Photo: Scientists Complete Genome Sequence of Fungus Responsible for Dandruff, Skin Disorders 2Health News:Photo: Scientists Complete Genome Sequence of Fungus Responsible for Dandruff, Skin Disorders 3Health News:2007 Credit Suisse Healthcare Conference to Webcast Millennium Presentation 2Health News:Zimmer Announces Successful Completion of ORTHOsoft Takeover Bid 2Health News:Zimmer Announces Successful Completion of ORTHOsoft Takeover Bid 3
(Date:12/17/2014)... YORK , Dec. 17, 2014 ... imaging (MRI), the MRI market is seeing new ... and breast MRI scans account for the majority ... a higher resolution of images, which are creating opportunities ... imaging (MRI) market is growing at a rate ...
(Date:12/17/2014)... -- , The new Dompé ... information concerning the biopharmaceutical Group,s national and international clinical research ... the recently launched institutional website that is receiving accolades from ... a new chapter in the fascinating story of Drug Discovery ... panoramic hub on the world of clinical research, ranging from ...
(Date:12/17/2014)... BUENA, N.J. , Dec. 17, 2014  IGI ... announced today the closing of its offering of $125 ... due 2019 (the "Notes").  The Notes were offered and ... 144A under the Securities Act of 1933, as amended ... at a fixed rate of 3.75% per year, payable ...
Breaking Medicine Technology:Kalorama: 3T Advancements Bringing New Growth to the MRI Market 2Kalorama: 3T Advancements Bringing New Growth to the MRI Market 3Dompé Offers a New "Window" on the World of Scientific Research, with the http://www.dompetrials.com Website, Dedicated to Clinical Trials 2Dompé Offers a New "Window" on the World of Scientific Research, with the http://www.dompetrials.com Website, Dedicated to Clinical Trials 3IGI Laboratories Announces Closing of $125 Million of 3.75% Convertible Senior Notes Due 2019 2IGI Laboratories Announces Closing of $125 Million of 3.75% Convertible Senior Notes Due 2019 3IGI Laboratories Announces Closing of $125 Million of 3.75% Convertible Senior Notes Due 2019 4
... , Rochester Medical Corporation (Nasdaq: ROCM ) will ... 2009. The Company will then hold a quarterly conference call ... 3:30 p.m. central time (4:30 p.m. eastern time). , This call ... Medical,s website at www.rocm.com . To listen ...
... Oct. 28 Qualsec (OTC Bulletin Board: QLSZ), which recently ... has been elected as a member of the Board of ... of clinical experience followed by 6 years of medical device ... and only FDA cleared RFID medical information device of its ...
Cached Medicine Technology:Rochester Medical Announces Fourth Quarter 2009 Earnings Conference Call Thursday, November 5th 2009 2VitaminSpice Appoints Dr. Richard F. Seelig as Director 2
3 mm diameter roller blade, 15 mm from angle to tip. Round handle....
2 mm wide x 3 mm long, with rounded triangular tip. Angled 45 degrees. Hexagonal handle....
Duckbill type sharp. 3 mm wide x 8 mm long curved blade. Octagonal handle....
9 mm slightly curved blade. Hexagonal handle....
Medicine Products: