Navigation Links
Red wine, fruit compound could help block fat cell formation
Date:4/4/2012

WEST LAFAYETTE, Ind. - A compound found in red wine, grapes and other fruits, and similar in structure to resveratrol, is able to block cellular processes that allow fat cells to develop, opening a door to a potential method to control obesity, according to a Purdue University study.

Kee-Hong Kim, an assistant professor of food science, and Jung Yeon Kwon, a graduate student in Kim's laboratory, reported in this week's issue of the Journal of Biological Chemistry that the compound piceatannol blocks an immature fat cell's ability to develop and grow.

While similar in structure to resveratrol ╨ the compound found in red wine, grapes and peanuts that is thought to combat cancer, heart disease and neurodegenerative diseases ╨ piceatannol might be an important weapon against obesity. Resveratrol is converted to piceatannol in humans after consumption.

"Piceatannol actually alters the timing of gene expressions, gene functions and insulin action during adipogenesis, the process in which early stage fat cells become mature fat cells," Kim said. "In the presence of piceatannol, you can see delay or complete inhibition of adipogenesis."

Over a period of 10 days or more, immature fat cells, called preadipocytes, go through several stages to become mature fat cells, or adipocytes.

"These precursor cells, even though they have not accumulated lipids, have the potential to become fat cells," Kim said. "We consider that adipogenesis is an important molecular target to delay or prevent fat cell accumulation and, hopefully, body fat mass gain."

Kim found that piceatannol binds to insulin receptors of immature fat cells in the first stage of adipogenesis, blocking insulin's ability to control cell cycles and activate genes that carry out further stages of fat cell formation. Piceatannol essentially blocks the pathways necessary for immature fat cells to mature and grow.

Piceatannol is one of several compounds being studied in Kim's laboratory for its health benefits, and it is also present in different amounts in red grape seeds and skin, blueberries, passion fruit, and other fruits.

Kim would like to confirm his current finding, which is based on a cell culture system, using an animal model of obesity. His future work would also include determining methods for protecting piceatannol from degrading so that concentrations large enough would be available in the bloodstream to stop adipogenesis or body fat gain.

"We need to work on improving the stability and solubility of piceatannol to create a biological effect," Kim said.


'/>"/>

Contact: Brian Wallheimer
bwallhei@purdue.edu
765-496-2050
Purdue University
Source:Eurekalert  

Related medicine news :

1. Many Americans Ill-Informed About Red Wine, Sea Salt: Survey
2. Moderate drinking, especially wine, associated with better cognitive function
3. New Flu Discovered in Guatemalan Fruit Bats
4. Citrus Fruits May Lower Womens Stroke Risk
5. Veggies, Fruit May Lower Womens Stroke Risk
6. U.S. Teens Dont Eat Enough Fruits and Veggies: CDC
7. Not Everyone Shuns Fruits and Veggies
8. Got High Blood Pressure? Kiwi Fruit May Help
9. MyPlate: Make half your plate fruits and vegetables
10. Nuclear receptors battle it out during metamorphosis in new fruit fly model
11. College Students Missing Out on Fruits, Veggies: Survey
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Red wine, fruit compound could help block fat cell formation
(Date:8/31/2020)... ... , ... Cardiothoracic surgeons at Allegheny General Hospital (AGH), part ... (CMU) to develop a new heart monitoring device designed to serve as an ... AGH/CMU team was recently awarded a “Trailblazer” grant from the National Institutes of ...
(Date:8/31/2020)... ... 2020 , ... Just found out your dear friend has cancer? , It’s hard to hear ... member shares their diagnosis. Once the shock wears off, the questions and fears can be ... the best ways to help? Words are failing me. I’m scared. I want to DO ...
(Date:8/31/2020)... ... August 31, 2020 , ... Want to get moving, break up your ... Foundation (CPARF) is thrilled to launch its fourth annual STEPtember campaign in the United ... STEPtember meets everyone wherever they are at this moment — encouraging people to move ...
(Date:8/31/2020)... ... 31, 2020 , ... Colorado State University Global (CSU Global) ... online education – is proud to announce its new master’s degree in ... kind in the nation, the 60-credit hour program is designed to provide students ...
(Date:8/31/2020)... ... ... topsy-turvy economic outlook continues to put financial strain on many of us, so it just ... our monthly expenses and put more into savings, if possible. , “That’s a great way ... net in place in case something were to happen to you,” says Lee Duncan, CMO ...
Breaking Medicine News(10 mins):
(Date:9/2/2020)... (PRWEB) , ... September 02, 2020 , ... U.S. ... Jonathan Lee . Dr. Lee will work at Bethesda Dermatopathology Lab. ... his B.A. from the University of California, Berkley. He went on to receive his ...
(Date:9/1/2020)... ... September 01, 2020 , ... Neil Oberfeld of ... Secretary to the Board of Trustees and committee chair of the Governance Committee ... a Denver-based nonprofit organization that fights for the education, health, and financial stability ...
(Date:9/1/2020)... ... 01, 2020 , ... September is National Ovarian Cancer Awareness Month. Ovarian ... other cancer of the female reproductive system. The American Cancer Society estimates that ... women will die from this disease. Throughout the month of September, Women’s Excellence ...
Breaking Medicine Technology: