Navigation Links
Red-Grape Compound May Improve Diabetes
Date:10/22/2009

But so far resveratrol works only as an injection into the brain of mice, study finds

THURSDAY, Oct. 22 (HealthDay News) -- New research provides further insight into how a health-boosting compound found in red grapes may help the body fend off type 2 diabetes.

But scientists have only seen the effect in mice who received injections in the brain, and no evidence has emerged that consuming red wine or other products made with grapes will alleviate the blood sugar disease.

The findings do tell scientists about how the compound known as resveratrol works on the brain, said senior study author Roberto Coppari.

If scientists know that the brain is a "major player," then drug companies working on related research "will focus on a drug that will penetrate the brain," said Coppari, an assistant professor of internal medicine at University of Texas Southwestern Medical Center in Dallas.

Scientists have been excited about resveratrol, which is found in red grapes, red wine, pomegranates and some other foods, appears to extend the life spans of mice, even those fed a high-fat diet. Resveratrol appears to mimic the effects of severely restricting food intake, which helps a wide variety of animals live longer, Coppari said.

"You can take the spider, fish, and almost every animal in the planet, and give 70 percent of what the animal would normally eat, and you'll see beneficial effects," he said. "Of course, calorie restriction is very difficult to impose on people. You will feel hungry all the time."

In the new study, Coppari and colleagues looked at the effects of resveratrol on diabetes, not life span. Previous research has suggested that the compound helps the body fight off diabetes.

The researchers injected either resveratrol or a placebo into the brains of diet-induced and diabetic mice and watched to see what happened.

Over five weeks, insulin levels returned to half of normal levels in the mice that got the resveratrol injections, even though they were on high-fat diets. Researchers suspect resveratrol activated proteins in the brain called sirtuins.

The insulin levels in the other mice went up, apparently because of their diets.

So why not drink red wine to get the same effects? It won't work, Coppari said, since the amount of resveratrol in red wine is too low. Then there's the matter of the barrier between the bloodstream and the brain, which keeps things out of the brain.

"Clearly, administration of drugs to patients directly into the brain for chronic diseases is not feasible or realistic," said Lindsay Brown, of the University of Queensland's department of physiology and pharmacology in Australia.

"But this study may lead to the development of compounds that are more effective in crossing from the blood to the brain than is resveratrol," said Brown.

The study, which was supported by the American Heart Association, National Institutes of Health and American Diabetes Association, was published online in advance of its print publication in the December issue of the journal Endocrinology.

More information

Learn more about resveratrol from Oregon State University.



SOURCES: Roberto Coppari, Ph.D., assistant professor, internal medicine, University of Texas Southwestern Medical Center, Dallas; Lindsay Brown, Ph.D., University of Queensland's department of physiology and pharmacology, Australia; December 2009 Endocrinology


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. New Compound Shrinks Skin Cancers
2. CriticalPoint(TM) Launches Seven New Virtual Compounder(TM) Training Modules
3. NovaBay Pharmaceuticals to Present New Pre-Clinical Data on Lead Anti-Infective Compound for use in Onychomycosis at the 2009 IDSA Annual Meeting
4. Study shows how to boost value of Alzheimers-fighting compounds
5. Compound Targets, Destroys Cancer Stem Cells in Mice
6. First compound that specifically kills cancer stem cells found
7. New class of compounds discovered for potential Alzheimers disease drug
8. DSM Announces SafeBridge(R) Potent Compound Safety Certification
9. New Compounding Pharmacy Videos Provide Product Information, Teach Safety
10. Novel light-sensitive compounds show promise for cancer therapy
11. Neuromed Announces that Merck & Co., Inc. Terminates Research Collaboration and License Agreement for Compounds Targeting N-Type Calcium Channels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... Canada (PRWEB) , ... June 25, 2016 , ... Conventional ... pursuit of success. In terms of the latter, setting the bar too high can ... risk more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... ... ... was in a crisis. Her son James, eight, was out of control. Prone to extreme ... “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was ... other children and say he was going to kill them. If we were driving ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Comfort Keepers® ... American Cancer Society and the Road To Recovery® program to drive cancer patients to ... and other adults to ensure the highest quality of life and ongoing independence. ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... to recognize Dr. Barry M. Weintraub as a prominent plastic surgeon and the ... in the world, and the most handsome men, look naturally attractive. Plastic surgery ...
(Date:6/24/2016)... Washington, D.C. (PRWEB) , ... June 24, 2016 , ... ... Pro-Am Heroes Golf Classic Tournament held on June 20th at the Woodmont Country ... local charity, Luke’s Wings, an organization dedicated to helping service members that have been ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 23, 2016 Bracket , a leading clinical ... generation clinical outcomes platform, Bracket eCOA (SM) 6.0, at ... 26 – 30, 2016 in Philadelphia , ... Outcome Assessment product of its kind to fully integrate with ... Bracket eCOA 6.0 is a flexible platform for electronic clinical ...
(Date:6/23/2016)... and INDIANAPOLIS , June ... receiving a Lilly Diabetes Tomorrow,s Leaders Scholarship is any ... scholarship winners, announced today online at www.diabetesscholars.org ... type 1 diabetes stand in the way of academic ... supported the Foundation,s scholarship program since 2012, and continues ...
(Date:6/23/2016)... LONDON , June 23, 2016 ... environments  Oticon , industry leaders in ... the launch of Oticon Opn ™, the world,s ... world of possibilities for IoT devices.      ... Opn, Oticon introduces a number of ,world firsts,: ...
Breaking Medicine Technology: