Navigation Links
Recurrent low-grade carcinoma of the ovary less responsive to chemo than more common ovarian cancers
Date:3/10/2008

Tampa, Fla.- Recurrent low-grade serous carcinoma, a rare type of ovarian cancer, is less sensitive to chemotherapy and therefore more difficult to treat than more common high-grade ovarian cancers, according to researchers from The University of Texas M. D. Anderson Cancer Center. The findings were reported at the Society of Gynecologic Oncologists 39th Annual Meeting on Women's Cancers.

The retrospective study is the first to analyze how women with low-grade tumors respond to chemotherapy in recurrent setting and confirms clinical impressions that the tumors are chemoresistant, said lead author David M. Gershenson, M.D., professor and chair of the Department of Gynecologic Oncology at M. D. Anderson. Previous studies have shown similar tumor resistance in newly diagnosed patients, and there is currently no standard of care for women facing the disease.

The results support a growing body of research that shows low-grade ovarian tumors behave differently than their high-grade counterparts, genetically and clinically. "In order to make meaningful advances in treatment, women with low-grade ovarian tumors must not be grouped together with those with more common ovarian tumors. They require unique consideration and more targeted treatment options for a better chance of survival," Gershenson said.

Gershenson and his colleagues identified all patients treated for recurrent low-grade serous carcinoma of the ovary seen at M. D. Anderson from 1990 through 2007 using databases from the Department of Gynecologic Oncology. Out of 52 patients with sufficient clinical information with which to assess response to one or more of 98 different chemotherapy regimens, the overall response rate was only 4 percent. Specifically, researchers found:

  • Among 24 patients who received carboplatin for platinum-sensitive disease, there were two partial responses and one complete response.
  • Of 11 patients who received a taxane/platinum c
    '/>"/>

Contact: Robyn Stein
robyn.stein@gabbe.com
212-220-4444
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Experimental drug boosts survival in recurrent ovarian cancer
2. Ranexa(R) Significantly Reduces Incidence of CV Death, MI or Recurrent Ischemia in MERLIN TIMI-36 Patients With Elevated BNP
3. Antegrade bowel intussusception can cause recurrent, chronic postoperative intestinal obstruction
4. Early Results of Phase 2 Trial of Perifosine (KRX-0401) for the Treatment of Recurrent Malignant Gliomas Presented at the 12th Annual Scientific Meeting of Society for Neuro-Oncology
5. U of Minnesota study finds thalidomide shows promise for treatment of recurrent ovarian cancer
6. Altered expression of ultraconserved noncoding RNAs linked to human leukemias and carcinomas
7. A Chinese medicine compound has satisfactory anti-cancer effects on hepatocellular carcinoma
8. Intra-arterial combination chemotherapy induces long-term survival for hepatocellular carcinoma
9. A new chemotherapeutic target for hepatocellular carcinoma
10. Supratek Pharma Inc. announced today that the U.S. Food and Drug Administration (FDA) has cleared its Investigational New Drug (IND) application for SP1049C for the treatment of metastatic adenocarcinoma of the upper gastrointestinal tract
11. How does Fu-Zheng-Jie-Du-Decoction act on PTEN expression in hepatocellular carcinoma?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... Sept. 18, 2014 (HealthDay News) -- Exposure to diverse ... new study. Hearing different languages in the ... willing to learn from people who are different from ... children, like adults, are often biased against interacting with ... said Amanda Woodward, a University of Chicago psychology professor, ...
(Date:9/18/2014)... September 18, 2014 Limited spots remain ... , Only 100 spots are still available for Becker's ... of ASCs on October 23-25, 2014 at the Swissotel ... Review Chief Information Officer Strategy Roundtable on November 4, ... spots remain for Becker's Hospital Review Chief Executive Officer ...
(Date:9/18/2014)... Alan Mozes HealthDay Reporter ... comes to emergency room waiting times, patients seeking care at ... down the clock than those seen at smaller or more ... and our ability to provide timely emergency care varies dramatically ... authors of the new research, Dr. Renee Hsia, an associate ...
(Date:9/18/2014)... (PRWEB) September 19, 2014 ... the Neighborhood Mission (Misión Barrio Adentro), which ... the healthcare system (see Section 6.1.3.). In ... in an Autonomous Service of Pharmaceutical Elaborations ... plant, which provides medicines at a cheaper ...
(Date:9/18/2014)... Baltimore, MD (PRWEB) September 18, 2014 ... Award-winning celebrity and wellness advocate, and Frank Davis, ... Activz Whole-food Nutrition, are pleased to announce ... 150+ ways to make delicious, nutrition-packed meals using ... book is the next step in the ...
Breaking Medicine News(10 mins):Health News:Study: Exposure to Diversity Might Boost Baby's Social Skills 2Health News:Limited Spots Remain at Becker's Upcoming ASC and Hospital Conferences 2Health News:ER Waiting Times Vary Significantly, Studies Find 2Health News:ER Waiting Times Vary Significantly, Studies Find 3Health News:Venezuela Pharmaceutical Market worth $22.2 billion with 12% CAGR by 2020 Says a New Report Available at MarketOptimizer.org 2Health News:Venezuela Pharmaceutical Market worth $22.2 billion with 12% CAGR by 2020 Says a New Report Available at MarketOptimizer.org 3Health News:Venezuela Pharmaceutical Market worth $22.2 billion with 12% CAGR by 2020 Says a New Report Available at MarketOptimizer.org 4Health News:Montel Williams and Frank Davis Announce New Whole-Food Nutrition Recipe Book, The Simple Scoop, at Natural Products Expo East In Baltimore 2Health News:Montel Williams and Frank Davis Announce New Whole-Food Nutrition Recipe Book, The Simple Scoop, at Natural Products Expo East In Baltimore 3
... at the University of Wisconsin-Madison have found that two related ... a team to maintain normal activity in mammary stem cells. ... types. They may also drive the development and growth of ... of Biological Chemistry , the research also suggests that a ...
... SMIP-016 is a promising experimental drug that kills chronic leukemia ... wasn,t known how this kills leukemia cells., This study showed ... explaining how the drug works and how it might be ... has identified a life-and-death signaling role for a molecule on ...
... skin transplant surgery is safe and effective for restoring skin ... first study of its kind in the United States, researchers ... and found that the treated area regained on average 43 ... localized vitiligo, the treated area regained on average ,68 percent ...
... , TUESDAY, May 29 (HealthDay News) -- If you want ... laughing, say researchers who have found that centenarians are often ... perspective. The findings stem from the Longevity Genes Project, ... York City. All the participants in the latest study were ...
... receive about their future fertility following cancer diagnosis, suggests a ... International Journal of Obstetrics and Gynaecology . Infertility can ... numbers of people of reproductive age undergoing such treatment. ... and NHS Grampian - looks at perceptions and use of ...
... HealthDay Reporter , TUESDAY, May 29 (HealthDay News) -- A ... likely to eat better and watch less TV if they ... get reminders from coaches. It,s not clear how much ... it might work, but the study lead author said costs ...
Cached Medicine News:Health News:Breast stem-cell research: Receptor teamwork is required and a new pathway may be involved 2Health News:Breast stem-cell research: Receptor teamwork is required and a new pathway may be involved 3Health News:Researchers identify a 'life-and-death' molecule on chronic leukemia cells 2Health News:Skin transplant offers new hope for vitiligo patients 2Health News:Optimism, Laughter May Bring Long Life 2Health News:Optimism, Laughter May Bring Long Life 3Health News:Men and women receive different fertility advice following cancer diagnosis 2Health News:Men and women receive different fertility advice following cancer diagnosis 3Health News:Cash, Coaching May Boost Healthy Living 2Health News:Cash, Coaching May Boost Healthy Living 3
(Date:9/18/2014)... LONDON , September 18, 2014 ... supply chain community, we,re finally here - the new programme ... in January 2015, part of our global Cool Chain series, ... agenda here ! As the lines between ... have put together a programme that is broad and yet ...
(Date:9/18/2014)... 2014 Relmada Therapeutics, Inc., (OTCQB: RLMD), a ... chronic pain, announced today that it has appointed Mr. ...  Senior Director of Clinical Development. During his ... and led successful global clinical operations teams, in the ... the clinical development of numerous therapeutics and diagnostics across ...
(Date:9/18/2014)... Sept. 18, 2014   Regulus Therapeutics Inc ... company leading the discovery and development of innovative ... its ATHENA natural history of disease study in ... disease with no approved therapy. The ATHENA study ... renal function markers such as Glomerular Filtration Rate ...
Breaking Medicine Technology:Europe's Biggest and Longest-Running Gathering of Life Sciences Logistics, Supply Chain & QA Professionals 2Relmada Therapeutics, Inc. Appoints Christopher W. James As Senior Director of Clinical Development 2Regulus Initiates ATHENA Natural History of Disease Study in Alport Syndrome Patients 2Regulus Initiates ATHENA Natural History of Disease Study in Alport Syndrome Patients 3Regulus Initiates ATHENA Natural History of Disease Study in Alport Syndrome Patients 4Regulus Initiates ATHENA Natural History of Disease Study in Alport Syndrome Patients 5Regulus Initiates ATHENA Natural History of Disease Study in Alport Syndrome Patients 6
... The 5mm AEM Laparoscopic Instruments incorporate ... AEM Instruments are shielded and monitored to ... of the instrument caused by insulation failure ... risk. The protective shield built into all ...
SOLOS Endoscopy shares your commitment to provide every patient with the highest quality care available through our ongoing research and development of advanced surgical instruments and diagnostic so...
... aspiration holes and additional electrode tip ... precise dissection with decreased risk of ... ,Flexible design options allow the ... and multiple tip designs. Optimize specific ...
SOLOS Endoscopy shares your commitment to provide every patient with the highest quality care available through our ongoing research and development of advanced surgical instruments and diagnostic so...
Medicine Products: