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Recurrence risk of autism in younger siblings higher than thought
Date:8/14/2011

ability for developing autism.

Twelve consortium sites located in the United States and Canada participated in the study, with additional sites as far away as Israel engaged in analyses and interpretation of the data. The study included 664 subjects, infants whose average age at enrollment was 8 months, with two-thirds recruited prior to 6 months of age. The researchers followed the participants' development until 36 months, when they were tested for autism.

The study subjects were tested using the Autism Diagnostic Observation Schedule (ADOS), an autism diagnostic tool, and the Mullen Scales of Early Learning, which measures nonverbal cognitive, language and motor skills. Of the 664 participants, a total of 132 infants met the criteria for an autism spectrum disorder. Fifty-four received a diagnosis of autistic disorder and 78 received a diagnosis of Pervasive Developmental Delay Not Otherwise Specified, considered a milder form of autism.

More males than females are affected with autism 80 percent of all affected children are male. The risk to male children held true in the current study. Among the study participants, 26.2 percent of male infants versus 9 percent of female infants were diagnosed with an autism spectrum disorder.

The overall rate of autism spectrum outcomes for all study participants was 18.7 percent. However, there was a significant difference in the recurrence rate based on whether the child had one sibling or more than one sibling with autism. In families with one older child with autism, or simplex families, the rate of incidence was 20.1 percent. Only 37 of the study participants had more than one sibling with autism. But for those families, called multiplex families, the recurrence rate was 32.2 percent.

"It's important to recognize that these are estimates that are averaged across all of the families. So, for some families, the risk will be greater than 18 percent, and for other families it would
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Contact: Phyllis Brown
phyllis.brown@ucdmc.ucdavis.edu
916-734-9023
University of California - Davis Health System
Source:Eurekalert

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