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Recurrence of breast cancer after more than 10 years is an important indicator of survival
Date:3/24/2010

This release is available in Spanish.

Barcelona, Spain: Recurrence of breast cancer in the same area as the original tumour remains the strongest, independent prognostic factor for subsequent metastasis and death, even for patients who have been free of disease for a very long time, according to research presented today (Wednesday) at the seventh European Breast Cancer Conference (EBCC7).

Dr Sven Mieog, MD, a research fellow at Leiden University Medical Centre (Leiden, The Netherlands) will tell the conference that in women treated with breast conserving treatment for early stage breast cancer, a locoregional recurrence remained the most important prognostic factor after a disease-free interval of five years. Moreover, after a disease-free interval of ten years, locoregional recurrence remained the sole independent prognostic factor.

"In patients who were free of disease for more than ten years after primary treatment, locoregional recurrence had a significant impact on both disease-free survival and overall survival," he said. "The increased risk of metastases after a recurrence was approximately four times higher than if there had been no recurrence, and the risk of dying after a recurrence was around eight times higher. However, these levels of increased risk need to be treated with caution because, with the longer time interval between the primary cancer and the recurrence, the number of events goes down, making these calculations less certain, although they remain important for clinicians when deciding on the best treatments."

Dr Mieog and his colleagues pooled data from 7,749 early stage breast cancer patients taking part in four trials run by the European Organisation for Research and Treatment of Cancer (EORTC). The average length of follow-up was 10.9 years and three different analyses looked at: 1) all the patients, 2)
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Contact: Mary Rice
mary@mrcommunication.org
ECCO-the European CanCer Organisation
Source:Eurekalert

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