Navigation Links
Recovery from propofol anesthesia may be sped by use of common stimulant
Date:4/5/2012

The ability of the commonly used stimulant methylphenidate (Ritalin) to speed recovery from general anesthesia appears to apply both to the inhaled gas isoflurane, as previously reported, and to the intravenous drug propofol. Members of the same Massachusetts General Hospital (MGH) research team that reported the isoflurane study are publishing similar results for propofol in the May issue of Anesthesiology, and their paper has been issued online.

"Propofol is the most widely used intravenous general anesthetic, and there is currently no way to reverse its effects," says Ken Solt, MD, of the MGH Department of Anesthesia, Critical Care and Pain Medicine, the paper's corresponding author. "By finding that methylphenidate can reverse general anesthesia with propofol as well as with isoflurane, we show that it may be broadly applicable for waking patients up from different general anesthetic drugs."

The MGH team's previous study in the October 2011 issue of Anesthesiology showed that methylphenidate known to affect arousal pathways in the brain and commonly used to treat attention-deficit hyperactivity disorder significantly decreased the amount of time it took for rats to recover from isoflurane anesthesia. The current study ran very similar experiments in which propofol, which has a different mechanism of action than isoflurane, was the anesthetic agent.

In the first experiments, animals that had lost consciousness after a single dose of propofol were given intravenous methylphenidate or saline, and those receiving methylphenidate recovered almost five minutes faster than those receiving saline. Administration of methylphenidate also induced signs of arousal movement or standing up in rats receiving a constant intravenous dose of propofol, while animals administered saline remained motionless. EEG readings of the brains of animals during constant infusion of a higher propofol dose showed that methylphenidate caused br
'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Recovery Act's One Year Anniversary -- 2009 Was Just the Opening Act
2. Federal Recovery Funds Allow Eries Shriners Hospital to Reduce Energy Costs, Invest Savings in Patient Care
3. U.S. Senate Urgently Needs to Extend Medicaid Match in Economic Recovery Legislation
4. Alliance, Inc. Receives Centers of Excellence in Recovery Grant
5. De-Duplication, Compression and No Double Backups Required: AppAssure Releases the Fastest and Most Scalable Backup & Recovery Solution for Microsoft Hyper-V
6. San Francisco Plastic Surgeon Releases Plastic Surgery Patient Recovery Blog
7. Passages to Recovery Outdoor Addiction Treatment Program Achieves Joint Commission Accreditation
8. Economic Recovery and New Healthcare Legislation: The Stars Are Aligned for Increased Adoption of HR Management Systems (HRMS)
9. New Laser Treatment Offers Revolutionary Response to Aesthetic Procedure Candidates' Number One Concern: Recovery Time
10. Arizona Surgeon Performs Hip Replacement Surgery with Fast Recovery, Less Pain
11. Addiction and Recovery: Life Force Dallas
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... (HealthDay News) -- Expectant parents should leave prenatal picture-taking ... recommends. Use of ultrasound imaging and heartbeat monitors ... risk-free, the agency warns. "Although there is ... ultrasound imaging and heartbeat monitors, prudent use of these ... Vaezy, an FDA biomedical engineer, said in an agency ...
(Date:12/17/2014)... -- Greater participation in music classes may benefit children,s ... kids in the nonprofit Harmony Project, which provides music ... Over two years, children who actively participated in ... processes speech and reading, compared to those with lower ... participation in music classes occurred in the same areas ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. 16, 2014 (HealthDay ... health, but a growing body of evidence shows the ancient ... In fact, the benefits were similar to those of ... Chu, a doctoral candidate at Harvard University,s Health Policy Program ... that people randomly assigned to take yoga classes saw improvements ...
(Date:12/15/2014)... Grants Pass, OR (PRWEB) December 15, 2014 ... factors perceived by United States women as impacting skin ... – the “Four C’s of skin care.” Water and ... the conclusions in a recent article describing the survey ... her experience, every item in every category discussed would ...
(Date:12/15/2014)... Veretekk.com, Inc. announced today a strategic ... JM Ocean Avenue has secured exclusive benefit to the ... system. JM Ocean Avenue is a direct sales ... Avenue and JM International, with partial ownership coming from ... company. , “After nearly 2 decades of servicing the ...
Breaking Medicine News(10 mins):Health News:FDA Warns Against Fetal 'Keepsake' Videos 2Health News:Music Classes Boost Language Skills, Study Says 2Health News:Yoga May Cut Heart Disease Risk Factors 2Health News:Yoga May Cut Heart Disease Risk Factors 3Health News:Water and health advocate Sharon Kleyne adds a “W” for fresh water to “four C’s of skin care” 2Health News:Water and health advocate Sharon Kleyne adds a “W” for fresh water to “four C’s of skin care” 3Health News:JM Ocean Avenue secures the strategic advantages of Veretekk 2Health News:JM Ocean Avenue secures the strategic advantages of Veretekk 3Health News:JM Ocean Avenue secures the strategic advantages of Veretekk 4
... Patient flow leader positioned for expanding role of patient ... Technologies has been helping its clients, now more than ... challenges. The need to increase capacity and improve ... half of U.S. hospitals have postponed building and expansion ...
... likely to suffer bleeding stroke, study finds , , TUESDAY, Jan. ... of brain aneurism are at extreme risk of suffering a ... , The study, backed by the U.S. National ... Jan. 6 issue of Neurology , found that ...
... keep you safe during these cold, snowy monthsROSEMONT, Ill., ... an opportunity to stay inside with a blanket and ... brings with it a whole new excitement of sports ... ice skating, sledding, skiing ( http://orthoinfo.aaos.org/topic.cfm?topic=A00321 ), snowboarding and ...
... Continuing Dental Education ProgramsCHICAGO, Jan. 6 The Academy ... announce a year long partnership to provide quality continuing ... the AGD and Colgate aim to raise awareness for ... as advance the value and excellence of general dentistry ...
... Jan. 6 Mental illness is very troubling for ... incorrectly and symptoms are not alleviated. As a clinician, ... prescribe proper medication, and provide counseling and follow up ... the importance of proper diagnosis and management of psychotic ...
... Solutions, Inc. (Rising), a,leading medical cost containment and ... Medical Data Call services for its clients who,are ... National Council on,Compensation Insurance, Inc. (NCCI). , ... , The Medical Data ...
Cached Medicine News:Health News:TeleTracking Technologies to Focus on Growth 2Health News:TeleTracking Technologies to Focus on Growth 3Health News:Skate Through Winter Sports Injury-Free 2Health News:Skate Through Winter Sports Injury-Free 3Health News:Academy of General Dentistry Partners with Colgate-Palmolive 2Health News:Academy of General Dentistry Partners with Colgate-Palmolive 3Health News:Rising Medical Solutions to Provide NCCI Medical Data Call Services 2
(Date:12/15/2014)... , December 15, 2014 ... Am 19. und 20. Februar sind alle ... SAFE MEDICINE ECOSYSTEM PARTNER PROGRAMM ™ 2015 ... besuchen. Diese Tagung soll dazu ... Möglichkeit geben, die neue profitablen Unternehmensdienstleistungen, die ...
(Date:12/15/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/32cmct/inferior_vena ) has ... (IVC) Filters - Global Trends, Estimates and Forecasts, 2012-2018" ... http://photos.prnewswire.com/prnh/20130307/600769 Global Inferior Vena Cava ... by 2016. The North America ... while Europe claims approximately 27% ...
(Date:12/15/2014)... Israel , Dec. 15, 2014  Immune Pharmaceuticals ... today that its Board of Directors has elected Mr. Daniel ... who continues as Chief Executive Officer of Immune. Mr. ... since 2013. Immune,s new Chairman, Mr. Daniel ... of shareholders and to continue to support the strategic vision ...
Breaking Medicine Technology:Symposium über Aegates Ecosystem-Partner-Programm für sichere Medikamente vom 19. - 20. Februar 2015 in Amsterdam 2Inferior Vena Cava (IVC) Filters - Global Trends, Estimates and Forecasts, 2012-2018 2Inferior Vena Cava (IVC) Filters - Global Trends, Estimates and Forecasts, 2012-2018 3Inferior Vena Cava (IVC) Filters - Global Trends, Estimates and Forecasts, 2012-2018 4Immune Pharmaceuticals Elects Daniel Kazado as New Chairman of the Board. 2Immune Pharmaceuticals Elects Daniel Kazado as New Chairman of the Board. 3Immune Pharmaceuticals Elects Daniel Kazado as New Chairman of the Board. 4
... MYL ) today announced that its subsidiary Matrix ... and Drug Administration (FDA) for its Abbreviated New Drug Application ... 400 mg, the generic version of Pfizer,s Neurontin ® ... Gabapentin Capsules had U.S. sales of approximately $300 ...
... Nile Therapeutics, Inc. (Nasdaq: NLTX ), ... for heart failure patients, today announced plans to collaborate ... the clinical development of Nile,s proprietary natriuretic peptide, cenderitide ... "We are very pleased to partner with ...
Cached Medicine Technology:Nile Therapeutics to Collaborate with Medtronic on Clinical Development of Cenderitide for Heart Failure and Renal Disease 2Nile Therapeutics to Collaborate with Medtronic on Clinical Development of Cenderitide for Heart Failure and Renal Disease 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: