Navigation Links
Recovery from propofol anesthesia may be sped by use of common stimulant
Date:4/5/2012

The ability of the commonly used stimulant methylphenidate (Ritalin) to speed recovery from general anesthesia appears to apply both to the inhaled gas isoflurane, as previously reported, and to the intravenous drug propofol. Members of the same Massachusetts General Hospital (MGH) research team that reported the isoflurane study are publishing similar results for propofol in the May issue of Anesthesiology, and their paper has been issued online.

"Propofol is the most widely used intravenous general anesthetic, and there is currently no way to reverse its effects," says Ken Solt, MD, of the MGH Department of Anesthesia, Critical Care and Pain Medicine, the paper's corresponding author. "By finding that methylphenidate can reverse general anesthesia with propofol as well as with isoflurane, we show that it may be broadly applicable for waking patients up from different general anesthetic drugs."

The MGH team's previous study in the October 2011 issue of Anesthesiology showed that methylphenidate known to affect arousal pathways in the brain and commonly used to treat attention-deficit hyperactivity disorder significantly decreased the amount of time it took for rats to recover from isoflurane anesthesia. The current study ran very similar experiments in which propofol, which has a different mechanism of action than isoflurane, was the anesthetic agent.

In the first experiments, animals that had lost consciousness after a single dose of propofol were given intravenous methylphenidate or saline, and those receiving methylphenidate recovered almost five minutes faster than those receiving saline. Administration of methylphenidate also induced signs of arousal movement or standing up in rats receiving a constant intravenous dose of propofol, while animals administered saline remained motionless. EEG readings of the brains of animals during constant infusion of a higher propofol dose showed that methylphenidate caused brain activity to shift back toward the awake state. The change persisted for up to 10 minutes, during which the animals showed signs of arousal like opening their eyes and kicking, although they did not stand up.

"Propofol can be a very dangerous drug because it can cause patients to stop breathing and their blood pressure to drop," Solt explains. "It is often used for sedation during procedures such as colonoscopies, and if patients get oversedated, methylphenidate may be useful in getting them to wake up and resume breathing and in restoring their blood pressure. In the operating room, where propofol can be administered for several hours, patients may take as long as an hour to recover. The ability to use methylphenidate to induce recovery could make general anesthesia safer and more efficient, and we're hoping to conduct a clinical trial in patients in the near future."


'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Related medicine news :

1. Recovery Act's One Year Anniversary -- 2009 Was Just the Opening Act
2. Federal Recovery Funds Allow Eries Shriners Hospital to Reduce Energy Costs, Invest Savings in Patient Care
3. U.S. Senate Urgently Needs to Extend Medicaid Match in Economic Recovery Legislation
4. Alliance, Inc. Receives Centers of Excellence in Recovery Grant
5. De-Duplication, Compression and No Double Backups Required: AppAssure Releases the Fastest and Most Scalable Backup & Recovery Solution for Microsoft Hyper-V
6. San Francisco Plastic Surgeon Releases Plastic Surgery Patient Recovery Blog
7. Passages to Recovery Outdoor Addiction Treatment Program Achieves Joint Commission Accreditation
8. Economic Recovery and New Healthcare Legislation: The Stars Are Aligned for Increased Adoption of HR Management Systems (HRMS)
9. New Laser Treatment Offers Revolutionary Response to Aesthetic Procedure Candidates' Number One Concern: Recovery Time
10. Arizona Surgeon Performs Hip Replacement Surgery with Fast Recovery, Less Pain
11. Addiction and Recovery: Life Force Dallas
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/6/2019)... ... ... Sponsors Toys for Tots to Give Free Toys to Children in Need , Dr. Alexis ... Holidays , Lasair Aesthetic Health is spreading holiday cheer again this year by sponsoring the ... toys worth more than 25-dollars, will get FIVE units of Botox (a $60 value) for ...
(Date:12/6/2019)... ... December 06, 2019 , ... ... professionals in Baltimore, Maryland at the AES Annual Meeting. The symposium, “Fundamentals of ... 1. Understand methods of quantitative sEMG analysis during ictal events;, 2. Review specific ...
(Date:12/6/2019)... CYPRESS, Calif. (PRWEB) , ... December 06, 2019 , ... ... Health Sciences program, recently published research on the health benefits of coconut oil ... “Coconut Oil Intake and Its Effects on the Cardiometabolic Profile: A Structured Literature Review,” ...
(Date:12/5/2019)... ... December 05, 2019 , ... Abide, the #1 Christian ... million times this year using Bible-based bedtime stories. Listeners have recovered from bad dreams ... to the Center for Disease Control, one third of Americans suffer from poor sleep, ...
(Date:12/5/2019)... ... December 05, 2019 , ... ... has announced the Top 54 RHIT Degree Programs for 2020. The comprehensive research ... the nation. Each program is evaluated based on curriculum quality, graduation rate, reputation, ...
Breaking Medicine News(10 mins):
(Date:12/6/2019)... ... December 06, 2019 , ... The Multiple System Atrophy ... its bold new initiative to kickstart MSA research collaborations. Multiple system atrophy ... Infused by $3 million in new bequests earmarked for research and combined with ...
(Date:12/5/2019)... ... December 05, 2019 , ... LeadingBiotech ,?an ... today announces key issues to be discussed at its East/West CEO ... in San Francisco. , Kicking off the week of the ...
(Date:12/4/2019)... (PRWEB) , ... December 04, ... ... leader in delivering solutions designed for improved financial, operational and clinical health ... earned the Fellow designation from the American College of Healthcare Executives (ACHE). ...
Breaking Medicine Technology: