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Recovery Act dollars are stimulating research at the Medical College of Georgia
Date:12/8/2009

rostate cancer. Data include the genes involved, the proteins the genes make and the metabolites, which suggest which proteins were active. Previously scientists have had snippets of one of more of these compartments, but Dr. Sreekumar and others believe a comprehensive look is needed to get a clear picture of prostate cancer progression.

"There is a lot of crosstalk between genes, proteins and metabolites," he said. "They act, not only independently, they also affect each other. It's like an industry," he said. "You don't want to look at the cell from only one angle. You are really trying to understand the cell, the way it is functioning. When the situation is this complex, you really can't do it any other way."

That means ensuring they are comparing apples to apples. "You have to (determine) a common identifier, so we can say, 'Yes this protein can be compared to this gene,' or 'This metabolite can be compared to this protein,'" Dr. Sreekumar said.

These head-on comparisons should also help scientists identify the most significant missteps, likely the best targets for new therapies.


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Contact: Toni Baker
tbaker@mcg.edu
706-721-4413
Medical College of Georgia
Source:Eurekalert  

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