Navigation Links
Recon 2 modeling may help tailor treatments for patients with metabolic diseases, cancer
Date:3/4/2013

An international team of researchers, including an investigator with the Virginia Bioinformatics Institute at Virginia Tech, has produced what may be the most comprehensive computer model of human metabolism yet developed.

The discovery, detailed Sunday (March 3, 2013) in the journal Nature Biotechnology, advances understanding of human metabolism in health and disease. Called Recon 2, the model builds and improves upon earlier-generation metabolic reconstruction systems and may be useful for finding biomarkers of metabolic diseases, such as glycogen storage disorder, as well as identifying cancer drug targets and predicting unwanted drug side effects.

A variety of models and approaches have co-existed with the common goal of reconstructing human metabolism, but this one connects the dots, adding metabolic information from a variety of databases including content from the DrugBank database, which details the reactions caused by experimental and FDA-approved drugs to individual enzymes and reactions typical of the metabolic system.

"This is important because we are finally mapping the links between the human genome and metabolism," said Pedro Mendes, a computational systems biologist and leader of the Biochemical Networks Modeling Group at the Virginia Bioinformatics Institute. "The results provide a framework that will lead to a better understanding of how an individual's lifestyle, such as diet, or a particular drug they may require, is likely to affect them according to their specific genetic characteristics. The model takes us an important step closer to personalized medicine, where treatments will be tailored according to the patient's genetic and metabolic information."

Scientists from Blacksburg, Va.; Manchester, Cambridge, Edinburgh, Reykjavik, San Diego, Berlin and others mapped 65 human cell types and more than 1,000 enzymes that are known drug targets.

With this new map, researchers will be able to deepen their understanding of the role human metabolism plays in health and disease.


'/>"/>

Contact: Tiffany Trent
ttrent@vt.edu
540-231-6822
Virginia Tech
Source:Eurekalert

Related medicine news :

1. Round or shaped, implants yield good results in breast reconstruction
2. Breast Reconstruction Using Womens Own Tissue Appears Safe: Study
3. 5-year follow-up - over half of all ACL reconstructions could be avoided
4. AxoGen, Inc. Announces Presentation of Avance® Nerve Graft Data at American Society for Peripheral Nerve & American Society for Reconstructive Microsurgery 2013 Meetings
5. AxoGen, Inc. to sponsor Educational Symposium and Panel Discussion at 2013 Annual Meetings of American Association for Hand Surgery, American Society for Peripheral Nerve, and American Society for Reconstructive Microsurgery
6. Tamoxifen trial should prompt breast cancer patients to reconsider treatment options
7. Plastic and Reconstructive Surgery Journal announces global expansion initiatives
8. Reconstructed 1918 influenza virus has yielded key insights, scientists say
9. New survey: Women want to SEE breast reconstruction results before cancer surgery
10. Newer hip reconstruction technique provides good outcomes for athletes
11. ACL reconstruction technique improves outcomes in pediatric patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2017)... (PRWEB) , ... May 26, 2017 , ... ... integration of the CareFusion NOX-T3 portable sleep monitor with its Somnoware Sleep Device ... consistent, browser-based interface for diagnostic device operations. With this platform, initializing devices and ...
(Date:5/26/2017)... ... May 26, 2017 , ... On May 24, the Congressional ... passed the U.S. House on May 4, would result in 23 million Americans losing ... implementation of the 2010 Patient Protection and Affordable Care Act (ACA). , “It ...
(Date:5/26/2017)... (PRWEB) , ... May 26, 2017 , ... Rob Lowe ... An upcoming production of the series is on hiking in American. Viewers can reconnect ... of the great benefits of hiking. , Many consumers have looked for an inventive ...
(Date:5/26/2017)... (PRWEB) , ... May 26, 2017 , ... ... be this year’s recipient of proceeds from its 14th Annual Clays for Kids ... E. County Road 30, Bennett, Colorado. , As part of BluSky’s partnership ...
(Date:5/24/2017)... ... 24, 2017 , ... Last month, representatives from Rendina Healthcare ... town officials to celebrate the grand opening of the 87,000 square foot medical ... of its ongoing relationship with RWJBarnabas Health, New Jersey’s largest health system. Two ...
Breaking Medicine News(10 mins):
(Date:5/10/2017)... May 10, 2017 Global Health Intelligence ... Latin America , published its 2017 ranking of the ... based on extensive data analysis from GHI,s hospitals database ... database for the region. The GHI database covers 86% of ... more than 130 data points for each institution in key ...
(Date:5/9/2017)... 9, 2017 Zimmer Biomet Holdings, Inc. (NYSE ... today announced it has earned a spot on ... The Company was ranked among 500 U.S. employers as ... Healthcare Equipment and Services. The annual ... anonymous, independent survey of over 30,000 employees across 25 ...
(Date:5/8/2017)... YORK , May 8, 2017 ... the transition from fee for service reimbursement. Black Book ... 2017. 1.       The Market for MIPS ... 77% of physician practices with 3 or more ... Technology Solutions by Q4. "Given the magnitude of the ...
Breaking Medicine Technology: