Navigation Links
Receptor protein appears to be key in breakdown of kidney filtration
Date:12/19/2007

to be associated with cellular motility in a number of situations. One of these is the urokinase receptor (uPAR), which is known to be involved in wound healing and inflammation, as well as tumor invasion and metastasis.

Reisers team found that uPAR expression is elevated in glomerular cells of patients with several forms of kidney disease, compared with healthy controls. Animal studies showed that uPAR is expressed in all glomerular cells, yet it does not appear to be required for normal kidney function, since renal function is not compromised in mice lacking the gene for the protein. When the uPAR-knockout mice were treated with a substance that usually induces proteinuria, they did not develop the condition, suggesting that the receptors presence is required for the breakdown of podocyte structure.

After the gene encoding uPAR was introduced into podocytes of the knockout mice, they began expressing the receptor within 24 hours and became susceptible to the proteinuria-inducing treatment. The researchers then showed that uPAR can associate with and activate another receptor protein, alphavbeta3 integrin, leading to podocyte motility. Blocking this step in the uPAR-controlled pathway could reduce or prevent the development of proteinuria in mice. Such an agent is currently in phase II clinical trials for the brain tumor glioblastoma and may become available for use in patients with proteinuria.

Further investigation is required to discover how the uPAR pathway may interact with other molecular mechanisms involved in proteinuria, including the activity of an enzyme called cathepsin L, reported earlier this year by members of the same research team. We are working now in two directions to better understand the relationship between uPAR and cathepsin L and to conduct a clinical trial with small molecules blocking uPAR or alphavbeta3 integrin, says Reiser, an assistant professor of Medicine at Harvard Medical School. We hope this
'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Investigational Agent Targeting Metabotropic Glutamate 2/3 Receptors Demonstrates Antipsychotic Activity in Humans, Study in Nature Medicine Finds
2. Low level of neuronal receptor linked to mild cognitive impairment and Alzheimers disease
3. Pathway Diagnostics Announces Commercial Availability of SensiTrop(TM) HIV Co-receptor Tropism Assay
4. Pharmacopeia Acquires Selective Androgen Receptor Modulator (SARM) Program from Bristol-Myers Squibb
5. Food restriction increases dopamine receptor levels in obese rats
6. Quest Diagnostics Licenses Technology Underlying SensiTrop(TM) HIV Co-Receptor Tropism Test from Pathway Diagnostics
7. Abbott Researchers Target Neuronal Nicotinic Receptors for Treatment of Pain and Cognition
8. Exelixis to Receive Milestone Payment From Bristol-Myers Squibb for Achievement of Liver X Receptor Agonist Development Milestone
9. Draining away brains toxic protein to stop Alzheimers
10. Penn study finds pro-death proteins required to regulate healthy immune function
11. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... appears to increase the risk for head and neck cancer ... with DM, but the risk of HNC in patients with ... cancer is the sixth most common type of cancer. It ... an estimated 650,000 new cancer cases and 350,000 cancer deaths ... Insurance Research Database to examine the risk of HNC in ...
(Date:7/24/2014)... This year the Walk to End Alzheimer’s ... National Life, will be held on Saturday, September 20 in ... Fun Run at 7:50 am, the untimed 5k Run at ... “The Walk to End Alzheimer’s unites the entire community in ... against this devastating disease, “stated Linda Mitchell, CEO and president ...
(Date:7/24/2014)... two or more equally positive outcomes experience paradoxical ... activity in different regions of the brain, according ... research scholar at the Princeton Neuroscience Institute at ... people rated the desirability of more than 300 ... at images of paired products with different or ...
(Date:7/24/2014)... 24, 2014 Memantine was initially developed by ... in Germany under the brand name Akatinol; it was later ... Ebixa and in the USA to Forest Labs as Namenda. ... in 2013. In the US, Forest reported Namenda sales of ... in Canada, Australia and the European region has increased the ...
(Date:7/24/2014)... scientists at Carnegie Mellon University, working with high-throughput ... Berkeley National Laboratory, have devised a computational method ... normal breast cells turn malignant and as they ... for analyzing how genes interact with each other ... published today by the online journal PLOS ...
Breaking Medicine News(10 mins):Health News:Alzheimer's Association Walk to End Alzheimer's Steps Off Saturday, September 20 in Denver 2Health News:Alzheimer's Association Walk to End Alzheimer's Steps Off Saturday, September 20 in Denver 3Health News:Brain's dynamic duel underlies win-win choices 2Health News:Brain's dynamic duel underlies win-win choices 3Health News:Memantine Discussed in New Comprehensive Patent Search Report by Ark Patent Intelligence Published at MarketPublishers.com 2Health News:Memantine Discussed in New Comprehensive Patent Search Report by Ark Patent Intelligence Published at MarketPublishers.com 3Health News:Gene changes in breast cancer cells pinpointed with new computational method 2Health News:Gene changes in breast cancer cells pinpointed with new computational method 3
... people, mainly in developing countries, are disabled by infectious ... More than 12 million people in 88 countries are ... bite of infected sand flies. Nearly 2 million new ... the disease annually. , Researchers at the University ...
... Can a high-energy diet pill really save your job? ... manufacturers, clothing makers and other retailers are seeing a significant ... maker Zoller(R) Laboratories is reporting dramatically increased sales of ... , (Photo: http://www.newscom.com/cgi-bin/prnh/20081216/LA52707 ) , ...
... Targeting pigments in mucus could fight deadly,bacteria in lungs ... called phenazines that stain the mucus in the lungs ... spur dangerous infections, researchers say. , The pigments may ... into structured communities, according to a Massachusetts Institute of ...
... from and odds are that they know. Or maybe not. A new ... tools to scan the human genome must pay attention to ancestry when ... ... 2008 -- Ask someone where their ancestors were from and odds ...
... Institutes of Health (NIH) has awarded nearly $3 million to ... milk impacts the health outcomes and health care cost savings ... 1500 grams. , The grant will enable researchers at ... cohort of 600 very low birth weight infants born to ...
... there,s a scientific reason why older people tend to ... A University of Alberta medical researcher, in collaboration with ... older adults to remember fewer negative events than their ... than younger people when it comes to storing memory, ...
Cached Medicine News:Health News:UIC researchers hunting drugs for devastating parasitic disease 2Health News:Sales of Energy-Boosting Diet Pills Skyrocket as the Economy Falters 2Health News:Scientists Spot Key to Cystic Fibrosis Infections 2Health News:Genome-wide Association Studies Must Account for Ancestry 2Health News:Genome-wide Association Studies Must Account for Ancestry 3Health News:Study examines how breastfeeding impacts cost of care for very low birth weight infants 2Health News:Aging brains allow negative memories to fade 2
(Date:7/24/2014)...  Restore Health, a leading personalized medicine company ... it is now offering pharmacogenetics testing that provides ... upon their particular genetic makeup. Comprehensive medication management ... a patient,s genetics and their entire drug regimen.  ... this new service to healthcare providers and their ...
(Date:7/24/2014)... -- Uroplasty, Inc. (NASDAQ: UPI ), a medical ... proprietary products to treat voiding dysfunctions, today reported ... ended June 30, 2014.  Global revenue for ... 19% to $4.1 million, as compared to $3.4 ... year.  Total revenue for the fiscal first quarter ...
(Date:7/24/2014)... July 24, 2014  IRIDEX Corporation (NASDAQ: ... second quarter 2014 financial results after the market closes ... with the release, the Company will host a conference ... Eastern Time on Thursday, July 31, 2014 ... other business developments. Interested parties may access ...
Breaking Medicine Technology:Restore Health Launches Pharmacogenetic Testing, Enhancing Its Suite of Personalized Medicine Goods and Services 2Restore Health Launches Pharmacogenetic Testing, Enhancing Its Suite of Personalized Medicine Goods and Services 3Uroplasty Reports Fiscal First Quarter Results 2Uroplasty Reports Fiscal First Quarter Results 3Uroplasty Reports Fiscal First Quarter Results 4Uroplasty Reports Fiscal First Quarter Results 5Uroplasty Reports Fiscal First Quarter Results 6Uroplasty Reports Fiscal First Quarter Results 7Uroplasty Reports Fiscal First Quarter Results 8Uroplasty Reports Fiscal First Quarter Results 9Uroplasty Reports Fiscal First Quarter Results 10Uroplasty Reports Fiscal First Quarter Results 11
... , REDWOOD CITY, Calif., Dec. 24 Maxygen, Inc. ... development of improved versions of protein drugs, today announced the ... expired at 5:00 p.m., New York City time, on December ... by the depositary for the tender offer, Maxygen expects to ...
... , , GREENSBORO, N.C., Dec. 23 ... four users who allege kidney damage due to the use ... in preparation for a colonoscopy. (Holshouser et al v. ... are against two Morrisville, N.C., pharmaceutical companies, Salix Pharmaceuticals, Ltd., ...
Cached Medicine Technology:Maxygen, Inc. Announces Preliminary Results of Dutch Auction Tender Offer 2Suits Commenced Against Maker of Prescription Cleansing Drug 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: