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Recently Published Study Demonstrates Pharmacokinetic Advantages of ENDOMETRIN(R) Over Crinone(R) for Progesterone Supplementation
Date:8/31/2009

eady state by 5 days. At 5 days, the Endometrin(R) treatments produced sustained progesterone concentrations exceeding 10 ng/mL across 24 hours. The results suggest that ENDOMETRIN((R)) can reach a targeted concentration range in a substantially shorter time than Crinone. Both ENDOMETRIN(R) groups demonstrated a higher C(max)( )than the Crinone group, with greater systemic exposures. Both the vaginal inserts and the gel were generally safe and well tolerated, and all adverse events were mild.

About ENDOMETRIN

ENDOMETRIN(R) administered as a progesterone vaginal insert is indicated to support embryo implantation and early pregnancy by supplementation of corpus luteal function as part of an Assisted Reproductive Technology (ART) treatment for infertile women.

Important Safety Information

Only physicians thoroughly familiar with infertility treatment should prescribe ENDOMETRIN(R). In clinical trials (n=808), adverse reactions that occurred at a rate greater than or equal to 2 percent included: uterine spasm (3% to 4%) and vaginal bleeding (3%). Vaginal irritation, itching, burning or discomfort, urticaria, and peripheral edema were reported at an incidence of less than 2 percent. ENDOMETRIN(R)( )is expected to have adverse reactions similar to other drugs containing progesterone (breast tenderness, bloating, mood swings, irritability, and drowsiness). ENDOMETRIN(R)( ) is contraindicated in women who have or have had previous allergic reactions to progesterone or any of the ingredients in ENDOMETRIN(R)( ); a known missed abortion or ectopic pregnancy; liver disease; known or suspected breast cancer; active arterial or venous thromboembolism or severe thrombophlebitis, or a history of these events.

About Ferring Pharmaceuticals

Ferring Pharmaceuticals, part of the Ferring Group, a privately owned, international pharmaceutical company, manufactures and markets th
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SOURCE Ferring Pharmaceuticals
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