Navigation Links
Recent findings may help to fight melanoma's resistance to chemotherapy
Date:10/31/2012

This press release is available in French.

Blocking the action of a particular protein in our skin could improve the treatment of skin cancers, according to a study published in Oncogene yesterday by Philippe Roux, a researcher at the University of Montreal's Institute for Research in Immunology and Cancer (IRIC). "Our findings reveal part of the mechanisms responsible for the resistance of melanoma to anti-cancer treatments, and suggest that a particular protein in our bodies called RSK may be targeted in combination therapies to overcome drug resistance," Roux explained.

Although melanoma accounts for only 4% of all skin cancers, it is responsible for 80% of skin cancer-related deaths worldwide as it is highly invasive and resistant to conventional chemotherapies. Melanoma originates from pigment-producing cells, called melanocytes, located in the skin. The incidence of malignant melanoma is growing rapidly worldwide and there is still no effective therapy to treat it. Approximately 160,000 new cases of the disease are diagnosed each year.

Roux and his team focused their research on a signaling pathway called Ras/MAPK, which is often deregulated in melanoma, but also in lung, colon and pancreatic cancers. A signaling pathway is a chemical chain reaction that causes the cells in our bodies to act in a certain way. In this study, Roux and his team found that a protein in the Ras/MAPK pathway, RSK, contributes to chemoresistance by altering the response of cancer cells to chemotherapeutic agents.

This is the second Oncogene publication for Philippe Roux this year. In a paper published in July, Roux and his colleagues, IRIC Principal Investigators Katherine Borden and Sylvain Meloche, demonstrated that the same protein involved in chemoresistance contributes to melanoma growth, making the protein RSK a promising therapeutic target for treating the disease.


'/>"/>

Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-343-7593
University of Montreal
Source:Eurekalert

Related medicine news :

1. Recent Report Reveals Dramatic Increase in Chronic Disease in Pets
2. Columbus Allergist Dr. Summit Shah Discusses Recent Findings on Food Allergies and Exercise-Induced Anaphylaxis
3. Greater numbers of highly educated women are having children, bucking recent history
4. New findings on mens genes could alter interpretation of PSA test
5. Unexpected findings at multi-detector CT scans: Less reason to worry
6. MRI findings shed light on multiple sclerosis
7. New findings by GW researcher break tanning misconceptions: There is no such thing as a safe tan
8. Relief for Migraine Sufferers as The Life House Offers New Findings, Free Consults
9. Once-Banned Bird Flu Study Yields Sobering Findings
10. Mayo Clinic urologists present findings at American Urological Association Annual Meeting
11. Researchers present new findings for novel pancreatic cancer vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2017)... OH (PRWEB) , ... May 24, 2017 , ... Dr. ... and comfortable ClearCorrect orthodontics, with or without a referral. Dr. Kejriwal understands ... why she offers convenient, clear braces in Cincinnati, OH. Patients no longer need to ...
(Date:5/24/2017)... (PRWEB) , ... May 24, 2017 , ... Myers Jackson ... his has the ability to sell luxury homes anywhere on the planet. The luxury ... county side from Hattiesburg to Houston city-scapes. A quick search of “11 Spyglass Hill ...
(Date:5/24/2017)... (PRWEB) , ... May 24, 2017 , ... Medic ... Kids: The Surprising Truth about Pediatric Septic Shock” hosted by the Journal of Emergency ... at 2 p.m. Eastern time, will be presented by Captain Rommie Duckworth, LP, a ...
(Date:5/24/2017)... Massapequa Park, NY (PRWEB) , ... May 24, ... ... today announced the practice is offering holistic pediatric dentistry options for its patients ... the context of the patient’s entire physical well being, and is one of ...
(Date:5/24/2017)... River Falls, Wisconsin (PRWEB) , ... May 24, ... ... market leader in clean label food ingredient solutions for the food and beverage ... consumers factor in food ingredient statements during the purchasing decision process. As a ...
Breaking Medicine News(10 mins):
(Date:5/4/2017)... --  BioLife Solutions , Inc. (NASDAQ: BLFS ... clinical grade hypothermic storage and cryopreservation ... that the Company,s first quarter 2017 financial results will ... 2017, and that the Company will host a conference ... afternoon. Management will provide an overview of the Company,s ...
(Date:5/3/2017)... , May 3, 2017  Getinge, a ... contribute to quality enhancement and cost efficiency within ... a study of contemporary practice demonstrating that intra-aortic ... therapy for critically ill patients. The single-center, retrospective, ... newer large volume MEGA ® 50cc intra-aortic ...
(Date:5/2/2017)...  George Clinical, a leading full-service CRO in the ... Oncology, a Memphis -based leader ... that George Clinical has acquired Vector Oncology,s Pharma Services (CRO) ... purpose of strengthening the ability of George Clinical ... throughout the Asia-Pacific , the ...
Breaking Medicine Technology: