Navigation Links
Rebuilding the brain's circuitry
Date:11/24/2011

insulin and glucose, these neurons had effectively joined the brain's network and rewired the damaged circuitry.

"It's interesting to note that these embryonic neurons were wired in with less precision than one might think," Flier said. "But that didn't seem to matter. In a sense, these neurons are like antennas that were immediately able to pick up the leptin signal. From an energy-balance perspective, I'm struck that a relatively small number of genetically normal neurons can so efficiently repair the circuitry."

"The finding that these embryonic cells are so efficient at integrating with the native neuronal circuitry makes us quite excited about the possibility of applying similar techniques to other neurological and psychiatric diseases of particular interest to our laboratory," said Anderson.

The researchers call their findings a proof of concept for the broader idea that new neurons can integrate specifically to modify complex circuits that are defective in a mammalian brain.

The researchers are interested in further investigating controlled neurogenesis -- directing growth of new neurons in the brain from within -- the subject of much of Macklis's research as well as Flier's 2005 paper, and a potential route to new therapies.

"The next step for us is to ask parallel questions of other parts of the brain and spinal cord, those involved in ALS and with spinal cord injuries," Macklis said. "In these cases, can we rebuild circuitry in the mammalian brain? I suspect that we can."


'/>"/>
Contact: David Cameron
david_cameron@hms.harvard.edu
617-960-7221
Harvard Medical School
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Clinton Bush Haiti Fund Awards International Medical Corps $500,000 for Emergency Medical Care and Long-Term Rebuilding
2. Protecting our brains: Tackling delirium
3. The serotonin system in womens brains is damaged more readily by alcohol than that in mens brains
4. Former Football Players Brains May Benefit From Healthy Lifestyle
5. Imaging technique IDs plaques, tangles in brains of severely depressed older adults
6. It takes two: Brains come wired for cooperation, neuroscientist asserts
7. Links to Mental Illness Seen in Fetal Brains: Study
8. Autistic brains develop more slowly than healthy brains UCLA researchers say
9. Screen-Free Play Best for Toddlers Brains
10. Stress May Affect Preemies Brains, Study Shows
11. Key regulatory genes often amplified in aggressive childhood tumor of the brainstem
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2015)... RF Technologies®, a leading provider of personal safety ... Solution with Voice Alarms. The ST750 will play a ... wait for assistance when it detects them starting to ... different melodies or tones or silent alerting, by integrating ... Alert®. , For 28 years, Sensatec Fall Management ...
(Date:5/5/2015)... Rafael, CA (PRWEB) May 05, 2015 ... in 2012, with the belief that ultimate Frisbee™ is ... be the next sport that engages the world. Nike ... youth level, by creating opportunities for young athletes to ... this collaboration with MLU the perfect fit. , The ...
(Date:5/5/2015)... 05, 2015 NovaSom, Inc., announced today ... of Innovations with Ed Begley Jr., airing via Discovery ... , This segment will focus on NovaSom, a leader ... learn about their AccuSom® home sleep test, which is ... continuous patient support and next-day test results and interpretation. ...
(Date:5/5/2015)... 2015 Every year, news articles appear warning ... the worst dry eye season is spring, also known as ... of the United States. The only season offering a respite ... Kleyne, host of the Sharon Kleyne Hour™ Power of Water® ... show of May 11, 2015. Kleyne is the inventor of ...
(Date:5/5/2015)... 05, 2015 McMunn Associates , ... automation solutions, announced today that it has officially launched ... identity. According to president and founder, Larry McMunn, the ... the company’s strategy for growth and expansion for the ... the past 30 years by building close, personal relationships ...
Breaking Medicine News(10 mins):Health News:RF Technologies® Releases Sensatec® ST750 Voice Alarm for Fall Management 2Health News:RF Technologies® Releases Sensatec® ST750 Voice Alarm for Fall Management 3Health News:US Sports Camps, Nike Ultimate Camps, and Major League Ultimate Host Youth Ultimate Summer Camps in Philidelphia 2Health News:Innovations with Ed Begley, Jr. to Explore NovaSom, Inc., in Upcoming Episode 2Health News:Nature’s Tears EyeMist tear film supplement soothes dry eye caused by spring pollen season, reports inventor Sharon Kleyne 2Health News:Nature’s Tears EyeMist tear film supplement soothes dry eye caused by spring pollen season, reports inventor Sharon Kleyne 3Health News:McMunn Associates Launches New Corporate Branding with New Website 2
... treatments, better patient outcomes , , WEDNESDAY, March 12 (HealthDay ... patients at risk of developing acute kidney injury (AKI) ... problem would otherwise be detected, a pilot study shows. ... better patient outcomes, the researchers say. , The test ...
... sights on renewed growth, IRWINDALE, Calif., March 12 ... including diet bars and,powdered mixes, today announced the appointment ... and consumer products sectors: Allan,Lutz, Scott Meader and Hugh ... of the company., Mr. Lutz has more than ...
... first "test-tube" baby was born in July 1978 - the ... couples in developed countries. There, we have seen more than ... in some countries, as many as 4 per cent of ... The plight of couples in developing countries, especially women, has ...
... market, WASHINGTON, March 12 Groundbreaking research,on ... impact on Medicare costs. The new study by,America,s ... in the,journal Health Affairs. AHIP also released a ... Medigap enrollment has remained constant in recent,years, showing ...
... ISTA,Pharmaceuticals, Inc. (Nasdaq: ISTA ), today announced ... Health Care Conference at 3:55 p.m. Eastern,Daylight Time on ... Hotel,in Boston, MA., ISTA,s President and Chief Executive ... the Company,s commercial and clinical,progress. To access the live ...
... announces Progress in Osteoporosis now available FREE online , ... mouse click away , The International Osteoporosis Foundation has ... is now available free online to help readers keep ... developments. , Progress in Osteporosis provides a timely update ...
Cached Medicine News:Health News:New Test Predicts Risk of Post-Surgery Kidney Injury 2Health News:Nellson Nutraceutical Names New Directors and Interim Chief Executive Officer 2Health News:Fertility in developing countries: words into action 2Health News:New AHIP Study in Health Affairs Challenges Previous Assumptions About Medigap's Impact on Medicare Costs 2Health News:New AHIP Study in Health Affairs Challenges Previous Assumptions About Medigap's Impact on Medicare Costs 3
(Date:5/5/2015)... Bio-Techne Corporation (NASDAQ: TECH ) announced ... a dividend of $0.32 per share for the quarter ... payable May 29, 2015 to all common shareholders of ... be considered by the Board of Directors on a ... ) is a global life sciences company providing innovative ...
(Date:5/5/2015)... 5, 2015  InMed Pharmaceuticals Inc. ("InMed") (CSE: ... that specializes in developing safer, more effective cannabis-based ... investor, and Non-Executive Director, Peter Mountford , ... with primary responsibility for the European markets. ... leverage his previous success in the emerging field ...
(Date:5/4/2015)... May 4, 2015  Xencor, Inc. (NASDAQ: ... monoclonal antibodies for the treatment of autoimmune diseases, ... financial results for the first quarter ended March 31, ... "Following our equity offering in February, ... we are in a strong financial position to ...
Breaking Medicine Technology:InMed Engages Peter Mountford as Strategic Advisor 2InMed Engages Peter Mountford as Strategic Advisor 3InMed Engages Peter Mountford as Strategic Advisor 4Xencor Reports First Quarter 2015 Financial and Operating Results 2Xencor Reports First Quarter 2015 Financial and Operating Results 3Xencor Reports First Quarter 2015 Financial and Operating Results 4Xencor Reports First Quarter 2015 Financial and Operating Results 5Xencor Reports First Quarter 2015 Financial and Operating Results 6Xencor Reports First Quarter 2015 Financial and Operating Results 7Xencor Reports First Quarter 2015 Financial and Operating Results 8
... the journal Blood found 92 percent reduction in ... ... Patients with a rare,blood disorder called PNH experienced a 92 ... treatment,with Soliris(TM) (eculizumab), according to an analysis of clinical studies,recently ...
... Groundbreaking 2002 ... ... study reveals that,coiling, a minimally invasive procedure to treat aneurysms in ... treatment in those aneurysms considered "untouchable" by the,traditional surgical option. One ...
Cached Medicine Technology:PNH Patients Treated with Soliris(TM) Experienced Dramatic Reduction in Blood Clots During Clinical Trials 2PNH Patients Treated with Soliris(TM) Experienced Dramatic Reduction in Blood Clots During Clinical Trials 3PNH Patients Treated with Soliris(TM) Experienced Dramatic Reduction in Blood Clots During Clinical Trials 4PNH Patients Treated with Soliris(TM) Experienced Dramatic Reduction in Blood Clots During Clinical Trials 5PNH Patients Treated with Soliris(TM) Experienced Dramatic Reduction in Blood Clots During Clinical Trials 6PNH Patients Treated with Soliris(TM) Experienced Dramatic Reduction in Blood Clots During Clinical Trials 7PNH Patients Treated with Soliris(TM) Experienced Dramatic Reduction in Blood Clots During Clinical Trials 8New Study Proves That Minimally Invasive Aneurysm Treatment Yields Successful Long-Term Results 2New Study Proves That Minimally Invasive Aneurysm Treatment Yields Successful Long-Term Results 3
... RiOs systems produce Type III, laboratory-grade ... Systems are fed directly with potable tap ... a compact system design that is easy ... over the water produced at a low ...
... ArcticTemp Ultra Low Freezers -85C offer efficiency ... Features: Compressor life is extended by an ... a constant flow of refigerant. Heat is ... condenser with three fans. Monitoring light to ...
... U570 is an upright freezer, built ... models. Comparable in size to Innova ... cascade refrigeration and urethane insulation, for ... 400 2" boxes. Includes five compartments ...
... freezer, with over 23 cu. ft. storage ... Built to the same standards as Innova ... cost-saving alternative. Rust-resistant, powder coated exterior; top-quality ... adjustable shelves. Keyed lock and 4-digit password ...
Medicine Products: