Navigation Links
Rebuilding the brain after stroke

DETROIT Enhancing the brain's inherent ability to rebuild itself after a stroke with molecular components of stem cells holds enormous promise for treating the leading cause of long-term disability in adults.

Michael Chopp, Ph.D., Scientific Director of the Henry Ford Neuroscience Institute, will present this approach to treating neurological diseases Thursday, Feb. 13, at the American Heart Association's International Stroke Conference in San Diego.

Although most stroke victims recover some ability to voluntarily use their hands and other body parts, half are left with weakness on one side of their body, and a substantial number are permanently disabled.

No treatment currently exists for improving or restoring this lost motor function in stroke patients, mainly because of mysteries about how the brain and nerves repair themselves.

But Dr. Chopp and other Henry Ford scientists may have solved some of these mysteries through experiments at the molecular level identifying and testing components of stem cells.

"Even in older people, the central nervous system is highly plastic, meaning it has a unique ability to change and rebuild itself," Dr. Chopp explains. "We have demonstrated that this plasticity can be stimulated to promote neurological recovery after a stroke."

One such therapy involves proteins that shape the developing brain, specifically a type that releases tissue plasminogen activator, or tPA, which causes axons and dendrites the brain's neural cables and communications network to rewire.

"We have shown that administering tPA in a nasal spray promotes this rewiring and significantly enhances neurological recovery," Dr. Chopp says.

Dr. Chopp will also speak at the AHA conference about other microscopic material in stem cells called exosomes that offer a "robust" treatment for stroke's crippling effects.

These blister-like microscopic "bubbles" were once were thought to carry and get rid of "old" proteins that were no longer needed by the body. However, exosomes were recently found to provide an essential form of "communication" between brain cells using "packages" sent out by stem cells with vital directions for gene regulation.

This is done through microRNA, master molecular switches that alter brain cells and promote recovery from trauma.

Dr. Chopp and his team have shown and confirmed that stem cell therapy works by firing off these "information bullets."

But they have also shown that neurological diseases can be treated with exosomes alone, separate from stem cells.

"This approach may be a revolutionary way to successfully treat stroke and many other diseases," Dr. Chopp says.


Contact: Dwight Angell
Henry Ford Health System

Related medicine news :

1. Kessler Foundation presents Brain Injury: From Research to Rebuilding Lives on Sept. 27-28
2. Rebuilding a whole heart for children born with only half of 1
3. Rebuilding blood vessels through gene therapy
4. Spargo Group and DORMA Lock Down Residential Improvements, Supporting Rebuilding Together Efforts in Chicago
5. Study Suggests Vaccine May Help Kids With Brain Cancer
6. Epilepsy Leads to More Brain Abnormalities Over Time
7. UCLA Brain Injury Research Center gets NCAA funding for research on sports concussions
8. Why is traumatic brain injury increasing among the elderly?
9. Brain Falters Near End of Life, but Games, Puzzles Might Slow Decline
10. Dental X-Rays May Be Linked to Benign Brain Tumors
11. Nonsurgical Method to Measure Brain Pressure Shows Promise
Post Your Comments:
(Date:10/13/2015)... ... October 13, 2015 , ... Relay ... messaging application, announced today a significant contract that will provide its award-winning private ... to build on the growing success of its Relay program, IBX Wire™, which ...
(Date:10/13/2015)... ST. LOUIS and CHENNAI, India (PRWEB) , ... October 13, 2015 ... ... the development of advanced camera solutions, today announced See3CAM_CU40, the industry’s first ... stand-alone MIPI CSI-2 module. See3CAM_CU40, a new member of e-con’s See3CAM family of UVC ...
(Date:10/13/2015)... ... October 13, 2015 , ... A child without a healthy ... SmileCareClub , the leading remote invisible aligner system, has joined with Global Dental ... without it. For each aligner treatment plan purchased, SmileCareClub will donate one clinic visit ...
(Date:10/13/2015)... ... October 13, 2015 , ... Protein is essential to good health. ... bone, and blood. But how much protein does the average man need in order ... according to the October 2015 issue of Harvard Men's Health Watch . Most ...
(Date:10/13/2015)... ... October 13, 2015 , ... Nordic ... unique health needs of new moms. Postnatal Omega-3, which has been named ... utilizes Nordic Naturals’ exclusive, new, ultra-concentrated omega-3 oil. This breakthrough oil combines ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... YORK , Oct. 13, 2015 Pomerantz ... filed against Amicus Therapeutics, Inc. ("Amicus" or the "Company")(NASDAQ: ... filed in United States District Court, District of ... a class consisting of all persons or entities who ... 1, 2015 inclusive (the "Class Period"). This class action seeks ...
(Date:10/13/2015)... BOSTON , Oct. 13, 2015 ... lawsuits against GlaxoSmithKline (GSK) related to the pharmaceutical ... defects alleged to have been caused by their ... profile of this drug for pregnant women.   Due ... lawsuits against GSK, The United States Judicial Panel ...
(Date:10/13/2015)... Oct. 13, 2015 VIVA Physicians, a not-for-profit ... and intervention through education and research, is excited to ... 2015 . Sixteen trial results, featuring the latest in ... first time on Monday and Tuesday, November 2 and ... --> --> Since 2003, VIVA Physicians ...
Breaking Medicine Technology: