Navigation Links
Rebuilding blood vessels through gene therapy
Date:12/21/2012

NEW YORK (Dec. 20, 2012) -- Diagnosed with severe coronary artery disease, a group of patients too ill for or not responding to other treatment options decided to take part in a clinical trial testing angiogenic gene therapy to help rebuild their damaged blood vessels. More than 10 years later, in a follow-up review of these patients, doctors at Baylor College of Medicine, Weill Cornell Medical College (where the clinical trial and review took place) and Stony Brook University Medical Center report the outcomes are promising and open the door for larger trials to begin.

The study, which appears online in the journal Human Gene Therapy, followed 31 Weill Cornell patients who were diagnosed with severe coronary artery disease and were given a direct injection into their heart muscle of gene therapy called adenovirus encoding angiogenic growth factor, or AdVEGF121. Study results show the five- and 10-year survival rate of those patients were just as good and, in some cases better, than what is seen in other groups with similar heart issues treated with traditional medical therapy.

"The results of this 10-year gene therapy study are important," said co-senior author Dr. Ronald G. Crystal, chairman and professor of Genetic Medicine at Weill Cornell Medical College. "After long-term follow-up, the patients who received angiogenic gene therapy appear to have improved outcomes. The study results give us greater insight into the safety and effectiveness of gene therapy to rebuild blood vessels in patients living with coronary artery disease."

"At the time when the trial began, there were no comparisons available to tell us what to expect, which is why we are so pleased with the results," said co-senior author Dr. Todd Rosengart, professor and chair of the Michael E. DeBakey Department of Surgery at Baylor College of Medicine, formerly of Stony Brook University Medical Center. "We only had an idea of what the outcome might be based on
'/>"/>

Contact: Lauren Woods
Law2014@med.cornell.edu
646-317-7401
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. Rebuilding a whole heart for children born with only half of 1
2. Kessler Foundation presents Brain Injury: From Research to Rebuilding Lives on Sept. 27-28
3. FDA: Dont Use Pradaxa Blood Thinner in Patients With Artificial Heart Valves
4. Steering stem cells to become 2 different building blocks for new blood vessels
5. US Drug Watchdog Now Urges All DePuy Pinnacle Hip Implant Recipients To Call Them For The Names Of The Best Law Firms If A Blood Test Indicates Elevated Metal Levels
6. Temple researcher shows diabetes, blood pressure link to colon cancer recurrence, survival
7. US Drug Watchdog Now Urges Yaz Yasmin Birth Control Pill Users Who Suffered a Stroke, Blood Clots, or a Heart Attack to Call the Johnson Law Group for a Legal Review
8. MyBloodWorks Creator Glen Ogle Comments on New Study Linking Hypertension During Pregnancy to Later Heart Trouble
9. US Drug Watchdog Now Urges All DePuy Pinnacle Metal On Metal Hip Implant Recipients To Get A Blood Test That Zeros In On Cobalt and Chromium levels
10. Mayo Clinic-led study unravels biological pathway that controls the leakiness of blood vessels
11. New technology allows scientists to capture and preserve cancer cells circulating in the bloodstream
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/19/2013)... California (PRWEB) May 19, 2013 According to ... Body Firmers” many people are self-conscious about the appearance of ... an option when diet and exercise fail to tone and ... may appeal to those looking to get the firmest ... is an effective mini-overview,” says Dr. Simon Ourian, Medical Director ...
(Date:5/19/2013)... St. Louis, MO (PRWEB) May 19, 2013 ... Member Conference, May 19-22, 2013, at the Walt Disney ... the latest trends in supply chain innovation, care delivery ... a much different dynamic in all healthcare markets, ... necessary part of the conversation,” said Todd Ebert, Amerinet ...
(Date:5/19/2013)... Omaha, Nebraska is a city of diversity, economic growth ... the lowest unemployment rates in the country. Forbes Magazine distinguished ... Business and Careers and it consistently scores high on many ... in the nation and is a strong business leader thanks ... Editions TV are pleased to announce air dates ...
(Date:5/19/2013)... in Minnesota have a great option to get in shape ... Fat Loss Formula. The best part is people can ... The product sells for $135 dollars and is an immediate ... http://altmanfitness.com/28-day-fat-loss-formula/ , “Bikini season is almost here. People may ... the 28 Day Fat Loss Formula they will be happy ...
(Date:5/19/2013)... 2013 In partnership with the medical practice ... the launch of an SEO website for dentists. The purpose ... in Google. , http://www.e-dentists.com/ , A perk to ... service until they see results. Dentists can request the keywords ... run by JD Media Surge, LLC rank high for competitive ...
Breaking Medicine News(10 mins):Health News:Body Firming – The Hottest Treatments Available 2Health News:Healthcare Leaders Gather at 2013 Amerinet Member Conference to Share New Ways to Reduce Costs and Enhance Care Delivery 2Health News:Editions TV Announces May Air Dates for Omaha, Nebraska 2Health News:Effective New Dental SEO Solution Launched by E-dentists.com in Partnership with JD Media Surge, LLC 2
... According to a new federal report, in spite of the ... several new programs to overcome it//, the efficacy of these ... efforts need national leadership, according to the report, Progress in ... Institute of Medicine. This report was released yesterday. ...
... revealed that there is a “crisis” over lack of donors at ... clinics being totally out of stock//, women and couples wanting to ... the highest number of donors was 459. Ever since, the number ... law was passed that gave kids the right to know the ...
... week the distribution of a drug to help fight an ... is being affected by an extremely virulent strain of tuberculosis, ... the country. The health officials have now promised that they ... week to help fight the disease. The officials but also ...
... for an extensive study for the evaluation of the possible ... stents. // ,Stents are widely used heart devices ... had essentially eliminated short-term restenosis as a complication of coronary ... cloud for possible late-term risks. Reports indicate that almost 6 ...
... unique way to curb binge drinking, researchers say parents should allow ... youngsters // to drink at parties and at home may be ... ,Professor Mark Bellis, the author of the report said that children ... and allowed to drink with them were sensible in their approach ...
... a safe way to monitor the fate of transplanted ... issue of the journal Diabetes. // Researchers from the ... (MGH) said that they were able to track transplanted ... human transplants. ,"Clinical trials and animal studies ...
Cached Medicine News:Health News:Slow Fight Against Childhood Obesity 2Health News:Slow Fight Against Childhood Obesity 3Health News:Shortage of donors at sperm bank clinics 2Health News:South Africa To Make Available Two New Drugs To Fight The TB Outbreak 2Health News:MRI Can Monitor Transplanted Islets 2
(Date:5/17/2013)... Rico , May 17, 2013  Serving a region ... Puerto Rico , Caribbean Imaging and Radiation Therapy (CIRT, ... radiation therapy capabilities with the acquisition of an Elekta Versa ... . Versa HD offers clinicians the versatility to deliver conventional ... body, while also enabling treatment of highly complex cancers that ...
(Date:5/17/2013)... PARIS , May 17, 2013  Sanofi (EURONEXT: ... the pivotal study, JAKARTA , examining ... its primary endpoint in both dose groups. The primary ... of spleen volume. Consistent with data reported in previous ... nausea and vomiting. Full results will be presented at ...
(Date:5/16/2013)... NORTH CHICAGO, Ill. and MECHELEN, ... NV (Euronext: GLPG) and AbbVie (NYSE: ABBV ... development collaboration to include Crohn,s disease.  Galapagos will fund ... which is designed to facilitate rapid progression into Phase ... Q2 2015, AbbVie will pay Galapagos $50 million.  The ...
Breaking Medicine Technology:Puerto Rico's Caribbean Imaging and Radiation Therapy Center Orders Elekta's New Versa HD System for Treatment of Cancer Patients 2Sanofi Reports Positive Topline Results from Pivotal Phase III JAKARTA Study for JAK2 Inhibitor in Myelofibrosis 2Sanofi Reports Positive Topline Results from Pivotal Phase III JAKARTA Study for JAK2 Inhibitor in Myelofibrosis 3Sanofi Reports Positive Topline Results from Pivotal Phase III JAKARTA Study for JAK2 Inhibitor in Myelofibrosis 4Sanofi Reports Positive Topline Results from Pivotal Phase III JAKARTA Study for JAK2 Inhibitor in Myelofibrosis 5Sanofi Reports Positive Topline Results from Pivotal Phase III JAKARTA Study for JAK2 Inhibitor in Myelofibrosis 6AbbVie and Galapagos Extend GLPG0634 Collaboration to Include Crohn's Disease 2AbbVie and Galapagos Extend GLPG0634 Collaboration to Include Crohn's Disease 3AbbVie and Galapagos Extend GLPG0634 Collaboration to Include Crohn's Disease 4AbbVie and Galapagos Extend GLPG0634 Collaboration to Include Crohn's Disease 5AbbVie and Galapagos Extend GLPG0634 Collaboration to Include Crohn's Disease 6
... , NEW YORK , July 20 ... the Susquehanna International Group of Companies (SIG), announced today that ... Senior Analyst covering the Specialty Pharmaceuticals sector. Mr. Nachman, whose ... Labs , King Pharmaceuticals, Shire Pharmaceuticals and Warner Chilcott ...
... July 20 Medical Device Consultants, Inc. ... (CRO) serving the medical device and diagnostics industry, today ... Services Ltd (CDSS), a clinical services and CRO based ... clients access to the best of both organizations, core ...
Cached Medicine Technology:Susquehanna Financial Group Hires Gary Nachman as Senior Analyst to Cover the Specialty Pharmaceuticals Sector 2Susquehanna Financial Group Hires Gary Nachman as Senior Analyst to Cover the Specialty Pharmaceuticals Sector 3Medical Device Consultants, Inc. and Clinical Development & Support Services Ltd Announce Strategic Partnership 2Medical Device Consultants, Inc. and Clinical Development & Support Services Ltd Announce Strategic Partnership 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: