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Reassuring findings for mothers who have influenza vaccine while pregnant
Date:9/23/2013

pregnancy were no more likely to experience miscarriage, have a baby born with a birth defect or have a baby born smaller than normal compared with those who did not receive a vaccination. Although vaccinated women were more likely to have their babies before term, on average these infants were delivered three days earlier than those born to unvaccinated women.

The VAMPSS team from Boston University's Slone Epidemiology Center interviewed 4,191 mothers from four regional centers in the United States, who had either delivered a baby with one of 41 specific birth defects or delivered a normal infant. They compared the use of influenza vaccine in the two groups during the 2009-2011 seasons. The team also compared the risk of preterm delivery in vaccinated versus unvaccinated women. Overall, no significant evidence of an increased risk of any specific birth defects was noted. While the team did observe a slight increase in preterm delivery rates among pregnant women who received the H1N1 vaccine specifically during the 2009-2010 season, vaccinated women overall only delivered an average of two days earlier compared to the unvaccinated group. For those vaccinated during 2010-2011, the situation was reversed, and vaccinated women were less likely to deliver a preterm baby.

"We found no meaningful evidence of an increase in risk for many specific major birth defects if a woman received the flu shot early in pregnancy," said Carol Louik, ScD, lead investigator of the Boston University team. "A concern about the risk of specific birth defects was a critical question that has not been considered very much until now, and our data are reassuring."


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Contact: Nicole Chavez
ncchavez@ucsd.edu
858-246-1745
University of California - San Diego
Source:Eurekalert

Page: 1 2

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