Navigation Links
Rearrangements of multifunctional genes cause cancer in children and young people
Date:3/10/2009

A doctoral thesis presented at the Sahlgrenska Academy, University of Gothenburg, Sweden, shows that three genes that lie behind a number of malignant tumour diseases are normally involved in several fundamental processes in the cell. This may be the reason that the tumours arise early in life and principally affect children and young people.

A family of genes known as the "FET" genes has been investigated in the work presented in the thesis. This family contains three genes that are found in modified forms in several malignant soft-tissue tumours and several forms of leukaemia. The FET genes are found in these tumours in the form of what are known as "fusion genes" in which parts of two different genes have merged to form one gene. Fusion genes are translated into abnormal fusion proteins, which can in certain cases transform normal cells to cancer cells.

The human body consists of many different types of specialised cell types such as nerve cells, fat cells and intestinal cells. These are formed when stem cells multiply and mature gradually along different developmental pathways. Cancer may arise if something goes wrong in this process. The study has shown that the activities of the genes in the FET family fall as the cells mature, and scientists therefore believe that these genes play a role during the early stages of cell maturation, when the cells are not far from the stem cell stage. The normal maturation pathway of a cell becomes blocked when fusion genes that contain FET genes arise. The result is a cancer cell with properties similar to those of stem cells, and such a cell can multiply in an uncontrolled manner.

"We found that the FET genes are also involved in the response of the cell to external and internal stress, and when cells spread. Alterations of such processes are common in cancer cells", says Mattias Andersson.

It normally requires damage to several different genes before cancer cells develop, and this usuall
'/>"/>

Contact: Ulrika Lundin
ulrika.lundin@sahlgrenska.gu.se
46-707-758-851
University of Gothenburg
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Z Trim Multifunctional Fiber Lightens the Menu Labeling Legislation Issue at Mid-Atlantic Food Expo, September 17 & 18
2. CFO of Genesis Pharmaceuticals Gives Live Interview on Bloomberg TV Asia
3. Cardiogenesis Corporation to Report 2008 Fourth Quarter and Year-End Results on March 31st
4. Study sheds light on angiogenesis inhibitors, points to limitations, solutions
5. Thermogenesis Technology Products Surpass Processing of More Than One Million Units of Cord Blood Stem Cells at 10-Year Milestone
6. Genes May Help Drive Rotator Cuff Injury
7. Genes That Control Bodys Salt Levels Are Identified
8. Empathy Might Be in the Genes
9. Genes Help Cancer-Linked Viruses Elude Immune System
10. 2 Genes Implicated in Autism
11. Genesis Successfully Defends Multi-Million Dollar Arbitration Filed by CRG and CRGP; Related Parties Withdraw Remaining Demands for Arbitration Against Genesis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... Pentec Health, Inc. number fourteen on the ... for 2014. The awards program, created in 2000, is ... in the country. The program is a public/private partnership ... and Economic Development, the Pennsylvania State Council of the ... Business Journal. , Charlie Wilson, Vice President ...
(Date:12/25/2014)... 26, 2014 The click ... beauty, strength and durability. Today, the business announces ... is valid until Jan. 30, 2015. , Click ... traditional hardwood. BambooFlooringChina.com is a well-known brand in ... worldwide to find a reliable bamboo flooring supplier. ...
(Date:12/25/2014)... the popular online supplier of wedding dresses and special occasion ... black one-shoulder cocktail dresses . In addition, all these elegant ... prices, up to 70% off. , The development ... You know, we have thousands of frequent callers in the ... can visit our website for more details. The current special ...
(Date:12/25/2014)... California (PRWEB) December 25, 2014 Helen ... home in Woodland Hills, California after an 8 year ... away on Christmas Eve evening in her home in ... aggressive metastatic breast cancer. , As ... over forty years, she pioneered and championed many of ...
(Date:12/25/2014)... Dec. 25, 2014 (HealthDay News) -- Overeating is common during ... eat in moderation, an expert says. "Don,t arrive at ... calories if you know you,ll be attending a party, but ... Ashbey-Pejoves, lead dietitian at Northern Westchester Hospital in Mount Kisco, ... to eat healthy during the day and even to have ...
Breaking Medicine News(10 mins):Health News:Pentec Health Ranks Fourteenth on The Best Places to Work in PA for 2014 2Health News:Pentec Health Ranks Fourteenth on The Best Places to Work in PA for 2014 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:iFitDress.com: Black One-Shoulder Cocktail Dresses for 2015 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 4
... , ( ) , , , ... N.J., Aug. 6 Smart Balance, Inc. (Nasdaq: SMBL ) today announced its ... of $58.2 million, an increase of 21.2% versus year ago, and earnings per share of ... The second quarter net sales increase versus 2008 was due to a 13% ...
... Lifestyle changes up the odds for Cubans, Puerto Ricans, Mexicans, ... Hispanics who move to the United States, the good life ... their risk for cancer by 40 percent. , Living the ... University of Miami Miller School of Medicine. , Of three ...
... , NASHVILLE, Tenn. and GLEN ... find that 76 percent of surveyed pharmacy directors say ... will have only one preferred biologic for all immune ... ulcerative colitis. According to the new Formulary Forum report ...
... , , REDWOOD CITY, ... ) today announced that Kim Popovits, Genomic Health,s Chief Executive Officer, ... in Boston, on Thursday, August 13 at 1:30 p.m. ET. , ... webcast of the presentation, visit the Investor Relations section of Genomic ...
... , , HOUSTON, ... first patient in a Phase I/II clinical trial of BP-GMAX-CD1, a ... cancer. The disease-specific trial is being conducted under a Bellicum Investigational ... anticipates reporting initial results of the study in 2010. , ...
... KIBBUTZ SHAMIR, Israel, Aug. 6 Shamir Optical ... issue its second quarter of 2009 earnings results on Thursday, August 13(th), ... 11:00 A.M. EDT that morning. , , The ... live, please go to www.kcsa.com approximately five minutes ...
Cached Medicine News:Health News:Smart Balance Announces 2009 Second Quarter Results 2Health News:Smart Balance Announces 2009 Second Quarter Results 3Health News:Smart Balance Announces 2009 Second Quarter Results 4Health News:Smart Balance Announces 2009 Second Quarter Results 5Health News:Smart Balance Announces 2009 Second Quarter Results 6Health News:Smart Balance Announces 2009 Second Quarter Results 7Health News:Smart Balance Announces 2009 Second Quarter Results 8Health News:Smart Balance Announces 2009 Second Quarter Results 9Health News:Smart Balance Announces 2009 Second Quarter Results 10Health News:Living in U.S. May Raise Hispanics' Cancer Risk 2Health News:Living in U.S. May Raise Hispanics' Cancer Risk 3Health News:U.S. Payers Intend to Limit Preferred Coverage to Only One Immune Biologic 2Health News:U.S. Payers Intend to Limit Preferred Coverage to Only One Immune Biologic 3Health News:Bellicum Pharmaceuticals Announces Initiation of Phase I/II Clinical Trial of Novel Vaccine for Patients With Advanced Prostate Cancer 2Health News:Bellicum Pharmaceuticals Announces Initiation of Phase I/II Clinical Trial of Novel Vaccine for Patients With Advanced Prostate Cancer 3Health News:Shamir Optical Industry Ltd. to Host Conference Call Announcing Second Quarter of 2009 Earnings Results 2
(Date:12/24/2014)... , Dec. 24, 2014  Commonwealth Cornerstone Group (CCG) ... Tax Credits transaction on Tuesday to help fund the expansion ... (PHN) in Sharon . ... Pennsylvania . It is the largest employer ... more than 150 people on staff. Currently, PHN ...
(Date:12/24/2014)... , Dec. 24, 2014 Kinex Pharmaceuticals ... with KX2-361 at Roswell Park Cancer Institute. ... molecule drug that has shown potent inhibitory activity against ... those that are resistant to Temozolomide (T98G), the most ... In a well-established brain tumor mouse model, KX2-361 consistently ...
(Date:12/24/2014)... BEIJING , Dec. 24, 2014  The International Trade ... by ResMed (RMD) against BMC Medical. In a notice issued ... and found that ResMed,s patent on its humidifier was invalid. ... decision a "monumental win". "We are very excited with the ... the position that we have taken since the very beginning ...
Breaking Medicine Technology:Commonwealth Cornerstone Group Announces $8 Million in Tax Credits to Expand and Consolidate Healthcare Services in Sharon 2Commonwealth Cornerstone Group Announces $8 Million in Tax Credits to Expand and Consolidate Healthcare Services in Sharon 3Kinex Pharmaceuticals Announces First Patient Dosed with KX2-361 in a Phase 1 Clinical Study 2Kinex Pharmaceuticals Announces First Patient Dosed with KX2-361 in a Phase 1 Clinical Study 3ITC Final Decision Goes Against ResMed (RMD) Monumental Win for 3B/BMC 2
... 10 A recent national survey of 505 pharmacists found ... for a patient to seek treatment early to help shorten ... percent of pharmacists say most patients should purchase over-the-counter (OTC) ... while only 26 percent of their patients take this proactive ...
... Nov. 10 Reportlinker.com announces that a ... its catalogue. , Injectable Drug ... , http://www.reportlinker.com/p0158352/Injectable-Drug-Delivery-Market-Impact-and-Industry-Trends.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=prnewswire ... grows, companies are increasingly looking towards the ...
Cached Medicine Technology:Pharmacists Report Patients do not Treat Cold and Flu Symptoms Early Enough, New Survey Shows 2Pharmacists Report Patients do not Treat Cold and Flu Symptoms Early Enough, New Survey Shows 3Reportlinker Adds Injectable Drug Delivery: Market Impact and Industry Trends 2Reportlinker Adds Injectable Drug Delivery: Market Impact and Industry Trends 3Reportlinker Adds Injectable Drug Delivery: Market Impact and Industry Trends 4Reportlinker Adds Injectable Drug Delivery: Market Impact and Industry Trends 5Reportlinker Adds Injectable Drug Delivery: Market Impact and Industry Trends 6
The FastPack system is a state of the art, lab quality immunoassay system designed for rapid results. The FastPack system delivers lab-quality sensitivity at a fraction of the cost of laboratory....
... The Vitros ECi brings true ... to immunodiagnostic testing. Highly sensitive assays ... oncology and bone metabolism testing are ... under development. The Vitros ECi can ...
... Vitros 250 is a flexible ... in multiple environments small ... clinics and satellite locations. The ... dilution, and can be automated ...
... In an effort to improve on ... hormones, toxicology, abused drugs, and immunosuppressants ... 1991 which incorporates random access capabilities. ... has undergone several important changes in ...
Medicine Products: