Navigation Links
Rearrangements of multifunctional genes cause cancer in children and young people
Date:3/10/2009

A doctoral thesis presented at the Sahlgrenska Academy, University of Gothenburg, Sweden, shows that three genes that lie behind a number of malignant tumour diseases are normally involved in several fundamental processes in the cell. This may be the reason that the tumours arise early in life and principally affect children and young people.

A family of genes known as the "FET" genes has been investigated in the work presented in the thesis. This family contains three genes that are found in modified forms in several malignant soft-tissue tumours and several forms of leukaemia. The FET genes are found in these tumours in the form of what are known as "fusion genes" in which parts of two different genes have merged to form one gene. Fusion genes are translated into abnormal fusion proteins, which can in certain cases transform normal cells to cancer cells.

The human body consists of many different types of specialised cell types such as nerve cells, fat cells and intestinal cells. These are formed when stem cells multiply and mature gradually along different developmental pathways. Cancer may arise if something goes wrong in this process. The study has shown that the activities of the genes in the FET family fall as the cells mature, and scientists therefore believe that these genes play a role during the early stages of cell maturation, when the cells are not far from the stem cell stage. The normal maturation pathway of a cell becomes blocked when fusion genes that contain FET genes arise. The result is a cancer cell with properties similar to those of stem cells, and such a cell can multiply in an uncontrolled manner.

"We found that the FET genes are also involved in the response of the cell to external and internal stress, and when cells spread. Alterations of such processes are common in cancer cells", says Mattias Andersson.

It normally requires damage to several different genes before cancer cells develop, and this usuall
'/>"/>

Contact: Ulrika Lundin
ulrika.lundin@sahlgrenska.gu.se
46-707-758-851
University of Gothenburg
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Z Trim Multifunctional Fiber Lightens the Menu Labeling Legislation Issue at Mid-Atlantic Food Expo, September 17 & 18
2. CFO of Genesis Pharmaceuticals Gives Live Interview on Bloomberg TV Asia
3. Cardiogenesis Corporation to Report 2008 Fourth Quarter and Year-End Results on March 31st
4. Study sheds light on angiogenesis inhibitors, points to limitations, solutions
5. Thermogenesis Technology Products Surpass Processing of More Than One Million Units of Cord Blood Stem Cells at 10-Year Milestone
6. Genes May Help Drive Rotator Cuff Injury
7. Genes That Control Bodys Salt Levels Are Identified
8. Empathy Might Be in the Genes
9. Genes Help Cancer-Linked Viruses Elude Immune System
10. 2 Genes Implicated in Autism
11. Genesis Successfully Defends Multi-Million Dollar Arbitration Filed by CRG and CRGP; Related Parties Withdraw Remaining Demands for Arbitration Against Genesis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... Phoenix, AZ (PRWEB) July 25, 2014 ... firm offering discount attorney’s fees with regard to ... Hastings provide a wide range of legal services ... of the negligence of another individual or corporation. Free ... of determining the validity of a potential personal ...
(Date:7/25/2014)... for lymphoma may lower men,s fertility, new research indicates. ... cancers of the body,s white blood cells, often affect ... For men, treatment for these cancers can harm or ... within two years of treatment, the researchers cautioned that ... significant side effect before treatment begins. "While many ...
(Date:7/25/2014)... 2014 Parkulture is proud ... and parkour instructor, Jared “JJ” Woods, will be competing ... American Ninja Warrior. The show will premiere on local ... will rerun on the new Esquire Network on Tuesday, ... resident, has been balancing careers as a professional stuntman ...
(Date:7/25/2014)... The Rottenstein Law Group LLP, ... 25 years of experience advocating for plaintiffs with ... announces the launch of its new website, ... believe they have been harmed by the prescription ... information about the severe adverse side effects allegedly ...
(Date:7/25/2014)... Twins, genes may play a greater role in language ... Researchers found more evidence that language traits, ... largely inherited. The study involving 473 sets of ... of language performance for twins than single-born children) was ... finding disputes hypotheses that attribute delays in early language ...
Breaking Medicine News(10 mins):Health News:Hastings and Hastings Announces Complimentary Consultation Services 2Health News:Hastings and Hastings Announces Complimentary Consultation Services 3Health News:Lymphoma Treatment May Harm, Halt Men's Sperm Production 2Health News:Jared “JJ” Woods Prepares for American Ninja Warrior City Finals 2Health News:Jared “JJ” Woods Prepares for American Ninja Warrior City Finals 3Health News:Rottenstein Law Group LLP Announces Launch of Xarelto Injury Website 2Health News:Genes May Be Key to Language Delay in Kids 2
... is very rare, affecting approximately one in every 100,000 ... i.e. they are born with empty eye sockets. This ... in the normal way in the first 28 days ... fitted with prosthetic eyes to allow normal facial// development. ...
... which occurs when the heart becomes so enlarged that it ... affects 35 in every 100,000 people. Researchers in the United ... journal Science that a defect in the gene phospholamban may ... the flow of calcium through the heart, enabling it to ...
... using a new imaging technique based on Magnetic Resonance ... now, MRI was used to show how Alzheimer's disease ... for memory and learning. And post-mortem studies revealed how ... the first time a three-dimensional time lapse video of ...
... by scientists at the Johns Hopkins School of Public Health ... have called for urgent research into the impact of soya ... chemical in soya can damage the male reproductive organs. Though ... effect on humans, its effects on rats were so severe ...
... published in the February issue of the British Medical Journal ... more at risk of heart disease later in life than ... live infant in Scotland during the years 1981-85, were identified ... miscarriage or repeated miscarriages. Then, during 1981 to 1999, the ...
... blood has been believed to be the most ... heart disease is associated with increased levels of ... LDL(Low-Density Lipoprotein)or 'bad' cholesterol and HDL(High-Density Lipoprotein) or ... researchers in Canada and Sweden are now putting ...
Cached Medicine News:Health News:Miscarriage during pregnancy and heart disease linked 2
(Date:7/24/2014)... , July 24, 2014 IGI Laboratories, ... based specialty generic pharmaceutical company, today announced ... its Board of Directors.  Mr. Finio has accepted a ... under the terms of his acceptance of his new ... his role as Director for IGI Laboratories, Inc.  The ...
(Date:7/24/2014)... Many new dentists who are opening their own ... their practice will be a success. DentalDisposables.net is here to ... the most can make all the difference. Dentistry is a ... that purchasing discount dental supplies can make the ... successful dentists across the United States ...
(Date:7/24/2014)... 24, 2014  Perrigo Company (NYSE: PRGO ... AB therapeutic equivalent rating from the U.S. Food and ... Application (NDA) for testosterone gel 1.0%. FDA concluded that ... 1% and can be substituted with the full expectation ... safety profile as AndroGel 1% when used under the ...
Breaking Medicine Technology:IGI Laboratories, Inc. Announces Change To Its Board Of Directors 2Dental Supplies Online is Key to Dental Success...Really! 2Perrigo Confirms AB Therapeutic Equivalent Rating From The FDA For Its Testosterone Gel 1.0% 2Perrigo Confirms AB Therapeutic Equivalent Rating From The FDA For Its Testosterone Gel 1.0% 3
... The U.S. Food and Drug Administration today approved the ... to treat certain infections in people ages 18 and ... Levofloxacin is used to treat mild, moderate, or ... and prostate caused by specific germs. It also is ...
... The Consumer Healthcare Products Association (CHPA) released the ... Perry signing into law legislation that implements a ... common cold and allergy medicines containing pseudoephedrine (PSE), ... "We applaud the work of Texas ...
Cached Medicine Technology:FDA Approves First Generic Versions of the Antibiotic Levofloxacin to Treat Certain Infections 2
... designed for low to medium throughput reading of ... from one to three racks and reads in ... are exported via text files and a list ... integration with other programs. System includes a USB ...
... steel work surface. Pneumatic ... to protect operator, as ... equipment from the workstation. ... for multiple vibration-free work ...
... top with powder-coated steel legs. ... Available in hundreds of sizes ... drawers, light fixtures and ionizing ... in custom building to meet ...
Round, height-adjustable, steel laboratory stools with small footprint for small spaces • Choose options like different height-adjustment mechanism or paint finish. • your choice of color...
Medicine Products: