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Ready for relapse: Molecule helps breast cancer cells to survive in the bone marrow
Date:7/6/2009

to a key cell death-inducing signal that was abundantly expressed in bone metastasis tissue. These results demonstrate that Src hyperactivity provides breast cancer cells with a superior ability to survive in the bone marrow.

"The link between Src-dependent signaling and metastatic cell survival provides mechanistic insights into metastasis latency, and suggests strategies to hasten the attrition of disseminated breast cancer cells," concludes Dr. Massague. "Recently, a number of pharmacological Src inhibitors have been developed that may be worthy of consideration in this respect."


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Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Source:Eurekalert

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