Navigation Links
Ready for relapse: Molecule helps breast cancer cells to survive in the bone marrow

Patients who survive an initial diagnosis of breast cancer often succumb to the disease years later when the cancer shows up in a different part of the body. Now, scientists have identified key signals that support the long term survival of breast cancer cells after they have spread to the bone marrow. The research, published by Cell Press in the July issue of the journal Cancer Cell, may lead to development of treatment strategies that decrease the likelihood of breast cancer recurrence in the bone and other organs.

Metastasis, the ability of cancer cells to spread from the initial site of origin to other parts of the body, occurs frequently in breast cancer. Although it is clear that the majority of late-onset relapses after breast cancer arise in the bone, the mechanisms that contribute to cancer cell survival in the bone marrow environment are unknown.

"We sought to identify signaling pathways that support the survival of metastasized breast cancer cells and thereby extend the period during which metastasis may emerge after the diagnosis and removal of a breast tumor," explains senior study author Dr. Joan Massague from the Cancer Biology and Genetics Programs at Memorial Sloan-Kettering Cancer Center and the Howard Hughes Medical Institute.

Dr. Massague and colleagues used a sophisticated gene profiling technique link specific signaling pathways with late-onset relapse after breast cancer. In an investigation of samples from over 600 breast tumors, the researchers discovered that activity of a cancer-related enzyme called Src was associated with late-onset bone metastasis. Interestingly, this link was independent of breast cancer subtype and was selective and specific for cell survival in the bone marrow.

The researchers went on to identify Src-regulated signaling molecules that were expressed in the bone marrow and promoted cell survival. Further, Src increased the resistance of metastasized breast cancer cells to a key cell death-inducing signal that was abundantly expressed in bone metastasis tissue. These results demonstrate that Src hyperactivity provides breast cancer cells with a superior ability to survive in the bone marrow.

"The link between Src-dependent signaling and metastatic cell survival provides mechanistic insights into metastasis latency, and suggests strategies to hasten the attrition of disseminated breast cancer cells," concludes Dr. Massague. "Recently, a number of pharmacological Src inhibitors have been developed that may be worthy of consideration in this respect."


Contact: Cathleen Genova
Cell Press

Related medicine news :

1. Looking to Shape up for Summer? The Solution May be the Steps Youre Already Taking
2. Video: Get Swimsuit Ready Faster and Easier Than Ever Before With New LifeSculpt Laser Treatment
3. Public Ready for Changes to Health-Care System But Unclear About Necessary Trade-Offs, Citizen Forums Suggest
4. Red Cross, CDC Ready Country for Emergency Threats
5. First Batch of Swine Flu Vaccine Already Here: Company
6. Fast pandemic detection tool ready to fight flu
7. Bear Naked Launches Its First Ready-to-Eat Cereal
8. Swine Flu Vaccine Wont Be Ready Until October: CDC
9. SMOS ready to ship to launch site
10. County and City Leaders Coordinate to Just Be Ready
11. Ready or Not - Flu Pandemic Has Arrived
Post Your Comments:
(Date:6/25/2016)... ... ... First Choice Emergency Room , the largest network of independent freestanding ... of its new Mesquite-Samuell Farm facility. , “We are pleased to announce Dr. ... James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , Dr. ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary of ... award to iHire in recognition of their exemplary accomplishments in worksite health promotion. , ... Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Those who have ... these feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, as ... Michigan, has released tools for healthy coping following a traumatic event. , Trauma sufferers ...
(Date:6/24/2016)... Texas (PRWEB) , ... June 24, 2016 , ... ... International Conference and Scientific Sessions in Dallas that it will receive two significant ... of the grants came as PHA marked its 25th anniversary by recognizing patients, ...
(Date:6/24/2016)... ... , ... Comfort Keepers® of San Diego, CA is excited to announce they ... to drive cancer patients to and from their cancer treatments. Comfort Keepers provides ... life and ongoing independence. Getting to and from medical treatments is one of ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 Research and ... Market for Companion Diagnostic Tests" report to their offering. ... for Companion Diagnostics The World Market for ... personalized medicine diagnostics. Market analysis in the report includes the ... Market (In Vitro Diagnostic Kits) by Region (N. America, EU, ...
(Date:6/24/2016)... Tenn. , June 24, 2016  Arkis ... providing less invasive and more durable cerebrospinal fluid ... in funding.  The Series-A funding is led by ... Lighthouse Fund, and other private investors.  Arkis, new ... neurosurgical instrumentation and the market release of its ...
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... the "Pharmaceutical Excipients Market by Type (Organic Chemical ... Preservative), Formulation (Oral, Topical, Coating, Parenteral) - Global Forecast ... The global pharmaceutical excipients ... 2021 at a CAGR of 6.1% in the forecast ...
Breaking Medicine Technology: