Navigation Links
Ready for relapse: Molecule helps breast cancer cells to survive in the bone marrow
Date:7/6/2009

Patients who survive an initial diagnosis of breast cancer often succumb to the disease years later when the cancer shows up in a different part of the body. Now, scientists have identified key signals that support the long term survival of breast cancer cells after they have spread to the bone marrow. The research, published by Cell Press in the July issue of the journal Cancer Cell, may lead to development of treatment strategies that decrease the likelihood of breast cancer recurrence in the bone and other organs.

Metastasis, the ability of cancer cells to spread from the initial site of origin to other parts of the body, occurs frequently in breast cancer. Although it is clear that the majority of late-onset relapses after breast cancer arise in the bone, the mechanisms that contribute to cancer cell survival in the bone marrow environment are unknown.

"We sought to identify signaling pathways that support the survival of metastasized breast cancer cells and thereby extend the period during which metastasis may emerge after the diagnosis and removal of a breast tumor," explains senior study author Dr. Joan Massague from the Cancer Biology and Genetics Programs at Memorial Sloan-Kettering Cancer Center and the Howard Hughes Medical Institute.

Dr. Massague and colleagues used a sophisticated gene profiling technique link specific signaling pathways with late-onset relapse after breast cancer. In an investigation of samples from over 600 breast tumors, the researchers discovered that activity of a cancer-related enzyme called Src was associated with late-onset bone metastasis. Interestingly, this link was independent of breast cancer subtype and was selective and specific for cell survival in the bone marrow.

The researchers went on to identify Src-regulated signaling molecules that were expressed in the bone marrow and promoted cell survival. Further, Src increased the resistance of metastasized breast cancer cells
'/>"/>

Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Looking to Shape up for Summer? The Solution May be the Steps Youre Already Taking
2. Video: Get Swimsuit Ready Faster and Easier Than Ever Before With New LifeSculpt Laser Treatment
3. Public Ready for Changes to Health-Care System But Unclear About Necessary Trade-Offs, Citizen Forums Suggest
4. Red Cross, CDC Ready Country for Emergency Threats
5. First Batch of Swine Flu Vaccine Already Here: Company
6. Fast pandemic detection tool ready to fight flu
7. Bear Naked Launches Its First Ready-to-Eat Cereal
8. Swine Flu Vaccine Wont Be Ready Until October: CDC
9. SMOS ready to ship to launch site
10. County and City Leaders Coordinate to Just Be Ready
11. Ready or Not - Flu Pandemic Has Arrived
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2015)... WI (PRWEB) June 03, 2015 The ... regulated industries such as government, finance and healthcare. However, ... that wants reliable access control to enhance the security ... keyboard requires the secondary authentication of a Smart Card ... addition to the smart-chipset card reader, the keyboard supports ...
(Date:6/2/2015)... 2015 MEDIA ADVISORY, June 2, ... , Email: ewallace(at)mentalhealthamerica(dot)net , Breaking News: Congressman Tim ... Legislation at MHA Annual Conference Thursday , Who: ... to address the Mental Health America Annual Conference ... version of the Helping Families in Mental Health ...
(Date:6/2/2015)... 02, 2015 Highly qualified dental care specialists ... to drive prolific change in the dental tourism industry in ... Dental Clinic offers a full range of superior dental ... for dental tourism. , Partnered with a top medical ... to advancing dentistry and has earned a reputation as an ...
(Date:6/2/2015)... June 02, 2015 UCLA Health and ... intent to partner and expand urgent care services in ... approval by the University of California Board of Regents ... will allow UCLA Health to purchase a minority share ... Hills, Calabasas, Newbury Park and Northridge and creates opportunity ...
(Date:6/2/2015)... Bitscape Infotech today announced it has ... Small and Midsized Cloud Solutions Award. The company was ... for demonstrating excellence in innovation and implementation of customer ... as no surprise to us as we feel our ... worldwide level by Microsoft. We will continue to lead ...
Breaking Medicine News(10 mins):Health News:Introducing the New CHERRY JK-A0100EU Keyboard with Integrated Smart Card Reader for Access Control Security 2Health News:Congressman Tim Murphy to Unveil Details of New Mental Health Legislation at MHA Annual Conference Thursday 2Health News:Team Dental Clinic Unveils Plan to Drive Change in the Dental Tourism Industry 2Health News:Team Dental Clinic Unveils Plan to Drive Change in the Dental Tourism Industry 3Health News:UCLA Health Partners With Exer - More Than Urgent Care 2Health News:Bitscape Infotech recognized as finalist for 2015 Microsoft Worldwide small & midsized cloud solutions award. 2Health News:Bitscape Infotech recognized as finalist for 2015 Microsoft Worldwide small & midsized cloud solutions award. 3
... high efficiency http://www.nmbtc.com [brushless dc motors] ideally suited ... , ... Chatsworth, CA (PRWEB) ... line of high efficiency http://www.nmbtc.com [brushless dc motors] ...
... International fire chiefs collaborate to save lives at the ... Global Fire ... In a unique six-day,conference, fire service leaders from around ... share best practices, sharpen their,management and leadership skills and ...
... treatment often not started among middle-aged men, study finds , , ... don,t start treatment of middle-aged men with high blood pressure ... in the study happened to be black, but the same ... Ravenell, who was expected to report the findings Friday at ...
... , ... Jacksonville, FL (Vocus) September 19, 2008 -- ... and the Florida Bioethics Network, will hold a www.miami.edu/ethics/fbn ... conference will be held at the Prime Osborne Convention Center, 1000 ...
... conduct problems, study says , , THURSDAY, Sept. 18 (HealthDay News) ... to have sexual intercourse in early adolescence and to have ... says. , The study included 2,596 Canadian ... , "Young girls who live in disadvantaged neighborhoods are more ...
... Denver-area Clinic Provides the Latest in Non-Invasive Aesthetic Treatments ... ... 2008 -- American Laser Centers, http://www.americanlaser.com [American Laser ... removal and other noninvasive aesthetic services in the U.S., has ...
Cached Medicine News:Health News:New High Performance Brushless dc Motors From NMB 2Health News:Underwriters Laboratories to Host Global Leadership Conference on Fire and Life Safety 2Health News:Underwriters Laboratories to Host Global Leadership Conference on Fire and Life Safety 3Health News:Many Doctors Don't Know Blood Pressure Guidelines 2Health News:Pediatrics Bioethics Conference to Be Held in Jacksonville, Florida, October 10-11, 2008 2Health News:Girls From Poorer Areas More Likely to Have Sex Earlier 2Health News:Popular Denver Divas Host to Manage the New American Laser Centers Clinic in Arvada 2
(Date:6/2/2015)... June 2, 2015  One hundred percent of Adventist ... Nurse Anesthesia (MSNA) graduates of April 2015 have passed ... The graduating class was composed of 20 students who ... The NCE is required of every graduate in ... graduates of the MSNA program are eligible for state ...
(Date:6/2/2015)... San MediTech, the industry leader in ... for diabetics, announced its plan to attend the American ... Boston on June 5 th to ... Monitoring System (DGMS). The company plans to show industry ... technologies and advancements made by Chinese medical device companies. ...
(Date:6/2/2015)... 2015  CytRx Corporation (NASDAQ: CYTR ), a ... announced that it has reached an agreement to settle ... Delaware Court of Chancery, which names as ... directors and officers, and names the Company as a ... re CytRx Corp. Stockholder Derivative Litigation , C.A. No. ...
Breaking Medicine Technology:ADU's Master of Science in Nurse Anesthesia April 2015 Graduates Earn 100 Percent First Time Pass Rate on National Certification Examination 2San MediTech Showcases Smart Glucose Management Cloud Database at 75th ADA 2San MediTech Showcases Smart Glucose Management Cloud Database at 75th ADA 3San MediTech Showcases Smart Glucose Management Cloud Database at 75th ADA 4CytRx Announces Settlement of Stockholder Derivative Lawsuit in Delaware 2CytRx Announces Settlement of Stockholder Derivative Lawsuit in Delaware 3CytRx Announces Settlement of Stockholder Derivative Lawsuit in Delaware 4
... Calif., July 15, 2011 Amgen (NASDAQ: ... States (U.S.) District Court in Pennsylvania has entered ... Pharmaceutical Industries Ltd. and Teva Pharmaceuticals USA prohibiting ... G-CSF (granulocyte colony-stimulating factor) and methods for its ...
... EDISON, N.J., July 15, 2011 Crestor ... designed to lower "bad cholesterol". Both drugs are classified ... inhibiting HMG-CoA reductase. This group of drugs has had ... to Crestor and Zocor, touted as a "super statin" ...
Cached Medicine Technology:Amgen Resolves G-CSF Patent Litigation With Teva 2Crestor and Zocor Drugs Linked to Muscle Degeneration, Rhabdomyolysis 2
Ambion's barrier tips prevent cross-contamination of samples by means of an aerosol filter. They are RNase- and DNase-free and are ideal for handling RNA, PCR applications, and for working with radio...
Ambion's barrier tips prevent cross-contamination of samples by means of an aerosol filter. They are RNase- and DNase-free and are ideal for handling RNA, PCR applications, and for working with radio...
10 L, Bulk Recommended for 5 and 10 L pipettes. Ideal for pipetting into long, narrow tubes or deep well plates....
This ultra micro tip for the Eppendorf and Nichiryo/BenchMate 0.5-10 L pipettors is perfect for working with low volume....
Medicine Products: