Navigation Links
Reactions to HIV drug have autoimmune cause, reports AIDS journal
Date:5/22/2012

Philadelphia, Pa. (May 22, 2012) Potentially severe hypersensitivity reactions to the anti-HIV drug abacavir occur through an autoimmune mechanism, resulting from the creation of drug-induced immunogens that are attacked by the body's immune system, according to a study published online by the journal AIDS, official journal of the International AIDS Society. AIDS is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

The study is the first to explain how hypersensitivity reactions to abacavir develop in genetically predisposed patientsand suggests that similar autoimmune mechanisms might account for other types of drug reactions related to variants in the human leukocyte antigen (HLA) system. The lead author is Dr Michael A. Norcross of the U.S. Food and Drug Administration's Center for Drug Evaluation and Research. The publish-ahead-of-print article is currently available on the AIDS journal homepage and will be available in the July 17, 2012 print edition.

Abacavir Hypersensitivity Results from 'Drug-Induced Autoimmunity'

Dr Norcross and colleagues performed a series of laboratory experiments to examine why some patients develop hypersensitivity reactions to the antiretroviral drug abacavir (Ziagenalso included in combination products such as Epzicom and Trizivir). Developing a few weeks after the start of treatment, the reactions cause a wide range of symptoms including fever, rash, nausea, muscle soreness, and shortness of breath.

The reactions have been linked to a ge
'/>"/>

Contact: Connie Hughes
Connie.Hughes@wolterskluwer.com
646-674-6348
Wolters Kluwer Health
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Delayed Reactions May Outlast Other Concussion Effects
2. Kids Penicillin Allergy May Not Signal Other Drug Reactions
3. Air Fresheners, Scented Candles May Spur Allergic Reactions
4. Researchers engineer a new way to inhibit allergic reactions without side effects
5. Over Half of Adverse Drug Reactions in Hospitals Are Preventable: Study
6. Mayo Clinic wins grant to gauge genetic risk of heart attacks, adverse drug reactions
7. Tainted Cocaine Tied to Severe Skin Reactions
8. Adulterated cocaine causing serious skin reactions
9. Tanning bed exposure can be deadly when complicated by medication reactions
10. RXplore: New Regenstrief tool lets docs instantly track down drug reactions
11. Meat Might Be Behind Many Unidentified Allergic Reactions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/2/2015)... ... 2015 , ... Molecular biologists in New South Wales say a protein linked ... just posted an article on the new research. Click here to read it ... expression in tissue samples from 42 patients with peritoneal mesothelioma and found a direct ...
(Date:8/1/2015)... ... 02, 2015 , ... Back packs can be dangerous? Whaaat?! , Not the ... wreck havoc on a kid's spine. With school starting again, most kids will be ... sure you are aware of how to help them prevent injuries by understanding backpack ...
(Date:8/1/2015)... CA (PRWEB) , ... August 01, 2015 , ... Have you ever wondered what “Karma” ... when you hear the word “Karma.” , Vedic tradition, which gave birth to Hinduism, ... is one of the central concepts of this tradition. According to the wisdom of this ...
(Date:8/1/2015)... ... , ... Calvary Hospital today announced that it is embarking on a yearlong ... to bring this Torah – dating from 1880 – back to kosher status, so ... , Scroll No. 515, from the town of Taus-Domazlice, is on permanent loan to ...
(Date:8/1/2015)... ... August 01, 2015 , ... Brig and Lita Hart, icons of ... unification of their Healthy Home mission with the HOPE Movement of EvolvHealth. In what ... of both companies have agreed to join their missions of purpose together to change ...
Breaking Medicine News(10 mins):Health News:Scientists Link Protein Marker with Mesothelioma Prognosis in New Study, According to Surviving Mesothelioma 2Health News:Local AlignLife Doctor Donates Time to Check Back Packs 2Health News:Nithyananda Yoga Foundation to Conduct Global Webinar on Karma at No Charge on August 1st 2Health News:Calvary Hospital Announces Plans to Restore Historic Torah 2Health News:Calvary Hospital Announces Plans to Restore Historic Torah 3Health News:Looking for HOPE? Healthy Home Has Evolv’d 2Health News:Looking for HOPE? Healthy Home Has Evolv’d 3
... procedures and techniques discussed at surgeons, conference, ... surgery patients are getting back on their feet ... introduction of tissue graft products, bone anchors, radio,frequency ... invasive treatments and speedier recovery times. More than ...
... TIKVA, Israel, February 20 012,Smile.Communications (Nasdaq: ... fourth quarter results on Tuesday , February 26, ... day, Management will host an interactive,teleconference to discuss ... call one of the following access numbers several ...
... Worst Among Racial Minorities, the Uninsured and,Medicare ... New data revealing,decreasing trends in cancer deaths ... cancer deaths in particular, highlight the remarkable ... lifesaving potential of these,tests is unrealized for ...
... Publications today announced,that several stem cell experts, including ... medicine services (oncology) at Case Western Reserve,University, Wise ... W.M. Keck,Center for Collaborative Neuroscience and a professor ... R. Lyon, M.D., the chief of orthopaedic,surgery at ...
... Accenx Technologies, Inc., a,leading company in electronic medical ... and BayCare Health System of,Clearwater, FL, announced today ... implement its RyTRAK HIE system to exchange clinical ... health care providers to exchange clinical data,seamlessly between ...
... Institute of Standards and Technology (NIST) can detect nuclear ... through a novel microchip. The prototype chip device, developed ... California, may have wide application as a sensitive chemical ... drugs. , As described in Proceedings of the National ...
Cached Medicine News:Health News:Achilles Tendon Surgery Advances Speed Recovery 2Health News:012 Smile.Communication's Fourth Quarter Earnings Release and Conference Call Scheduled for February 26, 2008 2Health News:012 Smile.Communication's Fourth Quarter Earnings Release and Conference Call Scheduled for February 26, 2008 3Health News:U.S. Cancer Deaths Down But Far Too Few Americans Screened for Colon Cancer 2Health News:U.S. Cancer Deaths Down But Far Too Few Americans Screened for Colon Cancer 3Health News:U.S. Cancer Deaths Down But Far Too Few Americans Screened for Colon Cancer 4Health News:Stem Cell Experts and New York Lt. Gov. David Paterson to Participate in 3rd Annual Stem Cell Summit as Keynote Speakers 2Health News:Stem Cell Experts and New York Lt. Gov. David Paterson to Participate in 3rd Annual Stem Cell Summit as Keynote Speakers 3Health News:BayCare Health System Collaborates With Accenx to Provide Reliable Exchange of Information 2Health News:'NMR on a chip' features NIST magnetic mini-sensor 2
(Date:7/31/2015)... , July 31, 2015 Egalet ... integrated specialty pharmaceutical company focused on developing, manufacturing ... closing of its previously announced underwritten public offering ... a public offering price of $11.25 per share. ... included 1,000,000 shares issued upon the exercise in ...
(Date:7/31/2015)... Calif. , July 31, 2015  Xencor, Inc. ... engineered monoclonal antibodies for the treatment of autoimmune diseases, ... appointment of Yujiro S. Hata to its ... experience in business and corporate development is a tremendous ... Ph.D., president and chief executive officer of Xencor. "Xencor ...
(Date:7/30/2015)... IRVINE, Calif. , July 30, 2015 Edwards ... the science of heart valves and hemodynamic monitoring, today announced ... company,s Board of Directors. "Bob is an ardent ... been a true privilege to have him on Edwards, board ... A. Mussallem , Edwards, chairman and CEO.  "Bob has provided ...
Breaking Medicine Technology:Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 2Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 3Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 4Xencor Appoints Yujiro S. Hata to Board of Directors 2Xencor Appoints Yujiro S. Hata to Board of Directors 3
... CO-Oximeter Control (Bayer 800 Series) is ... monitoring the performance of blood gas, ... 270 and 800 series) instrumentation. This ... Bayer 800 Rapidlab Series instruments in ...
Liquichek Blood Gas Plus CO-Oximeter Control (IL Synthesis Series) is a combination control for use in monitoring the performance of blood gas, ion-selective electrode, biosensor and CO-Oximetry anal...
Liquichek Blood Gas Plus E Control is an aqueous product used to monitor the measurement of pH, pCO2, pO2 and electrolytes. Available in four levels....
Liquichek CK/LD Isoenzyme Control features analytes used in cardiac profile testing and protein electrophoresis. Assayed for most methods including instruments, immunoinhibition kits and electrophore...
Medicine Products: