Navigation Links
Reach2HD, a Phase II study in Huntington's disease, launched
Date:6/7/2012

The Huntington Study Group (HSG), under the leadership of Ray Dorsey, M.D. with Johns Hopkins Medical and Diana Rosas, M.D. with Massachusetts General Hospital, is conducting a clinical trial in Huntington's disease (HD) throughout the United States and Australia, "A randomized, double-blind, placebo-controlled, study to assess the safety and tolerability, and efficacy of PBT2 in patients with early to mid-stage Huntington's disease" comparing a 100 mg dose or 250 mg dose versus placebo. The HSG is a not-for-profit group of physicians and other clinical researchers who are experienced in the care of HD patients and dedicated to clinical research of the disease. This trial is sponsored by Prana Biotechnology Limited (Melbourne, Australia) and is being managed by the University of Rochester Medical Center.

Huntington's disease is an inherited neurodegenerative disease which affects over 30,000 people in both the United States and Australia. HD is characterized by brain cell death that usually begins between the ages of 30 to 50, and results in motor, cognitive and behavioral signs and symptoms. While there are medications to help relieve some of the disease symptoms, there is no known treatment to address the cognitive impairment associated with HD.

Research has shown that normally occurring metals in the brain play a significant role in diseases such as Alzheimer's disease and more recently, HD. Researchers at Prana Biotechnology are identifying drugs designed to interrupt interactions between these biological metals and target proteins in the brain, to prevent deterioration of brain cells. One of the chemical compounds, called PBT2, has shown in animal models, and as well as in a small group of patients with Alzheimer's disease, that it may improve cognition. There is some indication in animal models of HD, that the drug may improve motor function and control, increase life span and reduce the amount of brain cell degeneration. Based on the
'/>"/>

Contact: Mark Michaud
mark_michaud@urmc.rochester.edu
585-273-4790
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. ALS patients differ on treatment choices in later phases of disease
2. Study Suggests Vaccine May Help Kids With Brain Cancer
3. Study reveals how cancer drug causes diabetic-like state
4. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
5. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
6. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
7. No Added Cancer Risk From Hip Replacement Materials: Study
8. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
9. Early Study Finds Some Promise for Lung Cancer Vaccine
10. Narcissists Often Ace Job Interviews, Study Finds
11. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... iFitDress.com, one of the most famous dress suppliers in the ... collection. According to the company’s sales manager, all these ... 69% off) at present. Additionally, all the company’s old clients ... frequent caller of your site. I like your products very ... happy. All items are of good quality. I sincerely want ...
(Date:9/16/2014)... HealthDay Reporter TUESDAY, Sept. ... routinely spot human papillomavirus (HPV), which is linked to the ... study shows that testing urine for HPV has good accuracy ... HPV," said lead researcher Dr. Neha Pathak. She is a ... Mary University of London, England. The test could be ...
(Date:9/16/2014)... September 16, 2014 These new programs allow ... years to receive up to $10,000 in a 0% interest ... well as other state and federal programs, are listed on ... paid back until you sell or move out of the ... 0% interest loan. There are no monthly payments paid by ...
(Date:9/16/2014)... A new study found that fractional flow ... true coronary bifurcation lesions yields similar outcomes to ... trial is the first study to compare FFR-guided ... today at the 26th annual Transcatheter Cardiovascular Therapeutics ... Foundation (CRF), TCT is the world,s premier educational ...
(Date:9/16/2014)... September 16, 2014 Programs and policies ... hundreds of billions of dollars in savings for the ... the Commonwealth Fund. To help spur these types of ... to 10 collaborative groups from across the country to ... http://bit.ly/1wo4gsa ) - a handbook designed to assist groups ...
Breaking Medicine News(10 mins):Health News:iFitDress.com: One Shoulder Evening Gown Collection Unveiled Online 2Health News:Urine Test for HPV Works Well, Analysis Finds 2Health News:New Updated 2014 First Time Home Buyer Programs Available to Florida Residents 2Health News:New Updated 2014 First Time Home Buyer Programs Available to Florida Residents 3Health News:Results of DKCRUSH-VI trial reported at TCT 2014 2Health News:NQF Seeks Field Testing Groups for Population Health Guide 2Health News:NQF Seeks Field Testing Groups for Population Health Guide 3
... Cancer (CoC) of the American College of Surgeons has granted ... Cancer Center as a result of surveys performed in 2010. ... to receive this award, is one of a select group ... country. Established in 2004, the CoC Outstanding Achievement ...
... , TUESDAY, April 26 (HealthDay News) -- The increased use ... and rapid angioplasty, has led to a decrease in deaths, ... a Swedish coronary care registry on more than 61,000 patients ... known as STEMI between 1996 and 2007. During those ...
... Sheikh Zayed Institute for Pediatric Surgical Innovation at ,Children,s ... has shown early promise as an option for chronic, severe ... bacterial infections, particularly sepsis. The study, which appears ... , sheds new light on the role of a pain ...
... for publication in The Endocrine Society,s Journal of Clinical ... white children with vitamin D deficiency both had higher fat ... of fat just under their skin and white children were ... internal organs. Studies in adults and children have shown ...
... needs a national pharmacare program and federal leaders must ... ( Canadian Medical Association Journal ) http://www.cmaj.ca/cgi/doi/10.1503/cmaj.110643 ... and New Zealand, Canada lacks a national pharmacare program ... country. Currently, drugs that are covered in some provinces ...
... HealthDay Reporter , TUESDAY, April 26 (HealthDay News) -- ... the risk of developing Alzheimer,s disease, a new study ... to the house causes dementia, and other factors could ... the possible cost of isolation, said lead investigator Bryan ...
Cached Medicine News:Health News:Scott & White Glenda Vasicek Cancer Center receives national achievement award 2Health News:Evidence-Based Heart Attack Care Reduces Deaths: Study 2Health News:Evidence-Based Heart Attack Care Reduces Deaths: Study 3Health News:Study: Resiniferatoxin may increase sepsis-related mortality 2Health News:Vitamin D deficiency is associated with different types of obesity in black and white children 2Health News:Canadians should demand commitments for pharmacare program, says CMAJ 2Health News:Being 'Housebound' Linked to Alzheimer's in Elderly 2Health News:Being 'Housebound' Linked to Alzheimer's in Elderly 3
(Date:9/16/2014)... EVANSVILLE, Ind. , Sept. 16, 2014   ... builder of custom, automated assembly and test systems, recently ... for a leading medical device manufacturer. The Evana solution ... improve quality and ergonomics, as well as reduce labor. ... are automatically fed to Evana,s robotic assembly cell. The ...
(Date:9/16/2014)... 16, 2014   Vestagen Technical Textiles, Inc. ... at hospitals. The myComfort™ line of patient apparel is ... that is fluid repellant, breathable and in studies done ... of bacteria on the fabric i . ... the chain of transmission. We want myComfort to be ...
(Date:9/16/2014)... 16, 2014  Synereca Pharmaceutics, Inc. (SPI), ... active drugs that restore or increase the ... $1.4 million convertible debt financing. Accele Venture ... accelerator Accele Biopharma, Inc., led the financing ... recognized private not-for-profit corporation focused on growing ...
Breaking Medicine Technology:Evana Automation to Supply Robotic Assembly Cell to Leading Medical Device Manufacturer 2Evana Automation to Supply Robotic Assembly Cell to Leading Medical Device Manufacturer 3New Vestagen Patient Garments Aim to Minimize Pathogen Transmission Inside Hospitals 2Synereca Pharmaceuticals Announces Financing Led by Accele Venture Partners 2Synereca Pharmaceuticals Announces Financing Led by Accele Venture Partners 3Synereca Pharmaceuticals Announces Financing Led by Accele Venture Partners 4
... Council (NPC) today welcomed global specialty biopharmaceutical company Shire ... senior vice president, specialty pharma R&D, will serve as ... "The last few years have brought change ... important questions unresolved.  For the pharmaceutical industry, how ...
... Medical, Inc., a Minnesota-based medical device company, has announced that ... eripheral F acilitated A ntegrade S teering ... O cclusions (PFAST-CTOs) study.  The company received approval from ... US based IDE for the peripheral devices and is now ...
Cached Medicine Technology:National Pharmaceutical Council Welcomes Shire as Its Newest Member 2BridgePoint Medical Announces US IDE Approval and First Patient Enrollment of Peripheral Chronic Total Occlusion Study 2
The K-ASSAY® D-Dimer Control set is intended to be used a consistent test sample of known concentration for monitoring the performance of D-Dimer immunoturbidimetric assays....
Microalbumin Linearity Control...
Total IgE Control...
The K-ASSAY Lipid Controls are assayed controls produced from fresh human sera to monitor the accuracy and precision of quantitative lipid determinations of human sera specimens....
Medicine Products: