Navigation Links
Rat Study Sheds Light on Cocaine Addiction
Date:7/9/2010

FRIDAY, July 9 (HealthDay News) -- Researchers report that they've discovered tiny molecules that appear to forestall cocaine addiction in rats and may have the same effect in humans.

The findings, reported in the July 8 issue of the journal Nature, are preliminary, but they "offer promise for the development of a totally new class of anti-addiction medications," said study senior author Paul J. Kenny, an associate professor at Scripps Research Institute in Jupiter, Fla., in a news release from the U.S. National Institute on Drug Abuse (NIDA), which funded the study.

The molecules at issue, known as microRNAs, are a part of RNA and help the body follow the genetic instructions in DNA.

In the study, researchers gave cocaine to rats and discovered that it boosted levels of a specific sequence of microRNA in the brain. The rats disliked cocaine more as the levels went up, but liked it more as they went down.

"This study enhances our understanding of how brain mechanisms, at their most fundamental levels, may contribute to cocaine addiction vulnerability or resistance to it," Dr. Nora D. Volkow, NIDA director, said in the news release.

The findings may help explain why certain people become addicted to cocaine -- an estimated 15 percent of those who try it -- while most do not, the researchers noted.

At the moment, there's no anti-addiction drug to treat cocaine addicts, said addiction specialist Steven Shoptaw in an interview. But this research comes with a caveat, he added: cocaine addiction in rats fails "to fully account for the complexity of cocaine dependence in humans."

On the other hand, the findings "may be the first steps to describing the long sought-after 'switch'" that transforms cocaine use into cocaine addiction, said Shoptaw, a psychologist at the University of California at Los Angeles.

If the research does result in an anti-addiction drug, it will still be a challenge to convince people to use it, said addiction specialist Dr. Adam Bisaga, an associate professor of clinical psychiatry at Columbia University College of Physicians and Surgeons in New York City.

"Even if we have an effective medication, it needs to be a medication that patients are willing to take," Bisaga explained. "Some extremely effective treatments, such as Antabuse for alcohol dependence, are underutilized because these medications require a lot of effort on the part of the doctor to work with patients to accept this treatment."

More information

For more about cocaine, visit the U.S. National Library of Medicine.

-- Randy Dotinga

SOURCES: U.S. National Institute on Drug Abuse, news release, July 7, 2010; Steven Shoptaw, Ph.D., professor, University of California at Los Angeles; Adam Bisaga, M.D., associate professor of clinical psychiatry, Columbia University College of Physicians and Surgeons, New York City


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Study: Medicare policy may account for growing length of hospice stays in nursing homes
2. Study Suggests Link Between HPV, Skin Cancer
3. Drug study shows improvement in major orthopedic surgery care
4. Study suggests link between scleroderma, cancer in certain patients
5. Fish Oil Supplements Linked to Lower Risk of Breast Cancer: Study
6. Study finds patients benefit from thorough discussion of recommended operations
7. Many Docs Deliver Cancer Diagnosis Badly: Study
8. Study: Higher-protein diets support weight loss, but may lower bone density in postmenopausal women
9. Legalizing marijuana in California would lower the price of the drug and increase use, study finds
10. Study shows race, not experience, impacts hiring in sports world
11. 1 in 4 Californian children have never seen a dentist, study finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Rat Study Sheds Light on Cocaine Addiction
(Date:10/13/2017)... IL (PRWEB) , ... October 13, 2017 , ... ... which established the certification process to promote standards of excellence for the field ... Symposium, scheduled for March 22 – 25, 2018 in Orlando, Florida at the ...
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes ... a mock evacuation of the facility as part of a disaster drill on October ... Hose EMS and Shelton City Emergency Manager, as well as the Connecticut Long ...
(Date:10/13/2017)... ... 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out ... free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting ... children of all ages; it is a non-competitive, non-timed event, which is all about ...
(Date:10/13/2017)... , ... October 13, 2017 , ... “The Journey: From ... every danger possible to save lost souls in the Philippines. “The Journey: From the ... is a dedicated teacher of the Bible. She has taught all ages and currently ...
(Date:10/12/2017)... ... ... Planet Fitness, one of the largest and fastest growing franchisors and operators ... location in Covington, LA at 401 N. U.S. Highway 190, in January of 2018. ... in the Holiday Square shopping center. Its location allows it to serve both Covington ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... South Korea , Oct. 4, 2017  South ... its next-generation CPR training aide "cprCUBE" on Kickstarter. The ... chest compression during cardiac arrests with better efficiency compared ... It also offers real-time feedback on efficacy of the ... The crowdfunding campaign has a goal to raise $5,000. ...
(Date:10/4/2017)... Oct. 4, 2017 OBP Medical ... illuminating medical devices, today announced regulatory approval from ... Agency (or Agência Nacional de Vigilância Sanitária (ANVISA)) ... cordless surgical retractor with integrated LED light source ... illumination and exposure of a tissue pocket or ...
(Date:10/2/2017)... Oct. 2, 2017  Eli Lilly and Company (NYSE: ... for the third quarter of 2017 on Tuesday, October ... on that day with the investment community and media ... The conference call will begin at 9 a.m. Eastern ... a live webcast of the conference call through a ...
Breaking Medicine Technology: