Navigation Links
Rat Study Sheds Light on Cocaine Addiction
Date:7/9/2010

FRIDAY, July 9 (HealthDay News) -- Researchers report that they've discovered tiny molecules that appear to forestall cocaine addiction in rats and may have the same effect in humans.

The findings, reported in the July 8 issue of the journal Nature, are preliminary, but they "offer promise for the development of a totally new class of anti-addiction medications," said study senior author Paul J. Kenny, an associate professor at Scripps Research Institute in Jupiter, Fla., in a news release from the U.S. National Institute on Drug Abuse (NIDA), which funded the study.

The molecules at issue, known as microRNAs, are a part of RNA and help the body follow the genetic instructions in DNA.

In the study, researchers gave cocaine to rats and discovered that it boosted levels of a specific sequence of microRNA in the brain. The rats disliked cocaine more as the levels went up, but liked it more as they went down.

"This study enhances our understanding of how brain mechanisms, at their most fundamental levels, may contribute to cocaine addiction vulnerability or resistance to it," Dr. Nora D. Volkow, NIDA director, said in the news release.

The findings may help explain why certain people become addicted to cocaine -- an estimated 15 percent of those who try it -- while most do not, the researchers noted.

At the moment, there's no anti-addiction drug to treat cocaine addicts, said addiction specialist Steven Shoptaw in an interview. But this research comes with a caveat, he added: cocaine addiction in rats fails "to fully account for the complexity of cocaine dependence in humans."

On the other hand, the findings "may be the first steps to describing the long sought-after 'switch'" that transforms cocaine use into cocaine addiction, said Shoptaw, a psychologist at the University of California at Los Angeles.

If the research does result in an anti-addiction drug, it will still be a challenge to convince people to use it, said addiction specialist Dr. Adam Bisaga, an associate professor of clinical psychiatry at Columbia University College of Physicians and Surgeons in New York City.

"Even if we have an effective medication, it needs to be a medication that patients are willing to take," Bisaga explained. "Some extremely effective treatments, such as Antabuse for alcohol dependence, are underutilized because these medications require a lot of effort on the part of the doctor to work with patients to accept this treatment."

More information

For more about cocaine, visit the U.S. National Library of Medicine.

-- Randy Dotinga

SOURCES: U.S. National Institute on Drug Abuse, news release, July 7, 2010; Steven Shoptaw, Ph.D., professor, University of California at Los Angeles; Adam Bisaga, M.D., associate professor of clinical psychiatry, Columbia University College of Physicians and Surgeons, New York City


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Study: Medicare policy may account for growing length of hospice stays in nursing homes
2. Study Suggests Link Between HPV, Skin Cancer
3. Drug study shows improvement in major orthopedic surgery care
4. Study suggests link between scleroderma, cancer in certain patients
5. Fish Oil Supplements Linked to Lower Risk of Breast Cancer: Study
6. Study finds patients benefit from thorough discussion of recommended operations
7. Many Docs Deliver Cancer Diagnosis Badly: Study
8. Study: Higher-protein diets support weight loss, but may lower bone density in postmenopausal women
9. Legalizing marijuana in California would lower the price of the drug and increase use, study finds
10. Study shows race, not experience, impacts hiring in sports world
11. 1 in 4 Californian children have never seen a dentist, study finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Rat Study Sheds Light on Cocaine Addiction
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , the largest ... as the Medical Director of its new Mesquite-Samuell Farm facility. , “We are ... Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the ... In terms of the latter, setting the bar too high can result in disappointment, ... just slow progress toward their goal. , Research from PsychTests.com reveals ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Marcy was in a crisis. Her son James, ... out at his family verbally and physically. , “When something upset him, he couldn’t control ... use it. He would throw rocks at my other children and say he was going ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Comfort Keepers® ... American Cancer Society and the Road To Recovery® program to drive cancer patients to ... and other adults to ensure the highest quality of life and ongoing independence. ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute ... Dr. Barry M. Weintraub as a prominent plastic surgeon and the network’s newest ... world, and the most handsome men, look naturally attractive. Plastic surgery should be ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Roche (SIX: RO, ROG; ... for its Elecsys BRAHMS PCT (procalcitonin) assay as a ... septic shock. With this clearance, Roche is the first ... integrated solution for sepsis risk assessment and management. ... infection and PCT levels in blood can aid clinicians ...
(Date:6/23/2016)... , , , WHEN: ... , , , , LOCATION: , , , Online, with ... , EXPERT PANELISTS:  , , , Frost & Sullivan,s Global Vice ... Senior Industry Analyst, Divyaa Ravishankar and Unmesh Lal, Program Manager , ... industry is witnessing an exceptional era. Several new demand spaces, such ...
(Date:6/23/2016)... MEDIA, Pa. , June 23, 2016 ... treatments in an outpatient dialysis facility.  Treatments are usually ... to 6 hours per visit, including travel time, equipment ... on a patient, but especially grueling for patients who ... residents of a skilled nursing and rehabilitation centers for ...
Breaking Medicine Technology: