Navigation Links
Rat Study Gets at Root of Nicotine Addiction

Blocking a brain cell receptor might help smokers quit, researchers say

WEDNESDAY, Oct. 3 (HealthDay News) -- Research in rats has pinpointed a brain mechanism linked to nicotine dependence and to the anxiety and cravings associated with nicotine withdrawal.

Researchers at the Scripps Research Institute in La Jolla, Calif., said the findings may point to better drugs that can help smokers kick the habit.

In rats, chronic nicotine use recruits a major brain stress system -- the extrahypothalamic corticotropin releasing factor (CRF) system. This contributes to continued nicotine use by exacerbating anxiety and craving whenever nicotine is withdrawn, the researchers found.

The CRF system is located in the amygdala, a brain region that plays a major role in the processing of memory and emotional reactions. The CRF system is activated by CRF-1, an essential protein for coping with stressful events.

"These results suggest long-lasting neuroadaptations of the CRF system, possibly through gene regulation, that may help explain why many cigarette smokers relapse even after a long abstinence from smoking," Olivier George, a research associate at Scripps, said in a prepared statement.

The Scripps team also discovered that giving the rats a compound that blocked these receptors eased the rodents' withdrawal symptoms.

"We reduced the need to take nicotine by blocking CRF-1 receptors in the brain," George said. "We were surprised by the compound's dramatic effectiveness. We don't know yet if the same mechanism is involved in humans with tobacco dependence, but it is very promising."

The study was published this week in an advance online issue of the journal Proceedings of the National Academy of Sciences.

More information

The American Academy of Family Physicians offers tips on how to quit smoking.

-- Robert Preidt

SOURCE: Scripps Research Insitute, news release, Oct. 1, 2007

Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Rural Canadians travel far for specialists: study
2. A new study surpasses Gene Therapy Hurdle
3. Tomato Sauce reduces Cancer Risk- Study
4. A question on study of Adult Stem Cell
5. Study on obesity and heart failure
6. National Lung Study in the process
7. Marijuana gateway theory strengthened by study of twins
8. Old theory of adaptation confirmed by new study
9. Study casts doubt on keyboard ills
10. Gene study links endometriosis, infertility
11. Study reveals how stress can make you sick
Post Your Comments:
(Date:6/27/2016)... ... June 27, 2016 , ... recently awarded their ... Eyeglasses . , Millions of individuals in the United States and Canada wear eyeglasses. ... way to both correct vision and make a fashion statement. Even celebrities use glasses ...
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... PawPaws ... a new product that was developed to enhance the health of felines. The formula ... , The two main herbs in the PawPaws Cat Kidney Support Supplement ...
(Date:6/25/2016)... ... 25, 2016 , ... Austin residents seeking Mohs surgery services, can now turn ... to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization ... selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction ...
(Date:6/25/2016)... Beach, CA (PRWEB) , ... June 25, 2016 , ... ... UCLA with Magna Cum Laude and his M.D from the David Geffen School of ... Diego and returned to Los Angeles to complete his fellowship in hematology/oncology at the ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article ... are unfamiliar with. The article goes on to state that individuals are now more ... these less common operations such as calf and cheek reduction. The Los Angeles area ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Research ... Devices Global Market - Forecast to 2022" report to ... the treatment method for the patients with kidney failure, it ... excess fluid from the patient,s blood and thus the treatment ... potassium and chloride in balance. Increasing number ...
(Date:6/23/2016)... 2016 Research and Markets has ... by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), ... Parenteral) - Global Forecast to 2021" report to ... The global pharmaceutical excipients market is projected to reach ... 6.1% in the forecast period 2016 to 2021. ...
(Date:6/23/2016)... Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that it ... (procalcitonin) assay as a dedicated testing solution for people ... Roche is the first IVD company in the U.S ... assessment and management. PCT is a sepsis-specific ... blood can aid clinicians in assessing the risk of ...
Breaking Medicine Technology: