Navigation Links
Rare medical phenomenon of systemic tumor disappearance following local radiation treatment reported in a patient with metastatic melanoma
Date:3/7/2012

March 8, 2012, NEW YORK A rarely seen phenomenon in cancer patients in which focused radiation to the site of one tumor is associated with the disappearance of metastatic tumors all over the body has been reported in a patient with melanoma treated with the immunotherapeutic agent ipilimumab (Yervoy). Researchers at Memorial Sloan Kettering Cancer Center shared their findings in a unique single-patient study, which could help shed light on the immune system's role in fighting cancer. Their observations suggest that the combination of ipilimumab and radiation may be a promising approach for the treatment of melanoma. The findings are published as a brief report in the March 8 issue of the New England Journal of Medicine. The work was done at Memorial Sloan Kettering's Ludwig Center for Cancer Immunotherapy.

The phenomenon reported by the researchers, known as the abscopal effect, occurs when localized radiation therapy delivered to a single tumor in a patient with advanced disease results in tumor disappearance outside of the irradiated area. Though the abscopal effect is extremely rare, it has been described in several cancers including melanoma, lymphoma, and kidney cancer.

"We are excited about these results, and what we have seen in this one patient proves the principle that adding radiation therapy to immunotherapy may be a promising combination approach to treatment for advanced cancer," explained senior author Jedd Wolchok, MD, PHD, a medical oncologist at Memorial Sloan Kettering Cancer Center with a joint appointment in the Sloan Kettering Institute's Immunology Program. "What we think is happening here is that the immune system's cancer-fighting response is turned up a notch with the addition of focused radiation," added Dr. Wolchok.

In the case study Dr. Wolchok and colleagues reported treating a patient with advanced melanoma using an immunotherapy called ipilimumab, recently approved by the US Food and Drug Admi
'/>"/>

Contact: Jeanne D'Agostino
dagostij@mskcc.org
212-639-3573
Memorial Sloan-Kettering Cancer Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Many U.S. Families Struggle to Pay Medical Bills
2. Computerization May Not Curb Medical Tests, Costs
3. Springer launches 6 new medical review journals
4. Chemists mimic nature to design better medical tests
5. Medical debt keeps rising, new report shows
6. Handheld device for doing blood tests moves closer to medical use
7. Lsuhscs Gee helping address international medical education leadership void
8. Independent medical device review site Which Medical Device launches new Anaesthetics section
9. Scottish medical charity and international drug consortium form partnership
10. Oxford University Press and Medical Council on Alcohol announce long-term partnership
11. Georgetown University Medical Center licenses theranostic for development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)... Acne is a common problem millions of American cope with ... a daily nuisance, for some, it can have a crippling impact ... lead to dramatic mood swings and depression. , Those struggling ... their skin. In some cases, that can make the problem even ... those on a quest for clearer skin can now view ...
(Date:8/30/2014)... 2014 Continuing to meet the skin ... with the addition of a new doctor and office ... provided leading-edge skin care in Grand Rapids since 1980 ... “As a doctor, my passion is making sure my ... Forefront Dermatology, I’m better able to focus on my ...
(Date:8/30/2014)... of colchicine, a plant-based medication commonly used to ... mixed results in reducing potential complications from this ... risk of gastrointestinal adverse effects, according to a ... is being released early online to coincide with ... Congress. , Common complications after cardiac surgery include ...
(Date:8/30/2014)... New York, New York (PRWEB) August 30, 2014 ... consolidated litigation for transvaginal mesh lawsuits ( http://www.injurybeacon.com/transvaginal-mesh/ ... the company’s request to sever four cases selected ... to an Order issued on August 18, 2014, ... Southern District of West Virginia disagrees with Boston ...
(Date:8/30/2014)... One of the most recent dietary trends to have ... meant for sufferers of gluten intolerance and celiac disease, the ... looking to get healthier by simply consuming foods which are ... information erroneous, it also exposes those same consumers to ... change in their food consumption habits. , Because ...
Breaking Medicine News(10 mins):Health News:Acne Treatment Reviews Added to Popular Treatment Website 2Health News:Expanding Care at the Forefront of Dermatology 2Health News:Medication shows mixed results in reducing complications from cardiac surgery 2Health News:Transvaginal Mesh Lawsuit News: Federal Judge Refuses Boston Scientific Request for Separate Trials in Four Bellwether Cases, Bernstein Liebhard LLP Reports 2Health News:Transvaginal Mesh Lawsuit News: Federal Judge Refuses Boston Scientific Request for Separate Trials in Four Bellwether Cases, Bernstein Liebhard LLP Reports 3Health News:“What is Gluten: Three Things You Need to Know Before Adopting a Gluten-Free Diet” Reveals What Readers Need to Know About the Benefits of a Strict Gluten Diet - Vinamy 2
... in the debut issue of SAGEs Foot & Ankle ... J. Stapleton, DPM, and Thomas S. Roukis, DPM, FACFAS, ... foot infections, recommending first controlling the infection by removing ... finally, restructuring the tissue to assure that the wound ...
... for colorectal cancer, which is now recommended to begin ... to 10 years earlier for individuals with a significant ... Medical Center study said. , An examination of 3,450 ... cancer approximately seven years earlier than people who never ...
... Two laptop computers,are missing from Lifeblood,s possession ... protected laptops were used on mobile blood,collection drives, ... names, contact information, blood type, gender,ethnicity, and, in ... is notifying all of the approximately 320,000 affected,individuals ...
... N.C., Feb. 13 Quintiles,Transnational Corp. today announced ... by the College of American Pathologists (CAP)., ... trials in the first,quarter of 2007. The facility ... and analytical capabilities to a growing test menu., ...
... today at a press conference hosted by New York,Attorney ... and a probe of 16 national health insurers regarding ... 13 The following is,attributable to Nancy H. Nielsen, ... by New York Attorney General Andrew,Cuomo calls into question ...
... Alberta study, analyzing a sample of over 275,000 individuals, ... physical activity, one size does not fit all. , ... deciding how and if a person wants to be ... the University of Alberta. It is clear that different ...
Cached Medicine News:Health News:Smokers might benefit from earlier colon cancer screening 2Health News:Two Laptop Computers Missing From Lifeblood's Main Office 2Health News:Quintiles Central Laboratory in India Receives CAP Certification 2Health News:AMA Commends N.Y. Investigation of Health Insurers 2Health News:Study: When it comes to physical activity, one size does not fit all 2
(Date:8/29/2014)... , August 29, 2014 Pixcelldata, ... collaboration software has announced a major new deal with ... by renowned pathology expert, Dr. Marius Nap . ... the 26th European Congress of Pathology which is taking ... ExCeL Arena, London where Pixcelldata ...
(Date:8/29/2014)... , Industry professionals and ... Tweetchat taking place in real-time at CPhI Worldwide  ... UBM Live , announces the launch of ... of its kind global industry-wide Tweetchat for pharma ... aimed to stimulate conversations on key industry issues ...
(Date:8/28/2014)... 28, 2014 Reportlinker.com announces that a ... catalogue: North America Aesthetic Lasers and ... http://www.reportlinker.com/p02343466/North-America-Aesthetic-Lasers-and-Energy-Devices-Market-Outlook-to-2020.html North America ... 2020 Summary GlobalData,s new report, "North ... to 2020", provides key market data on the ...
Breaking Medicine Technology:Pixcelldata Announces New Deal with Dutch Tele-Pathology Specialists eX-Path Ahead of ECP 2014 2CPhI Worldwide to Host #CPhIChat Provoking Debate on the Future of Pharma 2CPhI Worldwide to Host #CPhIChat Provoking Debate on the Future of Pharma 3North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 2North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 3North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 4North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 5North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 6North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 7North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 8North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 9North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 10North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 11North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 12North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 13North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 14North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 15North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 16
... 2011 As interventional cardiologists increasingly ... radial (wrist) access versus femoral (groin or upper ... training and competency guidelines, according to the first ... Intervention,s (SCAI) Transradial Working Group released today at ...
... data presented today at the Society for Cardiovascular ... first to look at the use of highly ... detect restricted blood flow to the heart in ... Preliminary results from the ST-DETECT Trial using high-fidelity ...
Cached Medicine Technology:SCAI Releases First Report on Transradial Access for Angioplasty and Stenting 2SCAI Releases First Report on Transradial Access for Angioplasty and Stenting 3New Data Provide First Look at Ability to Detect Life-Threatening Heart Problems in Some High-Risk Patients 2New Data Provide First Look at Ability to Detect Life-Threatening Heart Problems in Some High-Risk Patients 3
Inquire...
... injection of contrast medium, anesthetic gel, and/or ... eliminates the need for multiple catheterizations. The ... passage into and through the ureter. AQ ... that when activated, attracts and holds water ...
Used for retrograde pyelogram. Supplied sterile in peel-open packages. Intended for one-time use....
Used for the retrieval of stones, stents, or other objects in the urinary tract under direct vision. Retrieval Forceps are designed for use through rigid or flexible endoscopes. Supplied sterile in p...
Medicine Products: