Navigation Links
Rare lung disease cells indicate higher death risk
Date:1/16/2008

CINCINNATILarge numbers of certain cells in the lungs of patients diagnosed with idiopathic pulmonary fibrosis may increase their chance of death, University of Cincinnati (UC) researchers have discovered.

According to a new study, increased numbers of neutrophil (pronounced new-tro-fil) cellsa type of white blood cellin patients lungs were associated with a 30 percent increased risk of mortality in the first year following diagnosis with idiopathic pulmonary fibrosis (IPF).

A measure of cell types in the lungs of IPF patients at the time of diagnosis may allow us to determine their risk of death in the following year, says Brent Kinder, MD, assistant professor of medicine at the UC College of Medicine and pulmonologist with UC Physicians.

This even takes into account other well-known measures of disease severity like age, whether or not the patient smokes and how well his or her lung functions during breathing tests, he adds.

Kinder co-authored the study, which is featured in the January issue of the journal Chest, with colleagues from the University of California, San Francisco (UCSF), and National Jewish Medical Center in Denver, Colo.

IPF is scarring of the lung. As the disease progresses, air sacs in the lungs become replaced by fibrotic scar tissue. Lung tissue becomes thicker where the scarring forms, causing an irreversible loss of the tissues ability to carry oxygen into the bloodstream.

IPF is one of about 200 disorders called interstitial lung diseases (ILDs), which affect the thick tissue of the lung as opposed to more common lung ailmentssuch as asthma or emphysemathat affect the airways.

It is the most common form of ILD and affects about 128,000 people in the United States, with an estimated 48,000 new cases diagnosed each year. There currently are no proven therapies or cures for IPF.

Researchers discovered the link between neutrophils and IPF outcome using bronchoalveolar lavage. The technique involves passing a bronchoscope through the mouth of the patient and into the lungs. Saline is squirted into a small part of the affected lung and then recollected for examination.

The team evaluated the cell count of 156 people with IPF at the time the disease began to make its appearance.

With this information, we can now work to identify neutrophil cells in patients lungs and provide detailed information for more accurate diagnosis, says Kinder, who is also director of the newly established Interstitial Lung Disease Center at UC.

It is our hope that this accurate prognostic information will become even more useful as effective treatments become available.


'/>"/>

Contact: Katie Pence
katie.pence@uc.edu
513-558-4561
University of Cincinnati
Source:Eurekalert

Related medicine news :

1. Smoking belies milder disease but worse prognosis for IPF patients
2. Sickle Cell Disease Pain Can Occur Daily and Is Much More Severe Than Previously Thought
3. MS Drug Tysabri Approved for Crohns Disease
4. Simple online methods increase physician disease reporting
5. Industrial Solvent May Increase Risk for Parkinsons Disease
6. Memantine and Alzheimers disease
7. Nations Leading Dialysis Provider - DaVita - Partners with eDiets(R) to Launch One-of-a-Kind Diet Helper Online Nutrition and Meal Planning Tool for Late-Stage Kidney Disease Patients and Caregivers
8. Years-Long Search Unlocks Deadly Genetic Disease
9. International brain aging expert challenges the existence of Alzheimers as a disease
10. Transplant Drug Shrinks Tumors in Women With Rare Lung Disease
11. LifeMasters Receives Full URAC Disease Management Accreditation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... , ... PurhealthRX , a leading Health and Nutrition Company, is announcing ... full spectrum CBD oil will revolutionize the rapidly growing CBD market by reducing the ... incorporated into liquid products, while reducing costs to end users. , The team of ...
(Date:10/13/2017)... ... 13, 2017 , ... Apple Rehab Shelton Lakes , which specializes in ... the facility as part of a disaster drill on October 3rd. , Apple Rehab ... City Emergency Manager, as well as the Connecticut Long Term Care Mutual Aid ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network for professional women, ... towards gender equality at their inaugural Summit in New York City in June. The ... social audience of over 3 million. To watch the Mobilize Women video, click ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, actor Rob ... sciatica in a new episode of "Success Files," which is an award-winning educational ... and investigates each subject in-depth with passion and integrity. , Sciatica occurs when ...
(Date:10/13/2017)... ... 13, 2017 , ... “America On The Brink”: the Christian history of the ... is the creation of published author, William Nowers. Captain Nowers and his wife, ... he spent thirty years in the Navy. Following his career as a naval ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... Pa. , Oct. 10, 2017   West ... in innovative solutions for injectable drug administration, today shared ... West,s ID Adapter for improving the intradermal administration of ... Fourth Skin Vaccination Summit in May 2017 by Dr. ... Lead, Polio Department, World Health Organization (WHO), and recently ...
(Date:10/5/2017)... ROSEMONT, Ill. , Oct. 5, 2017 /PRNewswire-USNewswire/ ... American Association of Oral and Maxillofacial Surgeons (AAOMS) ... than opioids – to be used as a ... post-surgical pain. ... relationship, the AAOMS White Paper "Opioid Prescribing: Acute ...
(Date:10/4/2017)...  According to the Centers for Disease Control and Prevention (CDC), ... Urgent Care is helping communities across Massachusetts , ... offering no-cost* flu shots through the end of the month. ... regulations. ... a flu shot is by the end of October, according to the ...
Breaking Medicine Technology: