Navigation Links
Rare lung disease cells indicate higher death risk
Date:1/16/2008

CINCINNATILarge numbers of certain cells in the lungs of patients diagnosed with idiopathic pulmonary fibrosis may increase their chance of death, University of Cincinnati (UC) researchers have discovered.

According to a new study, increased numbers of neutrophil (pronounced new-tro-fil) cellsa type of white blood cellin patients lungs were associated with a 30 percent increased risk of mortality in the first year following diagnosis with idiopathic pulmonary fibrosis (IPF).

A measure of cell types in the lungs of IPF patients at the time of diagnosis may allow us to determine their risk of death in the following year, says Brent Kinder, MD, assistant professor of medicine at the UC College of Medicine and pulmonologist with UC Physicians.

This even takes into account other well-known measures of disease severity like age, whether or not the patient smokes and how well his or her lung functions during breathing tests, he adds.

Kinder co-authored the study, which is featured in the January issue of the journal Chest, with colleagues from the University of California, San Francisco (UCSF), and National Jewish Medical Center in Denver, Colo.

IPF is scarring of the lung. As the disease progresses, air sacs in the lungs become replaced by fibrotic scar tissue. Lung tissue becomes thicker where the scarring forms, causing an irreversible loss of the tissues ability to carry oxygen into the bloodstream.

IPF is one of about 200 disorders called interstitial lung diseases (ILDs), which affect the thick tissue of the lung as opposed to more common lung ailmentssuch as asthma or emphysemathat affect the airways.

It is the most common form of ILD and affects about 128,000 people in the United States, with an estimated 48,000 new cases diagnosed each year. There currently are no proven therapies or cures for IPF.

Researchers discovered the link between neutrophils and IPF outcome using bronchoalveolar lavage. The technique involves passing a bronchoscope through the mouth of the patient and into the lungs. Saline is squirted into a small part of the affected lung and then recollected for examination.

The team evaluated the cell count of 156 people with IPF at the time the disease began to make its appearance.

With this information, we can now work to identify neutrophil cells in patients lungs and provide detailed information for more accurate diagnosis, says Kinder, who is also director of the newly established Interstitial Lung Disease Center at UC.

It is our hope that this accurate prognostic information will become even more useful as effective treatments become available.


'/>"/>

Contact: Katie Pence
katie.pence@uc.edu
513-558-4561
University of Cincinnati
Source:Eurekalert

Related medicine news :

1. Smoking belies milder disease but worse prognosis for IPF patients
2. Sickle Cell Disease Pain Can Occur Daily and Is Much More Severe Than Previously Thought
3. MS Drug Tysabri Approved for Crohns Disease
4. Simple online methods increase physician disease reporting
5. Industrial Solvent May Increase Risk for Parkinsons Disease
6. Memantine and Alzheimers disease
7. Nations Leading Dialysis Provider - DaVita - Partners with eDiets(R) to Launch One-of-a-Kind Diet Helper Online Nutrition and Meal Planning Tool for Late-Stage Kidney Disease Patients and Caregivers
8. Years-Long Search Unlocks Deadly Genetic Disease
9. International brain aging expert challenges the existence of Alzheimers as a disease
10. Transplant Drug Shrinks Tumors in Women With Rare Lung Disease
11. LifeMasters Receives Full URAC Disease Management Accreditation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... , ... October 13, 2017 , ... The American Board ... become its next President and Chief Executive Officer, succeeding Dr. James C. Puffer upon ... beginning July 1, 2018 until Dr. Puffer’s retirement at the end of 2018. Upon ...
(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder of ... ElderCounsel, a national organization of elder law and special needs planning attorneys. “Membership in ... It also provides a forum to network with elder law attorneys nationwide,” said Somekh. ...
(Date:10/13/2017)... York, NY (PRWEB) , ... October 13, 2017 , ... ... influential people in business to advocate for action towards gender equality at their inaugural ... views from around the globe, and reached a social audience of over 3 million. ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, ... Development, has been awarded a contract by the Center for Medicare and Medicaid ... to accelerate the enterprise use of Agile methodologies in a consistent and high ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San ... using cutting-edge Oventus O2Vent technology. As many as 18 million Americans are ... cessation in breathing. Oral appliances can offer significant relief to about 75 percent ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... , Sept. 28, 2017 Hill-Rom Holdings, ... 2017 earnings conference call and webcast on Friday, November ... a.m. (EDT) and ending at approximately 8:30 a.m. (CDT) ... discussing the company,s 2017 financial performance and guidance for ... opportunities, initiatives to enhance operational performance, and long-range financial ...
(Date:9/25/2017)... --  Montrium , an industry leader in powerful ... Trial Master Files & Inspection Readiness Conference ( ... Services has selected eTMF Connect to ... a leading European contract research organization (CRO), will ... enable greater collaboration with sponsors, improve compliance and ...
(Date:9/22/2017)... 22, 2017 AVACEN Medical (AVACEN) announced that ... successfully helping those with the widespread pain associated with ... Amanda in Essex, England commented, ... hair, experiencing no sleep at all, tremendous pain, with ... cannot recommend [the AVACEN 100] enough, how this has ...
Breaking Medicine Technology: