Navigation Links
Rare immune cell is asset and liability in fighting infection
Date:8/26/2011

The same trait that makes a rare immune cell invaluable in fighting some infections also can be exploited by other diseases to cause harm, two new studies show.

In papers published online in Immunity, scientists at Washington University School of Medicine in St. Louis reveal that the cells, known as CD8 alpha+ dendritic cells (CD8a+ DCs), can help the body beat back infection by a common parasite, but the same cells can be hijacked by a bacterium to decimate the body's defenses.

The trait that makes the cells both an asset and a liability is the way they alert other immune cells, causing them to attack invaders. CD8a+ DCs can sound the alarm in a manner that is particularly helpful for stripping away invaders' disguises. But this process takes time, and Listeria bacteria can take advantage of that delay to wreak havoc inside the spleen.

"As we've discovered how useful these cells can be in fighting different kinds of infections, researchers have wondered why they're so rare," says Kenneth Murphy, MD, PhD, the Eugene L. Opie First Centennial Professor of Pathology and Immunology. "This may be why overcommitting to any one defensive strategy opens up opportunities for counterstrategies that exploit it."

CD8a+ DCs make up about 10 percent of all dendritic cells in the body. By studying the basic functions of these cells, scientists are laying the groundwork to use them to fight infections. The cells also appear to be essential for some cancer vaccines, which enlist the power of the immune system to help fight tumors.

Murphy, who is a Howard Hughes Medical Institute Investigator, previously created genetically altered mice where CD8a+ DCs could be selectively eliminated. By comparing these mice with normal mice, Murphy and his collaborators have shown that CD8a+ DCs are essential to priming the body's defenses against viral infections.

Viruses often try to disguise themselves to evade defender
'/>"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Thank Neanderthals for That Healthy Immune System, Scientists Say
2. Malaria parasites camouflage themselves from the immune defenses of expectant mothers
3. Strengthening fragile immune memories to fight chronic infections
4. Penn researchers describe key molecule that keeps immune cell development on track
5. Signaling molecule identified as essential for maintaining a balanced immune response
6. Penn study shows link between immune system suppression and blood vessel formation in tumors
7. Genetic study sheds new light on auto-immune arthritis
8. Latest data from Cedars-Sinai vaccine study supports immune targeting of brain tumors
9. NIH scientists reactivate immune cells exhausted by chronic HIV
10. ASCO: Experimental vaccine made from frozen immune cells shows promise for prostate cancer patients
11. Mechanism discovered for health benefit of green tea, new approach to autoimmune disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Rare immune cell is asset and liability in fighting infection
(Date:7/31/2014)... Continuing Education Company Inc ... Clinical Issues in Primary Care Continuing Medical Education ... the Wailea Beach Marriott Resort and Spa on Maui, ... developed for today's Primary Care practitioners. In 5 days ... Barbara Lyons, VP Education. , The agenda for the ...
(Date:7/30/2014)... Vail and Beaver Creek, Colo., skiers ... with “Blind Skier.” Those skiers and guides are enjoying ... Guides , a non-profit organization founded in 2001 that ... (VIPs) for snow sport opportunities. Visually impaired skiers and ... and pick up an application to participate in the ...
(Date:7/30/2014)... Responding to the call to ... to an increasingly diverse patient population, three leading ... expertise to the publication of a new textbook ... and Cultural Competence in Health Care: A Systems ... a professor in the Management Division at the ...
(Date:7/30/2014)... severe combined immunodeficiency (SCID) can be successfully treated with ... led by Memorial Sloan Kettering,s Richard J. O,Reilly, MD, ... Their review will be published in the July 30 ... . , SCID is a group of inherited disorders ... this breakdown occurs, babies no longer have the ability ...
(Date:7/30/2014)... The Restore My Blood Sugar review recently ... sugar levels can now find an amazingly successful method of ... was created by D. Chao and Andrew Forester who claim ... when it comes to normalizing blood sugar levels. Chao actually ... secret to the cure of diabetes that all patients should ...
Breaking Medicine News(10 mins):Health News:Clinical Issues in Primary Care Continuing Medical Education (CME) Conference - October 13-17, 2014 in Maui, Hawaii - Agenda Released 2Health News:Clinical Issues in Primary Care Continuing Medical Education (CME) Conference - October 13-17, 2014 in Maui, Hawaii - Agenda Released 3Health News:Colorado Non-Profit Foresight Ski Guides Seeking Applications for Blind and Visually Impaired Skiers and Guides for Vail Ski Season 2Health News:NLN CEO Co-Authors Textbook to Advance Diversity and Cultural Competence Across Health Care Professions 2Health News:NLN CEO Co-Authors Textbook to Advance Diversity and Cultural Competence Across Health Care Professions 3Health News:Transplantation shown to be highly effective in treating immune deficiency in children 2Health News:Restore My Blood Sugar Review Reveals Exclusive Ways to Normalize Blood Sugar 2
... hand hygiene knowledge positively correlates with a decreased risk ... elementary school children, according to two studies published in ... Infection Control (AJIC), the official publication of APIC ... Epidemiology. In the first study, conducted by ...
... announced that they were among the first to use artificial-lung ... a device invented by two university faculty members, Dr. Joseph ... patients get oxygen into their blood by transporting blood to ... blood before returning it to the heart, bypassing the lungs ...
... -- U.S. meat processor Cargill announced late Wednesday that it ... involving about 36 million pounds of ground turkey linked to ... experts closer to the source of the outbreak, which the ... one Californian and sickened at least 76 others across 26 ...
... HealthDay Reporter , THURSDAY, Aug. 4 (HealthDay News) ... power of stem cells to help treat, and potentially cure, ... recent issue of the Journal of the American Society ... to morph into other types of kidney cells needed to ...
... , THURSDAY, Aug. 4 (HealthDay News) -- Women with the ... to get pregnant than other women, a new study has ... questionnaires at 12 and 18 weeks of gestation. Of those ... their lives, 199 (1.8 percent) had bulimia, and another 82 ...
... Scientific, Technical, Medical, and Scholarly (STMS) publishing business of John ... partnership with The Hastings Center, to publish the Hastings ... field of bioethics. The partnership aims to broaden the reach ... access to libraries. The self-published Report publishes essays, commentary, ...
Cached Medicine News:Health News:Studies shed light on hand hygiene knowledge and infection risk in hospitals and elementary schools 2Health News:New use of artificial lung device pioneered at University of Kentucky 2Health News:Cargill Begins Massive Recall of Turkey Linked to Salmonella Outbreak 2Health News:Cargill Begins Massive Recall of Turkey Linked to Salmonella Outbreak 3Health News:Stem Cell Therapy Holds Promise for Kidney Disease 2Health News:Stem Cell Therapy Holds Promise for Kidney Disease 3Health News:Eating Disorders Can Harm Women's Fertility 2Health News:Hastings Center Report expands reach through Wiley-Blackwell partnership 2
(Date:7/30/2014)... July 30, 2014 Research and Markets has ... - Forecasts to 2019" report to their offering. ... estimated to grow at a lower CAGR in developed countries; however, ... as China , India , ... The growth of the hematology analyzers and reagents market ...
(Date:7/30/2014)... July 30, 2014 Research and Markets ... and Chinese Aseptic Packaging Industry Report 2014" report ... The Global and Chinese Aseptic Packaging ... the current state of the global Aseptic Packaging industry ... report provides a basic overview of the industry including ...
(Date:7/30/2014)... 30, 2014   Unique Pizza and Subs ... Pink: UPZS), a Delaware Corporation, is pleased to ... Larasan Pharmaceutical Corporation ("Larasan"), a nature-based pharmaceutical company that ... agreement, US-based Larasan will work with Unique to ... through Larasan,s vast distribution network throughout ...
Breaking Medicine Technology:Hematology Analyzers & Reagents Market - Forecasts to 2019 2Global and Chinese Aseptic Packaging Industry Report 2014 2Unique Pizza and Subs Announces Asian Distribution Agreement with Larasan Pharmaceutical Corporation 2Unique Pizza and Subs Announces Asian Distribution Agreement with Larasan Pharmaceutical Corporation 3
... Kaiser Permanente Hawaii has received the inaugural Pharmacy ... Permanente,s achievement of a 5-star rating on the PQA ... Centers for Medicare and Medicaid Services (CMS) Star Rating ... because it uses publicly available quality data from CMS," ...
... June 2, 2011 Mylan Inc. (Nasdaq: ... Inc. has received final approval from the U.S. Food ... Application (ANDA) for Venlafaxine Hydrochloride (HCl) Extended-release (ER) Capsules, ... (base), the generic version of Wyeth,s Effexor XR® Capsules, ...
Cached Medicine Technology:PQA Recognizes Kaiser Permanente Hawaii for Excellence in Medication Safety 2
... Direct has been selling replacement ... 1996, and we are extremely ... guarantee. Check out our catalog ... our discount light bulbs specials. ...
... Bulb Direct has been ... Internet since 1996, and we ... 100% satisfaction guarantee. Check out ... and see our discount light ...
... Direct has been selling replacement ... 1996, and we are extremely ... guarantee. Check out our catalog ... our discount light bulbs specials. ...
... Bulb Direct has been selling ... since 1996, and we are ... satisfaction guarantee. Check out our ... see our discount light bulbs ...
Medicine Products: