Navigation Links
Rare disorder gives modelers first glimpse at immune system development
Date:6/16/2009

DURHAM, N.C. -- Children born without thymus glands have given Duke University Medical Center researchers a rare opportunity to watch as a new immune system develops its population of infection-fighting T-cells.

Researchers led by Thomas Kepler, Ph.D., Division Chief of Computational Biology, tracked three young patients after thymus tissue transplantation to measure the growth of a T cell population with all of its diversity. Duke University pioneered thymus transplantation for children born with DiGeorge Syndrome, lacking a thymus, under the direction of Louise Markert, M.D., Ph.D.

As transplanted thymus tissue took hold in the children, the team studied signals related to specific T-cell receptors and more general resources like cytokine signals or space availability. They assessed T cell receptor diversity to determine overall T cell levels and to count T cells of certain kinds.

"What we haven't understood until now is how maintaining the diversity of T cells with different receptors works while a body also maintains appropriate T cell numbers overall," said Kepler, who is senior author of a paper published in PloS Computational Biology. "Our paper is the first to use information about changes in T cell receptor diversity to infer properties of the T cell regulatory mechanisms."

The immune system needs a variety of different T cells to fight all kinds of pathogens. "The fastest way to grow the total T cell population is to impede diversity and grow just a few kinds of T cells," Kepler said. "We set out to understand more about the regulation of this fine balance."

Kepler and lead author Stanca Ciupe, Ph.D., a postdoctoral fellow in computational immunology, created mathematical formulas to model the contribution of resources on the regulation of T cell population growth and diversity. They found that factors that are blind to T cell receptors and treat all T cells alike are a thousand times more commo
'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Gene May Help Spur Obsessive-Compulsive Disorder
2. Bipolar disorder relapses halved by Melbourne researchers
3. New Database to Help Speed Search for Bipolar Disorder Genes
4. Study documents rapid increase in youth bipolar disorder diagnoses
5. School-based overweight prevention program may cut risk of eating disorders among girls
6. APA Comments on FDAs First Approval of Medication to Treat Pediatric Schizophrenia and Bipolar Disorder
7. The Philadelphia Walk Now for Autism Expected to Draw 10,000 Walkers and Raise $1 Million to Help Find Answers About the Nations Fastest-Growing Developmental Disorder
8. University of Iowa professor identifies new eating disorder
9. Pregnancy may increase the risk of developing binge eating disorder
10. UCLA receives $22.5 million to explore the fundamental biology of mental disorders
11. Oncologists are critical in managing psychiatric disorders in patients with advanced cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... HealthDay Reporter THURSDAY, July 10, 2014 (HealthDay ... thought to be cured by immediate and aggressive drug treatment ... AIDS-causing virus in her bloodstream, disappointed federal officials announced Thursday ... remained virus-free even though she stopped taking HIV medications when ... would open the door to a functional cure for all ...
(Date:7/11/2014)... UK (PRWEB) July 11, 2014 Microbiology ... of the in-vitro diagnostics industry, which is expected to ... ten years. The sector owes its growth to the ... to people’s health worldwide and a major factor leading ... technologies, threat of bio-terrorism, and a broader availability of ...
(Date:7/11/2014)... 11, 2014 The report, “Specialty ... Applications & Geography - 2018,” defines and segments ... with an analysis and forecast of the volumes ... fibers (Para aramids, meta aramids, UHMW Polyethylene, carbon ... PPS fiber, PBI fiber, PBO fiber, and liquid ...
(Date:7/11/2014)... Datalogic brings a new and innovative ... wide. With their new Gryphon GD4400 and ... the devastating MRSA, which claimed 5,500 lives, becomes more ... 2D and the Gryphon GM4400-HC 2D readers can scan ... read barcodes off of troublesome LCD monitors, smartphones, and ...
(Date:7/11/2014)... (PRWEB) July 11, 2014 ... least $50 billion in fuel costs now ... The current GHG standards are ... taken it upon themselves to install new ... , 1.    Idle reduction technologies , 2.    Efficient driveline ...
Breaking Medicine News(10 mins):Health News:Mississippi Girl Thought Cured of HIV Shows Signs of Infection 2Health News:Mississippi Girl Thought Cured of HIV Shows Signs of Infection 3Health News:World Virology and Bacteriology Testing Sector Discussed in Comprehensive VPG Research Report Published at MarketPublishers.com 2Health News:World Virology and Bacteriology Testing Sector Discussed in Comprehensive VPG Research Report Published at MarketPublishers.com 3Health News:Specialty Synthetic Fibers & Glass Fiber Market Poised to Reach $20.1 Billion at a CAGR of 5.2% by 2018 – Report by MarketsandMarkets 2Health News:Specialty Synthetic Fibers & Glass Fiber Market Poised to Reach $20.1 Billion at a CAGR of 5.2% by 2018 – Report by MarketsandMarkets 3Health News:Specialty Synthetic Fibers & Glass Fiber Market Poised to Reach $20.1 Billion at a CAGR of 5.2% by 2018 – Report by MarketsandMarkets 4Health News:Stop Spreading Disease with the New Disinfectant-Ready Bar Code Scanner 2Health News:Stop Spreading Disease with the New Disinfectant-Ready Bar Code Scanner 3Health News:LeaseQ Agrees the Latest Round of Greenhouse Gas Rules Could Increase the Cost of Truck Acquisition and Maintenance 2Health News:LeaseQ Agrees the Latest Round of Greenhouse Gas Rules Could Increase the Cost of Truck Acquisition and Maintenance 3
... County residents will have the opportunity to witness a special, ... traditional lighting of the Saugatuck River Bridge at dusk. Those ... the door, will enjoy cuisine and drink from some of ... chance to participate in a silent auction that includes items ...
... VIEW, Calif., July 7 ... has closed its acquisition of the Managed Security Services ... VeriSign is the trusted provider of Internet infrastructure services ... strengthens its leadership position as a global, pure-play security ...
... , MORTON GROVE, Ill., July 7 Lifeway Foods, Inc. (Nasdaq: ... a provider of other natural and organic dairy products, invites you ... throws out the first pitch before the Chicago Cubs take on ... , At this official "Lifeway Day with the Cubs," the local ...
... July 7 /PRNewswire-Asia-FirstCall/ -- Biostar,Pharmaceuticals, Inc. (OTC Bulletin Board: ... and supplier of pharmaceutical,products and medical nutrients addressing a ... has commenced the full implementation of the,new rural cooperative ... Since the beginning of April, Biostar has deployed ...
... Web reports by states and municipalities , TUESDAY, July ... the United States get mixed marks for their use of ... outbreak, a new study shows. , After the U.S. government ... state health departments posted some information about the H1N1 outbreak ...
... the director of Developmental Care and Follow-up at Texas Children,s ... Medicine , has been appointed chair of the American Academy ... assumed the role on July 1st and will oversee the ... succeed Ann Stark, M.D., FAAP, chief of Neonatology at Texas ...
Cached Medicine News:Health News:Al's Angels' 'Angels in July' Saugatuck River Bridge Lighting to Benefit Children in Need 2Health News:SecureWorks Closes Acquisition of VeriSign's Managed Security Services Business 2Health News:SecureWorks Closes Acquisition of VeriSign's Managed Security Services Business 3Health News:SecureWorks Closes Acquisition of VeriSign's Managed Security Services Business 4Health News:Giant Bugs Invade Wrigley Field 2Health News:Biostar Pharmaceuticals, Inc. Commences the Full Implementation of New Rural Cooperative Supply Network Plan 2Health News:Biostar Pharmaceuticals, Inc. Commences the Full Implementation of New Rural Cooperative Supply Network Plan 3Health News:Mixed Marks for Swine Flu Updates 2Health News:The American Academy of Pediatrics Names Lu-Ann Papile, M.D., FAAP, as Chair of the Fetus and Newborn Committee 2Health News:The American Academy of Pediatrics Names Lu-Ann Papile, M.D., FAAP, as Chair of the Fetus and Newborn Committee 3
(Date:7/11/2014)... 11, 2014 Patient engagement has become ... organizations are turning to an assortment of marketing ... part of this evolving approach to patient engagement, ... and engage patients throughout their experiences with a ... By mapping the patient journey and employing a ...
(Date:7/11/2014)... , July 11, 2014 Research ... "Global Hypodermic Needles Market 2014-2018" report to their ... A hypodermic needle is a hollow needle commonly ... body or or to extract fluids from it. A ... or to inject substances that cannot be ingested. Hypodermic ...
(Date:7/11/2014)... -- Research and Markets ( http://www.researchandmarkets.com/research/tjlw9k/immunoprotein ) has ... Testing Market - Forecasts to 2019: Expected to ... is expected to be valued at USD 4,943.0 ... http://photos.prnewswire.com/prnh/20130307/600769 The ... according to immunoprotein types which include immunoglobulins, complement ...
Breaking Medicine Technology:New Study Uses Six-Step Patient Journey as Framework for Consumer-Focused Marketing Opportunities 2Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 2Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 3Immunoprotein Diagnostic Testing Market - Forecasts to 2019: Expected to grow at the highest CAGR of 6% and is expected to be valued at USD 4,943.0 million 2
... and ABBOTT PARK, Ill., June 24, 2011 New ... The New England Journal of Medicine show ... and type 2 diabetes receiving bardoxolone methyl for 52 ... the treatment period, as measured by estimated glomerular filtration ...
... 24, 2011 , Comprehensive , F ... ow , A vailable in Canada, U.K. ... world-leading provider of scientific, technical and,medical information products and services, ... of the United States, enabling,institutions to identify international funding opportunities. ...
Cached Medicine Technology:New Phase 2 Data Published in New England Journal of Medicine Show Bardoxolone Methyl Sustained Improvement in Measure of Kidney Function (eGFR) Over 52 Weeks in Patients With Moderate to Severe Chronic Kidney Disease and Type 2 Diabetes 2New Phase 2 Data Published in New England Journal of Medicine Show Bardoxolone Methyl Sustained Improvement in Measure of Kidney Function (eGFR) Over 52 Weeks in Patients With Moderate to Severe Chronic Kidney Disease and Type 2 Diabetes 3New Phase 2 Data Published in New England Journal of Medicine Show Bardoxolone Methyl Sustained Improvement in Measure of Kidney Function (eGFR) Over 52 Weeks in Patients With Moderate to Severe Chronic Kidney Disease and Type 2 Diabetes 4Elsevier's SciVal Funding Expands Globally 2Elsevier's SciVal Funding Expands Globally 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: