Navigation Links
Rare case explains why some infected with HIV remain symptom free without antiretroviral drugs
Date:8/11/2008

can effectively halt disease progression by a pathogenic form of HIV," says Blankson, an assistant professor at the Johns Hopkins University School of Medicine.

"Moreover, the strength of the immune response was not dependent on infection by a weakened form of the virus. And if we can harness the means by which these elite white blood cells stop the virus, then we can hopefully 'teach' or reprogram white blood cells in others to also target HIV," he says.

Included in the blood analysis was genetic testing which confirmed that both husband and wife were infected with the same pathogenic strain of HIV and ruled out the possibility that there were genetic deficiencies in the virus that infected the wife.

Genetic testing also confirmed that both husband and wife had an overactive strand of genetic material tied to gene HLA B57, found in previous studies to be more common in those whose HIV infection was suppressed or slowed.

"The presence of this genetic spot is a discordant result that strongly contradicts theories that various genetic factors alone play a protective role in suppression," says Blankson.

He notes that study findings revealed a beneficial side effect to spurring the immune system cells to attack HIV.

Using new laboratory tests that precisely measure the immune response to various strains of HIV, researchers first tested T-cells from both the wife and husband to see if their immune system cells suppressed viral replication. They found that activated T-cells from the wife stalled HIV replication by as much as 90 percent, while the husband's T-cells stopped it by only 30 percent.

In subsequent genetic analyses, the viral strain in the wife's blood was found to have at least two mutations known to weaken the virus, while the viral strain in the husband's blood had fewer mutations affecting fitness.

According to Blankson, the stronger immune system in elite suppression not only lo
'/>"/>

Contact: David March
dmarch1@jhmi.edu
410-955-1534
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Study Explains How Cranberries Prevent Urinary Infections
2. Fat Grafting Provides Permanent, Natural Looking Results - Dr. Michael Law Explains Fat Injections as a New Trend in Facial Plastic Surgery
3. Bestselling Author Dr. Timothy Brantley Explains the Connection of Food and Mood
4. Fact Sheet Explains Cleaners, Disinfectants
5. New Resource Explains What Seniors Can Do if Medicare Denies Coverage of Their Medicines
6. Study finds circumcision safe in both HIV-infected and HIV-uninfected men
7. Spectranetics Introduces New Device for Removal of Non-Functional and Infected Cardiac Leads
8. Some Facelift Patients Infected With MRSA Superbug
9. What are the predominant bacilli in the intestines ducklings infected with S. enteritidis?
10. Vicriviroc Demonstrates Potent and Sustained Viral Suppression Through 48 Weeks of Therapy in Treatment-Experienced HIV-Infected Patients
11. Antidepressants Help HIV-Infected Patients Stick to Treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... Alan Mozes HealthDay ... When it comes to emergency room waiting times, patients seeking ... time staring down the clock than those seen at smaller ... of crowding and our ability to provide timely emergency care ... of the authors of the new research, Dr. Renee Hsia, ...
(Date:9/18/2014)... proven it true: exercise is good for you. But ... exercise may have an added benefit for cancer patients ... model of melanoma, found that combining exercise with chemotherapy ... Libonati, an associate professor in the School of Nursing ... Nursing Research, was the senior author on the study, ...
(Date:9/18/2014)... TayganPoint Consulting Group, a leading strategic ... co-founder John Cassimatis was named as one of ... recognizing the region’s top healthcare and life science ... the year. , The Innovation Awards celebrate companies ... to shape the medical industry in Greater Philadelphia ...
(Date:9/18/2014)... Savannah, GA (PRWEB) September 18, 2014 ... awarded the Alex Ormond, Jr. Leadership Award by the ... toward improving healthcare and wellness throughout the nation and ... to receive this award,” said Ben. “The Savannah Science ... for 65 years and multiple generations have gone through ...
(Date:9/18/2014)... group of international scientists have developed a new method ... here . , The Wildlife Conservation Society (WCS)-led research, ... Diseases , describes the use of fecal samples from ... been exposed to the virus. This represents a new ... potentially change the way Ebola virus is studied and ...
Breaking Medicine News(10 mins):Health News:ER Waiting Times Vary Significantly, Studies Find 2Health News:ER Waiting Times Vary Significantly, Studies Find 3Health News:Exercise boosts tumor-fighting ability of chemotherapy, Penn team finds 2Health News:TayganPoint Executive Receives Prestigious Award from Philadelphia Business Journal 2Health News:Quirk Awarded the Alex Ormond, Jr. Leadership Award by the Savannah Science Seminar 2Health News:Research yields a game changer for improving understanding of Ebola and great apes 2Health News:Research yields a game changer for improving understanding of Ebola and great apes 3
... such as having trouble remembering recent events may indicate ... than typical age-related changes. These findings, which are published ... Society, indicate that primary care clinicians, who are ... about their memory, should be aware that such complaints ...
... SEATTLE The number of cases and deaths from breast ... the developing world where more women are dying at younger ... for Health Metrics and Evaluation (IHME) at the University of ... in just three decades, from 641,000 cases in 1980 to ...
... 14, 2011, advance online edition of the New ... hepatitis C who took a combination medicationa telaprevir-based regimen ... weeks were cured. Usually, the treatment is administered ... treatment is unnecessary, possibly changing the standard of care ...
... , WEDNESDAY, Sept. 14 (HealthDay News) -- How ... much you consume in determining the risk of heart ... binge drinking, defined as having seven drinks a day for two ... increased risk for atherosclerosis or "hardening of the arteries" caused by ...
... Alan Mozes HealthDay Reporter , WEDNESDAY, Sept. ... cluster of factors known as the "metabolic syndrome" could ... obese patients without such factors, new research suggests. ... -- increased blood pressure, higher-than-normal insulin levels, excess body ...
... 14 (HealthDay News) -- Some children are born with natural ... Johns Hopkins University researchers tested the "number sense" of ... tests included having the kids look at groups of ... guess which group had more dots. Kids were also ...
Cached Medicine News:Health News:Some memory complaints in the elderly may be warning signs of cognitive problems 2Health News:More women dying from breast and cervical cancer at a younger age in developing countries 2Health News:More women dying from breast and cervical cancer at a younger age in developing countries 3Health News:Shorter treatment with hepatitis C drug combination may be more beneficial, study shows 2Health News:Drinking Patterns Affect Heart Health, Mouse Study Finds 2Health News:Drinking Patterns Affect Heart Health, Mouse Study Finds 3Health News:Certain Risk Factors Could Spur Heart Failure in Normal-Weight People 2Health News:Certain Risk Factors Could Spur Heart Failure in Normal-Weight People 3Health News:Certain Risk Factors Could Spur Heart Failure in Normal-Weight People 4Health News:Trouble With Math? Blame Your Lack of 'Numbers Sense' 2
(Date:9/18/2014)... Sept. 18, 2014  ADM Tronics Unlimited, Inc. ... Ph.D. to its corporate Advisory Board for business ... at the Harvard Medical School and Visiting Professor ... received his Masters degree in Electronics Engineering and ... University of Bologna. After spending a year as ...
(Date:9/18/2014)... Sept. 18, 2014 MiMedx Group, Inc. ... processor and marketer of patent protected regenerative biomaterials ... today that it has entered into a distribution ... will provide its dehydrated human amnion/chorion membrane ("dHACM") ... exclusively on a private label basis. ...
(Date:9/18/2014)... and PLAINSBORO, N.J. , ... its support of the National Hemophilia Foundation,s (NHF) ... which provides support to people with hemophilia and ... psychosocial challenges that can impede disease management. The ... Communication With Your Provider About Pain , ...
Breaking Medicine Technology:ADM Tronics Appoints Gianluca DeNovi, Ph.D. To Advisory Board 2ADM Tronics Appoints Gianluca DeNovi, Ph.D. To Advisory Board 3MiMedx Signs Distribution Agreement With Zimmer 2MiMedx Signs Distribution Agreement With Zimmer 3Novo Nordisk Supports National Hemophilia Foundation Initiative for "Collaborating in Care" Disease Management Program 2Novo Nordisk Supports National Hemophilia Foundation Initiative for "Collaborating in Care" Disease Management Program 3
... survival,in the SPARC Phase 3 trial consistently demonstrate ... patients receiving,satraplatin. These analyses included prior Taxotere use,geographies, ... -- The two,major causes of progression in the ... were each associated with a 36%,reduction in relative ...
... co-primary endpoints, Wake After Sleep Onset and Total,Sleep Time, ... met at both doses - Evotec to host a,conference ... today , HAMBURG, Germany | OXFORD, England, June 4, ... top-line,results from its first phase II clinical trial of ...
Cached Medicine Technology:Additional New Data from Satraplatin SPARC Phase 3 Investigational,Trial Presented at ASCO Annual Meeting 2Additional New Data from Satraplatin SPARC Phase 3 Investigational,Trial Presented at ASCO Annual Meeting 3Additional New Data from Satraplatin SPARC Phase 3 Investigational,Trial Presented at ASCO Annual Meeting 4Additional New Data from Satraplatin SPARC Phase 3 Investigational,Trial Presented at ASCO Annual Meeting 5Additional New Data from Satraplatin SPARC Phase 3 Investigational,Trial Presented at ASCO Annual Meeting 6Additional New Data from Satraplatin SPARC Phase 3 Investigational,Trial Presented at ASCO Annual Meeting 7Evotec AG (DE) - Evotec Reports Positive Proof-of-Concept Top-Line,Results with ... 2Evotec AG (DE) - Evotec Reports Positive Proof-of-Concept Top-Line,Results with ... 3Evotec AG (DE) - Evotec Reports Positive Proof-of-Concept Top-Line,Results with ... 4
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: