Navigation Links
Rare case explains why some infected with HIV remain symptom free without antiretroviral drugs
Date:8/11/2008

AIDS experts at Johns Hopkins say they have compelling evidence that some people with HIV who for years and even decades show extremely low levels of the virus in their blood never progress to full-blown AIDS and remain symptom free even without treatment, probably do so because of the strength of their immune systems, not any defects in the strain of HIV that infected them in the first place.

Their conclusions about so-called elite suppressors, published this month in the Journal of Virology, come from rigorous blood and genetic studies from a monogamous, married, African-American couple in Baltimore, in which the wife was infected through sex with her husband more than a decade ago.

Unlike her husband, the wife remains symptom free, has consistently had viral counts of fewer than 50 copies per cubic milliliter of blood, and has not needed any treatment to keep the disease in check. The husband, as a so-called progressor, takes a potent drug cocktail to keep his infection from developing into full-blown AIDS, as demonstrated by viral counts in the hundreds of thousands per cubic milliliter of blood. The couple has been married for two decades and the husband was an intravenous drug user.

The scientists say the case study disproves some suspect theories about elite suppression that suggest it always involves a defective or "weakened" viral strain, which is easier for the immune system to attack, or that genetic variants confer a protective effect in suppressors.

"This is an extremely rare case of co-infection in a controlled, monogamous relationship, which showed us how a strong immune system in the elite suppressor kept the virus from replicating and infecting other cells," says senior study investigator and infectious disease specialist Joel Blankson, M.D., Ph.D.

"Our findings offer hope to vaccine researchers because they reveal that the immune system's primary offense, known as CD8 killer T-cells,
'/>"/>

Contact: David March
dmarch1@jhmi.edu
410-955-1534
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Study Explains How Cranberries Prevent Urinary Infections
2. Fat Grafting Provides Permanent, Natural Looking Results - Dr. Michael Law Explains Fat Injections as a New Trend in Facial Plastic Surgery
3. Bestselling Author Dr. Timothy Brantley Explains the Connection of Food and Mood
4. Fact Sheet Explains Cleaners, Disinfectants
5. New Resource Explains What Seniors Can Do if Medicare Denies Coverage of Their Medicines
6. Study finds circumcision safe in both HIV-infected and HIV-uninfected men
7. Spectranetics Introduces New Device for Removal of Non-Functional and Infected Cardiac Leads
8. Some Facelift Patients Infected With MRSA Superbug
9. What are the predominant bacilli in the intestines ducklings infected with S. enteritidis?
10. Vicriviroc Demonstrates Potent and Sustained Viral Suppression Through 48 Weeks of Therapy in Treatment-Experienced HIV-Infected Patients
11. Antidepressants Help HIV-Infected Patients Stick to Treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... According to the Kidney Disease Solution book review recently updated ... what to do to eliminate the root cause of ... review that readers can easily learn what foods to avoid ... Vkool also informs in its Kidney Disease Solution review that ... naturally. The book consists of a collection of natural remedies ...
(Date:7/13/2014)... A Xarelto lawsuit webpage has been launched ... with the most current information regarding serious internal bleeding ... as well as the growing number of Xarelto ... The law firm is now offering free legal evaluations ... bleeding and related complications while using Xarelto, including:, ...
(Date:7/13/2014)... WA (PRWEB) July 13, 2014 ... Woolcott, who commented, “As a parent of a special ... underserved need in the Seattle community for contemporary special ... provide an important alternative to students and families in ... best practices and environment for special education. We welcome ...
(Date:7/13/2014)... Arbor, MI (PRWEB) July 13, 2014 If ... learning program he has just launched at http://www.HealthYourself101.com ... of visceral obesity. , Power has set out to ... its ill effects that’s actually – dare we say it? ... “The program,” says Power, “aims to engage the remote learner ...
(Date:7/13/2014)... 2014 According to the Living With ... a comprehensive guide that features a series of tips ... (keratosis pilaris). This guide consists of 14 chapters ... Pilaris? ,     Chapter 2: What Cause KP? , ... Have KP? ,     Chapter 4: Keratosis Pilaris Treatment ...
Breaking Medicine News(10 mins):Health News:Kidney Disease Solution Book Review Exposes Duncan Capicchiano's Newly Updated Kidney Disease Treatment Plan – Vkool.com 2Health News:Kidney Disease Solution Book Review Exposes Duncan Capicchiano's Newly Updated Kidney Disease Treatment Plan – Vkool.com 3Health News:Xeralto Lawsuit Page Launched By Wright & Schulte LLC To Provide Information On Potential For Xarelto Bleeding Side Effects, Growing Litigation 2Health News:Xeralto Lawsuit Page Launched By Wright & Schulte LLC To Provide Information On Potential For Xarelto Bleeding Side Effects, Growing Litigation 3Health News:Xeralto Lawsuit Page Launched By Wright & Schulte LLC To Provide Information On Potential For Xarelto Bleeding Side Effects, Growing Litigation 4Health News:New Private School, Emerald City School, Founded in Downtown Seattle Now Accepting 1st to 6th Grade Students Who Learn Differently 2Health News:Retired Ann Arbor Physician and Professor Wields New Media to Teach Health Science 2Health News:Retired Ann Arbor Physician and Professor Wields New Media to Teach Health Science 3Health News:Retired Ann Arbor Physician and Professor Wields New Media to Teach Health Science 4Health News:Living With KP Book Review Exposes Jennifer Richards' Keratosis Pilaris Guide – Vkool.com 2Health News:Living With KP Book Review Exposes Jennifer Richards' Keratosis Pilaris Guide – Vkool.com 3
... Mukesh Haikerwal, said today that the Government could save as ... if it allowed GPs to refer patients directly for Magnetic ... proposal are contained in the AMA's Federal Budget Submission 2007-08, ... GPs currently have to refer patients to other specialists for ...
... burn out. Apart from it affecting productivity in one's job, ... Scientists. //This study supports the various academic endeavors which has ... pressure, metabolic syndrome, flu, and heart disease. ,A ... Type 2 Diabetes was almost 1.8 times pronounced in people ...
... & Reproductive Sciences at Yale School of Medicine and ... who are into regular bicycling experienced reduced genital sensation ... the genitals. , ,The researchers undertook ... 22 women runners. With the help of non-invasive techniques, ...
... helped her deal with her split from Brad Pitt.// ... and body back in shape, according to imdb.com. ... commenced with yoga and adds, "I was in need of being ... Coldplay, The Rolling Stones and Alicia Keyes during yoga and adds, ...
... contaminated drug syringes are the main reasons for the rise in ... Delhi, Mumbai and Chennai, states a new study. ,"Poor ... have sex with men. In Bangalore, for example, three in four ... virus is transmitted, and a large proportion of them engaged in ...
... is here that would thrill every gourmet. It is great ... year. It is a full course meal, daubed in rich, ... ,Brian Wansink is the brain behind this unique literary ... Food and Brand Laboratory. Truly a gourmet, who enjoys every ...
Cached Medicine News:Health News:Competitive women cyclists experience reduced genital sensation 2Health News:Homosexuality, drug abuse increasing HIV in India: study 2Health News:Whet your appetite with “Mindless Eating”: A gourmet's deligh 2Health News:Whet your appetite with “Mindless Eating”: A gourmet's deligh 3
(Date:7/10/2014)... , 11. Juli 2014  Dilon ... für die molekulare Bildgebung, einschließlich molekularer ... die CE-Zulassung für sein Navigator ® ... Dilon das Produkt jetzt europaweit vertreiben. ... Großteil der europäischen Länder ausgedehnt und ...
(Date:7/10/2014)... Yesterday, former Congressman Patrick Kennedy ... facility. Rep. Kennedy and Dick Moberg ... research in neurological disease and treatment. ... Garen Staglin , created One Mind, a ... that will radically accelerate the development and implementation ...
(Date:7/10/2014)... 10, 2014   LabStyle Innovations Corp . ... announced the appointment of Professor Richard B. ... Board of Directors. Prof. Stone brings ... to LabStyle as an entrepreneur, venture capitalist public, ... governance expert. He currently serves on the board ...
Breaking Medicine Technology:Dilon erhält CE-Zulassung für sein Navigator-Gamma-Sondensystem 2Representative Patrick Kennedy visits Moberg's medical device facility to discuss improvement in brain injury care 2LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 2LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 3LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 4