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Rare brain blood vessel disease carries higher risks in females
Date:9/10/2012

tal of 717 revascularization procedures, as most patients had arterial blockage on both sides of the brain. This type of "bilateral" disease was more common in females.

Females were more than twice as likely to have transient ischemic attacks (TIAs)sometimes called "mini-strokes"as a symptom of moyamoya disease before surgery. However, there was no sex-related difference in the rate of more serious strokes.

After surgical revascularization, both male and female patients had significant improvements in health and functioning after surgery, with similar outcomes between the sexes. However, over five years after successful surgery, women and girls were about twice as likely to experience some type of adverse event, including stroke or death: 11.4 versus 5.3 percent.

The new study is the largest series of patients treated for moyamoya disease in North America. "These data suggest that sex may play an underappreciated role in influencing the natural history and posttreatment course in patients with moyamoya disease," the researchers write. Their findings suggest that moyamoya disease may have a "more aggressive nature" in women.

Nevertheless, Dr. Steinberg and coauthors emphasize that most patientswomen as well as menhave excellent results after revascularization for moyamoya disease. Although adverse outcomes are more common in females, the overall risk of further problems is relatively low. The researchers call for further study to understand "the role of sex-specific influences on the pathophysiology of moyamoya disease."


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Contact: Connie Hughes
Connie.Hughes@wolterskluwer.com
646-674-6348
Wolters Kluwer Health
Source:Eurekalert

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