Navigation Links
Rare bone diseases and their dental, oral and craniofacial manifestations
Date:4/14/2014

Alexandria, Va., USA The International and American Associations for Dental Research (IADR/AADR) have published a paper titled "Rare Bone Diseases and Their Dental, Oral, and Craniofacial Manifestations." The complete review by researchers Sunday O. Akintoye, Andrea B. Burke, Alison M. Boyce, Michael Collins, Brian L. Foster, Rachel I. Gafni, Janice S. Lee, Mary Scott Ramnitz, Martha J. Somerman and J. Timothy Wright is published in the OnlineFirst portion of the IADR/AADR Journal of Dental Research (JDR).

Hereditary diseases affecting the skeleton are heterogeneous in etiology and severity. Though many of these conditions are individually rare, the total number of people affected is great. These disorders often include dental-oral-craniofacial (DOC) manifestations, but the combination of the rarity and lack of in-depth reporting often limit our understanding and ability to diagnose and treat affected individuals.

In this insightful and thorough review, researchers focused on dental, oral and craniofacial manifestations of rare bone diseases. Discussed in this report are defects in four key physiologic processes in bone/tooth formation that serve as models for the understanding of other diseases in the skeleton and DOC complex: progenitor cell differentiation (fibrous dysplasia), extracellular matrix production (osteogenesis imperfecta), mineralization (familial tumoral calcinosis/hyperostosis hyperphosphatemia syndrome, hypophosphatemic rickets, and hypophosphatasia), and bone resorption (Gorham-Stout disease). For each condition, the authors highlight causative mutations (when known), etiopathology in the skeleton and DOC complex, and treatments.

By understanding how these four foci are subverted to cause disease, the researchers aimed to improve the identification of genetic, molecular, and/or biologic causes, diagnoses, and treatment of these and other rare bone conditions that may share underlying mechanisms of disease.

"On behalf of the Journal of Dental Research, I thank the authors of this comprehensive review on rare bone diseases for publication in the Journal Special Supplement on Clinical Research," said JDR Editor William Giannobile. "This research contributes to our knowledge and understanding of rare bone diseases and further paves the way for the treatment of these diseases."


'/>"/>

Contact: Ingrid L. Thomas
ithomas@iadr.org
703-299-8084
International & American Associations for Dental Research
Source:Eurekalert

Related medicine news :

1. Analysis finds less research attention given to diseases of the poor
2. Possible explanation for human diseases caused by defective ribosomes
3. A versatile mouse that can teach us about many diseases and drugs
4. Prion discovery could help keep deadly brain diseases in check
5. The Most Contagious Diseases in Retirement Communities
6. Life Insurance for Seniors and the Importance of Preventing Chronic Diseases
7. OHSU researchers develop new drug approach that could lead to cures for wide range of diseases
8. From common colds to deadly lung diseases, 1 protein plays key role
9. Flexcin International, Inc. Revs Up New Flexcin Website to Help Adults Suffering With Arthritis and Other Joint Diseases
10. National Foundation for Infectious Diseases Supports 2013 National Influenza Vaccination Week
11. The Angular Cheilitis-Free Forever Book Teaches People How To Prevent Or Remove Their Skin Diseases Naturally And Effortlessly – Vinamy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2017)... NY (PRWEB) , ... April 25, 2017 , ... A ... stress at work can also decrease overall productivity and performance in the workplace. The ... employees. , During the last few weeks of April, Clearview Resolution Services will be ...
(Date:4/25/2017)... Boulder, CO (PRWEB) , ... April 25, 2017 ... ... Law and Liberty attempts to compare student test score performance for the 2015-16 ... one of the state’s voucher programs. Though it highlights important patterns in student ...
(Date:4/25/2017)... ... April 25, 2017 , ... Lake Park Dental is now ... Invisalign® in Lutz, FL. With the help of this highly-effective, yet convenient ... fewer potential complications, more discretion and less pain. , Drs. Sarah Jockin, Nicole ...
(Date:4/25/2017)... ... April 25, 2017 , ... As pharmaceutical companies ... to help with process innovation in drug formulation and manufacturing. CoreRx offers ... state-of-the-art analytical equipment in support of their development and manufacturing goals. , ...
(Date:4/25/2017)... ... , ... Back Pain Centers of America (BPC), which connects people ... their area, announces the launch of a new and proprietary customer relationship management (CRM) ... reputable physicians to help them with back or neck pain and helps to match ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... , April 19, 2017 ... an immune response in pets such as canine, ... are of various types such as Attenuated Live ... Vaccines, DNA Vaccines and Recombinant Vaccines. Attenuated live ... virus or bacteria, which have been weakend under ...
(Date:4/19/2017)... 2017  SARES•REGIS Group leased the first of ... Conejo Spectrum Business Park in Thousand ... Inc. , a biopharmaceutical company developing meaningful therapies ... have been underserved by scientific innovation, with an ... autoimmune and infectious disease. Before commencement ...
(Date:4/18/2017)... April 18, 2017 Viverae ® , a ... the integration of IBM ® Watson Campaign Automation, ... targeted communications for a personalized experience. Through digital engagement, ... their health in real time. The enhanced experience drives ... to members, wherever they are in their journey to ...
Breaking Medicine Technology: