Navigation Links
Rare bone diseases and their dental, oral and craniofacial manifestations
Date:4/14/2014

Alexandria, Va., USA The International and American Associations for Dental Research (IADR/AADR) have published a paper titled "Rare Bone Diseases and Their Dental, Oral, and Craniofacial Manifestations." The complete review by researchers Sunday O. Akintoye, Andrea B. Burke, Alison M. Boyce, Michael Collins, Brian L. Foster, Rachel I. Gafni, Janice S. Lee, Mary Scott Ramnitz, Martha J. Somerman and J. Timothy Wright is published in the OnlineFirst portion of the IADR/AADR Journal of Dental Research (JDR).

Hereditary diseases affecting the skeleton are heterogeneous in etiology and severity. Though many of these conditions are individually rare, the total number of people affected is great. These disorders often include dental-oral-craniofacial (DOC) manifestations, but the combination of the rarity and lack of in-depth reporting often limit our understanding and ability to diagnose and treat affected individuals.

In this insightful and thorough review, researchers focused on dental, oral and craniofacial manifestations of rare bone diseases. Discussed in this report are defects in four key physiologic processes in bone/tooth formation that serve as models for the understanding of other diseases in the skeleton and DOC complex: progenitor cell differentiation (fibrous dysplasia), extracellular matrix production (osteogenesis imperfecta), mineralization (familial tumoral calcinosis/hyperostosis hyperphosphatemia syndrome, hypophosphatemic rickets, and hypophosphatasia), and bone resorption (Gorham-Stout disease). For each condition, the authors highlight causative mutations (when known), etiopathology in the skeleton and DOC complex, and treatments.

By understanding how these four foci are subverted to cause disease, the researchers aimed to improve the identification of genetic, molecular, and/or biologic causes, diagnoses, and treatment of these and other rare bone conditions that may share underlying mechanisms of disease.

"On behalf of the Journal of Dental Research, I thank the authors of this comprehensive review on rare bone diseases for publication in the Journal Special Supplement on Clinical Research," said JDR Editor William Giannobile. "This research contributes to our knowledge and understanding of rare bone diseases and further paves the way for the treatment of these diseases."


'/>"/>

Contact: Ingrid L. Thomas
ithomas@iadr.org
703-299-8084
International & American Associations for Dental Research
Source:Eurekalert

Related medicine news :

1. Analysis finds less research attention given to diseases of the poor
2. Possible explanation for human diseases caused by defective ribosomes
3. A versatile mouse that can teach us about many diseases and drugs
4. Prion discovery could help keep deadly brain diseases in check
5. The Most Contagious Diseases in Retirement Communities
6. Life Insurance for Seniors and the Importance of Preventing Chronic Diseases
7. OHSU researchers develop new drug approach that could lead to cures for wide range of diseases
8. From common colds to deadly lung diseases, 1 protein plays key role
9. Flexcin International, Inc. Revs Up New Flexcin Website to Help Adults Suffering With Arthritis and Other Joint Diseases
10. National Foundation for Infectious Diseases Supports 2013 National Influenza Vaccination Week
11. The Angular Cheilitis-Free Forever Book Teaches People How To Prevent Or Remove Their Skin Diseases Naturally And Effortlessly – Vinamy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/4/2016)... ... December 03, 2016 , ... Penrose ... in the Dallas area” Tuesday evening at the 26th Annual SMU Cox Dallas ... SMU's Cox School’s Caruth Institute for Entrepreneurship. Dallas 100™, co-founded by the Caruth ...
(Date:12/2/2016)... California (PRWEB) , ... December 02, 2016 , ... Halfway ... Dental Medicine has provided preventative dental services to more than 15,900 children 5 years ... First 5 LA pledged $38 million over a span of five years to Western ...
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... ... across the Dothan-Wiregrass Area in Alabama are expected to attend the UNCF Dothan-Wiregrass ... will help provide scholarship funds for area students and operating support to UNCF-member ...
(Date:12/2/2016)... ... , ... U.S. Surgeon General, Dr. Vivek Murthy, graces the cover of the ... inspired to practice medicine at an early age by his father, who was also ... and prescribing medicine,” he states. “It is about building relationships with people; relationships that ...
(Date:12/2/2016)... ... December 02, 2016 , ... Mediaplanet is ... USA Today, which covers the innovative treatments, therapeutic technologies, and revolutionized nutrition that ... “We are prolonging life 6 years in the last 3 decades,” says Dr. ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... the largest share in the ECG Cables And ECG Leadwires ... remote monitoring ECG devices. On the other hand, the ... the highest growth rate during the forecast period. ... Company (U.S.), Medtronic plc ( Ireland ), Koninklijke ... Medical International Limited ( China ), held major ...
(Date:12/2/2016)... Research and Markets has announced the addition of the "Global ... report to their offering. ... , The global ultrasound device market ... to grow at a CAGR of 5.5% during 2016-2022. Based on portability, ... forecast period, a CAGR of 8.8% in the global market. Among the ...
(Date:12/2/2016)... , Dec. 2, 2016  PipelineRx, a leading medication ... be offering demonstrations of its SaaS-based telepharmacy platform, ... Health-System Pharmacists 2016 Midyear Clinical Meeting and Exhibition, ... . With nearly 300 hospital clients nationally, the ... technology designed to dramatically improve pharmacy operations, enhance ...
Breaking Medicine Technology: