Navigation Links
Rare Genetic Syndrome May Increase Colon Cancer Risk
Date:12/10/2010

FRIDAY, Dec. 10 (HealthDay News) -- Patients diagnosed with a genetic condition known as Cowden syndrome face an increased risk for colon cancer, new research suggests.

And because such patients typically have a larger-than-normal head circumference, head size should be used as a screening marker for such elevated cancer risk, the study's authors say.

Cowden syndrome has already been associated with several other cancers, the researchers noted. The syndrome affects about one in every 200,000 people, they said.

"What this means is that people with big heads -- defined as greater than 58 centimeters in men and 57 centimeters in women -- should see a genetic counselor to determine whether they should be screened for colon, breast, thyroid and uterine cancers," Dr. Charis Eng, chairman of the Genomic Medicine Institute at the Cleveland Clinic's Lerner Research Institute and the study's lead researcher, said in a clinic news release.

The findings are reported in the December issue of Gastroenterology.

While exploring the characteristics of Cowden syndrome, the research team found a larger-than-normal head size in about 75 percent of people with the genetic mutation that causes the syndrome. Previous estimates had been 25 percent.

Their analysis, which involved 127 Cowden syndrome patients, also revealed that a similarly large percentage have gastrointestinal polyps, which increase the risk of early-onset colorectal cancer.

The research team also found an association between a known cause of Cowden -- an abnormality in the so-called PTEN gene -- and a 200 times greater risk for developing colorectal cancer.

"Before these findings, I told my patients that there's no need for unusually aggressive colon cancer screenings," Eng said. "As we can see now from our research, however, we need to start screening these patients for colon cancer in their early- to mid-30s at the latest, and it should be annual screenings, not every 10 years."

More information

The U.S. National Library of Medicine has more on Cowden syndrome.

--Alan Mozes

SOURCE: Cleveland Clinic, news release, Dec. 7, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Chinese Study Suggests New Way to Test for Genetic Diseases
2. New discovery prevents symptoms of rare genetic disorder
3. Genetic mutations associated with increased PSA and prostate cancer
4. Novel genetic mutation that causes the most common form of eye cancer discovered
5. Rare, Severe Form of Morning Sickness Appears to Be Genetic
6. Our normal genetics may influence cancer growth, too
7. Academies of science call for amendments to impracticable Genetic Diagnostics Act
8. New research shows genetic test for lung cancer risk prompts smokers to quit
9. Genetic Deletion Linked to Raised Risk of Autism, Schizophrenia
10. ASHG 2010: New research on implications of direct-to-consumer and clinical genetic testing
11. Possible Genetic Switches for Blood Sugar Control Detected
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Rare Genetic Syndrome May Increase Colon Cancer Risk
(Date:8/18/2017)... ... ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh in Abilene, Texas, has released ... pertaining to the mother of the Savior whom the world calls “Mother Mary”. Yisrayl says ... the role of this historical woman. , “The world bows, kisses the feet of, ...
(Date:8/18/2017)... ... ... “Dangerous Inheritance”: a mystery about saving the family farm. “Dangerous Inheritance” is the ... was raised on a farm. As Diane wrote this story, she used fond ... mantra of ‘neighbors helping neighbors’ have always been a large part of her farming ...
(Date:8/18/2017)... ... August 18, 2017 , ... “Kingdom Mandate for Kingdom ... Kingdom. “Kingdom Mandate for Kingdom Builders” is the creation of published author, John ... to Eastern Europe as a missionary in 1983. He spent three decades training ...
(Date:8/17/2017)... Waltham, Mass (PRWEB) , ... August 17, 2017 ... ... high use by health care organizations and considered extremely effective, very effective, or ... “Leading Physicians and Physician Leadership”. , NEJM Catalyst Insights Reports are based on ...
(Date:8/17/2017)... ... August 17, 2017 , ... Georgia Urology, the largest ... Hebert to its newest location in East Cobb (4800 Olde Towne ... come aboard,” said Dr. Mark A. Haber, Georgia Urology’s managing partner. “She brings a ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... HOUSTON , Aug. 15, 2017   Mostyn Law ... in Houston, Texas . The Mostyn Law ... the past 2 years. That is why Mostyn Law ... Texas to show its appreciation. Blood supplies ... to fall 5% short of hospital needs in August. That is ...
(Date:8/15/2017)... 15, 2017  Axium Pharmaceuticals Inc., the creator of the drug ... the beginning stages of an IPO. The United ... the average cost of a prescription epilepsy drug being $450.00-$1200.00 for a ... AXIUM PHARMACEUTICALS, INC ... Another staggering figure is the fact that Americans spent $42 ...
(Date:8/15/2017)... , Aug. 15, 2017  AOTI Inc. announced today that ... Therapy Inc., has recently opened a New York City Office in ... usage of its unique Topical Wound Oxygen (TWO 2 ) homecare ... the Accreditation Commission for Health Care (ACHC) under the company,s DMEPOS ... ...
Breaking Medicine Technology: