Navigation Links
Rare Genetic Syndrome May Increase Colon Cancer Risk

FRIDAY, Dec. 10 (HealthDay News) -- Patients diagnosed with a genetic condition known as Cowden syndrome face an increased risk for colon cancer, new research suggests.

And because such patients typically have a larger-than-normal head circumference, head size should be used as a screening marker for such elevated cancer risk, the study's authors say.

Cowden syndrome has already been associated with several other cancers, the researchers noted. The syndrome affects about one in every 200,000 people, they said.

"What this means is that people with big heads -- defined as greater than 58 centimeters in men and 57 centimeters in women -- should see a genetic counselor to determine whether they should be screened for colon, breast, thyroid and uterine cancers," Dr. Charis Eng, chairman of the Genomic Medicine Institute at the Cleveland Clinic's Lerner Research Institute and the study's lead researcher, said in a clinic news release.

The findings are reported in the December issue of Gastroenterology.

While exploring the characteristics of Cowden syndrome, the research team found a larger-than-normal head size in about 75 percent of people with the genetic mutation that causes the syndrome. Previous estimates had been 25 percent.

Their analysis, which involved 127 Cowden syndrome patients, also revealed that a similarly large percentage have gastrointestinal polyps, which increase the risk of early-onset colorectal cancer.

The research team also found an association between a known cause of Cowden -- an abnormality in the so-called PTEN gene -- and a 200 times greater risk for developing colorectal cancer.

"Before these findings, I told my patients that there's no need for unusually aggressive colon cancer screenings," Eng said. "As we can see now from our research, however, we need to start screening these patients for colon cancer in their early- to mid-30s at the latest, and it should be annual screenings, not every 10 years."

More information

The U.S. National Library of Medicine has more on Cowden syndrome.

--Alan Mozes

SOURCE: Cleveland Clinic, news release, Dec. 7, 2010

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Chinese Study Suggests New Way to Test for Genetic Diseases
2. New discovery prevents symptoms of rare genetic disorder
3. Genetic mutations associated with increased PSA and prostate cancer
4. Novel genetic mutation that causes the most common form of eye cancer discovered
5. Rare, Severe Form of Morning Sickness Appears to Be Genetic
6. Our normal genetics may influence cancer growth, too
7. Academies of science call for amendments to impracticable Genetic Diagnostics Act
8. New research shows genetic test for lung cancer risk prompts smokers to quit
9. Genetic Deletion Linked to Raised Risk of Autism, Schizophrenia
10. ASHG 2010: New research on implications of direct-to-consumer and clinical genetic testing
11. Possible Genetic Switches for Blood Sugar Control Detected
Post Your Comments:
Related Image:
Rare Genetic Syndrome May Increase Colon Cancer Risk
(Date:11/25/2015)... , ... November 25, 2015 , ... Finnleo, a leader ... Eve on several models of traditional and far-infrared saunas. , For traditional ... is the most traditional Finnish sauna wood, and Finnleo uses only European Grade A ...
(Date:11/25/2015)... ... November 25, 2015 , ... Dr. John Pierce, Medical Director at ... hair loss treatment with the Capillus272™ Pro laser therapy cap. FDA cleared for safety ... fuller hair, without the need for surgery, prescription pills, or topical foams. , ...
(Date:11/25/2015)... ... November 25, 2015 , ... For the first time, Vitalalert is donating half ... ” campaign. The partnership between the two groups began in 2014 with Vitalalert pledging ... , MAP International was founded in 1954 and is an international Christian-based health organization ...
(Date:11/25/2015)... ... November 25, 2015 , ... Dental professionals who would like to ... are invited to attend Dr. Mark Iacobelli’s Advanced Implant Mentoring (AIM) CE course. Courses ... , As the co-founders of Advanced Implant Mentoring (AIM), Dr. Iacobelli and Dr. ...
(Date:11/25/2015)... Crystal Lake, IL (PRWEB) , ... November 25, 2015 , ... ... pleased to announce a recent successful appellate decision obtained by Attorneys Francisco J. Botto ... the case Adcock v. Illinois Workers’ Compensation Comm’n, 2015 IL App (2d) 130884WC. , ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... 26, 2015 ... of the  "2016 Future Horizons and ... Surface Marker Testing Market: Supplier Shares, ... their offering.  --> ... the  "2016 Future Horizons and Growth ...
(Date:11/25/2015)...  The total global healthcare industry is expected to grow ... Latin America has the highest projected growth at ... Japan ), is second with growth projected at 11.5%. ... healthcare expenditure. In 2013-2014, total government funded healthcare was nearly ... to 41.2% in 2013-2014. In real terms, out of pocket ...
(Date:11/25/2015)... WASHINGTON , Nov. 25, 2015  The ... Obstetricians and Gynecologists (ACOG), and the March of ... bipartisan Protecting Our Infants Act of 2015 ... the number of newborns born exposed to drugs, ... Since the bill,s introduction, all three organizations have ...
Breaking Medicine Technology: