Navigation Links
Rapid method to detect BRAF mutations in cancer tissue samples
Date:10/22/2013

BOSTON A new diagnostic platform to detect BRAF mutations in melanoma and other cancer types is faster and more accurate compared with the standard method currently used in clinics, and this could help accelerate diagnosis and treatment, according to results presented here at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, held Oct. 19-23.

About 50 percent of melanomas, and less frequently other cancer types, harbor mutations in the BRAF oncogene. To date, more than 30 different cancer-associated BRAF mutations have been identified. The most common are the BRAF V600 mutations.

The new molecular diagnostics (MDx) prototype platform developed by Biocartis in Mechelen, Belgium, can detect BRAF V600 mutations in about 90 minutes, requires no sample preparation, and is 95 percent in agreement with the standard method approved by clinical laboratory improvement amendments (CLIA).

"When you do molecular testing for BRAF mutations the way it is done in the clinic, it often takes three to four weeks to get the results back. A lot of that time is spent preparing the sample, including laser microdissection to isolate DNA from the tumor cells," said Filip Janku, M.D., Ph.D., an oncologist at MD Anderson Cancer Center in Houston, Texas. "With the MDx platform, it takes about two minutes to add fresh, frozen, or paraffin-embedded tumor samples to the sample cartridge and less than 90 minutes to get the results. This platform is capable of giving you an answer in an absolutely unprecedented time frame.

"We used MDx to detect BRAF mutations as a proof of principle. This new platform will be capable of detecting a variety of mutations, including KRAS, EGFR, and others for which there are FDA-approved targeted therapies," he added. "Unfortunately, we are still not in a position to offer targeted therapies to patients as soon as they come to the clinic, because it takes time to do molecular testing.
'/>"/>

Contact: Lauren Riley
lauren.riley@aacr.org
215-446-7155
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Rapid Insight Announces Dynamic Online Learning Series for Predictive Analytics
2. Las Vegas Rapid Detox Clinic Celebrates 500 Rapid Opiate Detox Patient Milestone
3. Net Worth Commerce TV Airs in Cedar Rapids, Iowa
4. Rapid Opiate Detox in 8 Hours at Las Vegas Rapid Detox Medical Clinic
5. Hormone Treatments / Diet Doc Hormone Diets & Weight Loss Plans Announce Healthy Diet Plans that Promote Rapid Weight Loss Leading to Less Risk of Blocked Arteries
6. Rapid Protect Launches New Improved Web Interface for Its Popular Rapid Tracker Family Safety Mobile Apps
7. 500 Rapid Opiate Detox Treatments Successfully Performed by Las Vegas Rapid Detox Medical Clinic
8. Chequed.com Continues Rapid Growth with New Customer Wins and Corporate Expansions
9. Diet Doc Hormone Diets & Weight Loss Plans Offers New Diet Plans that Promote Safe and Rapid Weight Loss for a Good Night’s Sleep and Reduced Food Costs
10. Perleche Treatment
11. How “Angular Cheilitis Cure Rapid 3 Hour Remedy” Helps People Get Healthy Skin – Healthreviewcenter
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/4/2015)... , ... September 04, 2015 , ... Lalonde Gordon ran ... and followed up with victory in the men’s 400 meters final, with an impressive ... and Field Championships in San Jose, Costa Rica in August 2015. The 44.64 time ...
(Date:9/4/2015)... ... September 04, 2015 , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has ... involving the Pope’s upcoming trip to the United States. , Yisrayl lays out what he ... the Vatican and society is. Yisrayl also provides the meaning of his own name and ...
(Date:9/4/2015)... ... ... Friday night, Chicago lovebirds Jenny McCarthy and Donnie Wahlberg celebrated their one-year ... families affected by autism, raising nearly $250,000. , 150 guests, including event co-chairs ... Swan Inn to support the cause. , McCarthy tugged the heartstrings of everyone ...
(Date:9/3/2015)... ... September 03, 2015 , ... Allied Anesthesia is proud to ... is the norm not the exception. , St. Jude was recently named one of ... Stroke Association, making it one of only 10 hospitals in the state to earn ...
(Date:9/3/2015)... New York (PRWEB) , ... September 03, 2015 , ... ... Do”. William Mattar, Esq. believes this does not stop at any certain demographic ... captioning to its newly produced one-minute, thirty-, fifteen- and ten-second TV commercials. , The ...
Breaking Medicine News(10 mins):Health News:Lalonde Gordon’s Recipe Brings Home the Gold 2Health News:Lalonde Gordon’s Recipe Brings Home the Gold 3Health News:Yisrayl Hawkins Writes Open Letter to Pope Francis In Light of Approaching U.S. Visit 2Health News:Jenny McCarthy & Donnie Wahlberg Help Raise Over $200,000 For Generation Rescue’s ‘Night Of Hope’ Chicago Charity Event 2Health News:Allied Anesthesia Physicians Announce Partnership with St. Jude 2Health News:Allied Anesthesia Physicians Announce Partnership with St. Jude 3Health News:Law Firm Focused on “Helping People” Continues to Expand on Vision 2
... ophthalmologist at UT Southwestern Medical Center has helped create a ... disease better track vision changes. With the hand-held digital ... in less than 90 seconds, said Dr. Yu-Guang He, associate ... do not have timely eye exams and end up suffering ...
... [EMBARGOED FOR JULY 26, 2011] Antibiotic overuse and resistance ... decades. Following an outbreak of Clostridium difficile infections, which ... Quebec, Canada targeted physicians and pharmacists with an education ... study published in Clinical Infectious Diseases and ...
... July 25 (HealthDay News) -- Parents of children with attention-deficit/hyperactivity disorder ... than 10 years old with ADHD may be unable to cross ... that while children with ADHD may look as if they are ... look both ways before crossing -- they aren,t always good at ...
... gravel roads in Dunn County, North Dakota, they stir up ... wake contain such high levels of the mineral erionite that ... an increased risk of developing mesothelioma, a type of cancer ... is a natural mineral fiber that shares similar physical similarities ...
... July 25 (HealthDay News) -- Although many Americans continue ... likely to remain on the job after they turn ... The researchers also found that lower-income workers are ... particularly arthritis, later in life. As a result, the ...
... MONDAY, July 25 (HealthDay News) -- People who resume smoking ... die than those who quit for good, a new Italian ... relapsed were three to five times more likely to die ... need to do more to support long-term ,smoking-cessation efforts after ...
Cached Medicine News:Health News:UT Southwestern ophthalmologist helps develop device for monitoring degenerative eye disease 2Health News:Simple guidelines decreased unnecessary antibiotic use in Quebec, Canada 2Health News:Kids With ADHD Less Adept at Crossing the Street: Study 2Health News:Kids With ADHD Less Adept at Crossing the Street: Study 3Health News:New study finds cancer-causing mineral in US road gravel 2Health News:New study finds cancer-causing mineral in US road gravel 3Health News:Blue-Collar Employees With Arthritis Working Past 65: Study 2Health News:Smoking After Heart Attack Raises Risk of Dying 2
(Date:9/4/2015)... MILWAUKEE , Sept. 4, 2015  Dohmen Company ... speaker for the Metropolitan Milwaukee Association of Commerce,s annual ... 10 at the Pfister Hotel. The ,Future 50, Awards ... established businesses and young firms headquartered in the seven-county ... Dohmen has called Milwaukee home ...
(Date:9/4/2015)... Sept. 4, 2015  Luminex Corporation (NASDAQ: LMNX ... Morgan Stanley Global Healthcare Conference to be held September ... in New York City . ... Eastern time on Friday, September 18, 2015.  The presentation ... Corporation,s website at http://www.luminexcorp.com . Simply log on to ...
(Date:9/4/2015)... September 4, 2015 According to ... (Plasmapheresis, Plateletpheresis, Erythrocytapheresis, Leukapheresis, and Photopheresis) by Procedure (Therapeutic ... Product - Global Forecast to 2020", published by MarketsandMarkets, ... 2.5 Billion by 2020, growing at a CAGR of ... Browse 139 Tables and 45 F ...
Breaking Medicine Technology:Dohmen CEO Cynthia LaConte to Keynote MMAC 'Future 50' Awards Luncheon 2Luminex Corporation To Present At The Morgan Stanley Global Healthcare Conference 2Apheresis Market Worth 2.5 Billion USD by 2020 2Apheresis Market Worth 2.5 Billion USD by 2020 3Apheresis Market Worth 2.5 Billion USD by 2020 4Apheresis Market Worth 2.5 Billion USD by 2020 5
... Wis., May 15 Omega 3 fatty acids ... a credible natural,alternative and may have beneficial effect ... study reveals. While several studies have reported,beneficial effects ... Vectomega(R) could have specific positive effects on,impulse control., ...
... NEW YORK and WASHINGTON, May 14 Revolution ... up to offer patients and,physicians the largest personalized ... United States. Individuals can quickly assess their,eligibility for ... confidential,and efficient way through an online search engine ...
Cached Medicine Technology:Omega 3 Fatty Acids Bound to Phospholipids has Potential Benefit for Attention-Deficit Hyperactivity Disorder (ADHD) 2Omega 3 Fatty Acids Bound to Phospholipids has Potential Benefit for Attention-Deficit Hyperactivity Disorder (ADHD) 3Revolution Health and EmergingMed Launch Cancer Clinical Trial Matching and Referral Service 2
... VERSASTEP™ Plus Short Instrument ... , ,The VERSASTEP™ Plus ... Working Length is a unique ... applications in laparoscopic procedures. It ...
... Trocar consists of a blunt obturator connected ... assembly. , ,The valve body assembly ... to prevent gas leakage when instruments are ... Trocar includes built-in converters to allow insertion ...
... Premium One-Step™ single-use system device is comprised ... device components for creating each access port ... , Step™ insufflation and access needle, ... separately. , Step™ radially expandable sleeve, 100 ...
... contains an internal seal to prevent gas leakage ... of pneumoperitoneum. The 5 mm PLUS system includes ... mm - 12 mm as appropriate and is ... of the trocar to allow insertion of smaller ...
Medicine Products: