Navigation Links
Raloxifene Cuts Risk of Certain Type of Breast Cancer
Date:6/11/2008

And the benefits weren't limited to high-risk women, study finds

WEDNESDAY, June 11 (HealthDay News) -- A drug already approved to reduce the risk of breast cancer in high-risk women also seems to cut the risk for other women.

A new analysis finds that those who took raloxifene (Evista) regularly over a number of years were less likely to develop invasive estrogen-receptor (ER) positive breast cancer, compared with women who did not take the drug.

Raloxifene did not, however, cut the risk for noninvasive breast cancer or invasive ER-negative cancers.

"This is a reaffirmation that the drug raloxifene is a very powerful SERM [selective estrogen receptor modulator] for reducing the risk of invasive breast cancer," said Dr. Jay Brooks, chief of hematology/oncology at Ochsner Health System in Baton Rouge, La.

The study, published in the June 10 online issue of the Journal of the National Cancer Institute, was funded by Eli Lilly and Co., which makes Evista.

SERMs block the female hormone estrogen by binding to estrogen receptors; estrogen helps fuel the growth of some breast cancers. Raloxifene and other hormonal therapies have an "estrogenic tickle" effect, explained V. Craig Jordan, author of an accompanying editorial in the journal and vice president and research director for medical science at Fox Chase Cancer Center in Philadelphia. Jordan did some of the early laboratory research on raloxifene.

Raloxifene was originally developed to prevent and treat osteoporosis, and only later was found to help reduce the risk of invasive breast cancer in high-risk women.

The new study expands on the original results of the RUTH (Raloxifene Use for the Heart) trial, originally designed to see if raloxifene, which has cholesterol-lowering properties, could reduce the risk of dying from coronary heart disease.

The trial involved more than 10,000 postmenopausal women with coronary heart disease or at risk for the condition. Participants were randomly chosen to receive either daily raloxifene or a placebo and followed for a median of 5.6 years.

Raloxifene turned out not to have any effect on heart disease mortality risk, but it did reduce the risk of invasive breast cancer by 44 percent, which translates into 1.2 women per 1,000 treated for one year who were spared the agony of a breast cancer diagnosis.

The new analysis looked more specifically at raloxifene's effect on breast cancer and found a 55 percent lower incidence of invasive ER-positive tumors, but no effect on noninvasive breast cancer or invasive ER-negative breast cancer.

According to the study authors, these findings are consistent with results from other trials involving women without heart disease. This trial and others found an increased risk of blood clots and fatal strokes among women taking raloxifene, indicating that women need to weigh the risks and benefits of the drug.

Another question is how long to take raloxifene for breast cancer prevention, although the authors speculated that up to eight years might be safe and effective.

"We're learning more about this class of drugs, what works and what doesn't work," Jordan said. "[Raloxifene] is good for osteoporosis, no good for coronary heart disease, but breast cancer is inhibited."

More information

The U.S. National Cancer Institute has more on SERMs and how they work.



SOURCE: V. Craig Jordan, Ph.D., vice president and research director, medical science, Fox Chase Cancer Center, Philadelphia; Jay Brooks, M.D., chairman, hematology/oncology, Ochsner Health System, Baton Rouge, La.; June 10, 2008, Journal of the National Cancer Institute, online


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Raloxifene Safe for Women With Decreased Kidney Function
2. Consumers Urged to Avoid Certain Tomatoes Amid Salmonella Scare
3. Demonstrating the Value of Benchmarking in an Uncertain Economy
4. St. Jude finds young age may give survival advantage to children with certain brain tumors
5. Certain Tests in ERs Raise Cancer Risk for Some
6. Study Showed ALIMTA(R) (pemetrexed for injection) Improved Survival in Certain Types of Non-Small Cell Lung Cancer
7. Gypsum Wallboard from CertainTeeds Moundsville, W. Va., Plant and Roofing Shingles among Building Materials Donated to St. Jude Dream Home(R)
8. Regular prostate-specific antigen screening may be discontinued in certain elderly populations
9. Experimental drug shows promise in treating certain lymphomas
10. Study finds certain liver disease related to cardiovascular fitness
11. Womens Risk for a Certain Skin Cancer Varies by Geography
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... Texas (PRWEB) , ... January 24, 2017 , ... ... year introduces more changes during the Annual Enrollment Period (AEP) and the Open ... scrambling looking for health insurance coverage. Mainly, people are witnessing higher deductibles, rising ...
(Date:1/24/2017)... ... , ... The Cruise Web Inc. was recognized today as Northeast ... Annual MSC True Partnerships’ Awards. , The 2016 MSC True Partnerships Awards are ... on overall business growth in revenue and guests and continuous partnership support and innovative ...
(Date:1/24/2017)... (PRWEB) , ... January 24, 2017 , ... ... solutions, announced that it has officially formed a distribution partnership with Byers ... the industrial odor management industry. , Through the agreement, OMI Industries formulated a ...
(Date:1/24/2017)... ... January 24, 2017 , ... Providing ... a new report from the Frank Hawkins Kenan Institute of Private Enterprise ... leaders, academics and policy makers identified concrete solutions at the “What’s Next, America?” ...
(Date:1/24/2017)... ... January 24, 2017 , ... Date ... , Sharon Kleyne, the nation’s foremost water advocate and host of the ... Your Health on Voice America, once again welcomed one of her favorite guests ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... -- In a major study released this weekend from ... 1 ( http://www.multivu.com/players/English/7899551-nephrocheck-test-acute-kidney-injury-outcomes/ ), Astute Medical,s ... patients at high risk of Acute Kidney Injury ... control trial led by Alexander Zarbock , ... standard of care or a treatment per Kidney ...
(Date:1/24/2017)... , Jan. 24, 2017 Market Research Future has a half ... Wound Closure Device is growing rapidly and expected to continue its growth ... ... CAGR of 5% from 2013 to 2019 and reaching a value of ... forecasted period, 2016-2022 Global Wound Closure Device Market has been ...
(Date:1/24/2017)... Jan. 24, 2017  The Orthopaedic Implant Company ... high-value orthopaedic implants, announced the launch of its ... The OIC Tibial Nail System is designed ... proximal and distal screw holes accommodate varying fracture ... dynamization.  The nail is available in diameters of ...
Breaking Medicine Technology: