Navigation Links
'Rain Man' mice provide model for autism
Date:9/7/2007

mal littermates and preferred to spend time with inanimate objects.

The engineered mice were significantly better than normal, though, at learning a water maze, in which they had to find and learn the location of an underwater platform. They were also better at relearning a new position of the platform after it was moved.

When you manipulate a brain, you usually dont improve it, Dr. Sdhof said. The fact that we get an improvement is very good. It shows were changing something specific; were affecting how the brain processes information.

Other tests of coordination, anxiety and motor ability showed normal results, indicating that the changes in brain activity were specific, Dr. S dhof said.

The researchers also studied the patterns of electrical activity in the brain. Normally, some nerve cells halt, or inhibit, other nerve cells from firing, while others excite action in their neighbors. An imbalance in the normal pattern is thought to be involved in autism.

Nerve cells from the genetically engineered mice showed a significantly greater inhibitory action than their normal littermates, even though only about 10 percent of the normal amount of neuroligin-3 was present. This finding was a surprise, as other studies have indicated that a loss of inhibitory action might be involved in autism spectrum disorders, the researchers said.

The results indicate that focusing on inhibitory action might be a way to treat autistic behaviors, said Dr. Sdhof, director of the Gill Center for Research on Brain Cell Communication and the C. Vincent Prothro Center for Research in Basic Neuroscience. He is a Howard Hughes Medical Institute investigator at UT Southwestern.


'/>"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Use of Cellular Phones associated with Increased risk of Brain Tumors
2. Brain death – How to cope with it
3. Multi billion-dollar suit filed against cell phone firm for causing brain tumours
4. “Brain fingerprinting”- The new lie detectr
5. Nasal Spray Could Take Drugs Direct to Brain.
6. Two doctors suspended for wrong brain surgery
7. The brain loves a surprise
8. African HIV strains more resistant to anti HIV drugs
9. Virus Combats Brain Tumour
10. Increase in sugar...decrease in brain function!!!
11. Alcohol shrinks brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2015)... The National Association of Professional Women ... 2015-2016 inductee into the NAPW VIP Woman of the ... for leadership in oral healthcare. NAPW is the nation's ... than 700,000 members and over 200 operating Local Chapters. ... group of professional women," said NAPW President Star Jones. ...
(Date:5/4/2015)... Montreal, CANADA (PRWEB) May 04, 2015 ... development of innovative proofreading technologies, today announced that ... #438 at the Music City Center, in Nashville ... Proofware is the world's first true all-in-one we-based ... everyone involved in the security of their brand ...
(Date:5/4/2015)... (PRWEB) May 04, 2015 The ... Group today launched a new initiative at UC ... next generation of physicians committed to advancing Latino ... Ser Medicos, or Preparing Students to Be Physicians, ... that will provide scholarships, mentorship and internship opportunities, ...
(Date:5/4/2015)... (PRWEB) May 04, 2015 Getting patients ... manage their health is critical to achieving the “triple ... reducing costs, but this will require a shift in ... also demands that health systems move beyond their traditional ... took part in the third live meeting of the ...
(Date:5/4/2015)... 04, 2015 The American Telemedicine Association ... policy reports which identify gaps in coverage and reimbursement, ... issued the State Telemedicine Gaps Reports last September, many ... laws and regulations impact healthcare delivery in their state,” ... of state actions across the nation, ATA reevaluated the ...
Breaking Medicine News(10 mins):Health News:National Association of Professional Women Inducts Elizabeth Moncada, Owner, Moncada Center for Orofacial Pain, into its 2015-2016 VIP Woman of the Year Circle 2Health News:Global Vision to Spotlight Proofware at INFO*FLEX 2015 2Health News:New UC Davis Program Targets Next Generation of Physicians to Advance Latino Health 2Health News:New UC Davis Program Targets Next Generation of Physicians to Advance Latino Health 3Health News:New UC Davis Program Targets Next Generation of Physicians to Advance Latino Health 4Health News:New UC Davis Program Targets Next Generation of Physicians to Advance Latino Health 5Health News:AJMC’s ACO Coalition Explores the New Rules of Patient Engagement 2Health News:AJMC’s ACO Coalition Explores the New Rules of Patient Engagement 3Health News:AJMC’s ACO Coalition Explores the New Rules of Patient Engagement 4Health News:American Telemedicine Association Delivers New State Report Cards on Telemedicine 2Health News:American Telemedicine Association Delivers New State Report Cards on Telemedicine 3
... Nielsen Company , a leading global information and media company ... advertising and design competitions, announced today that the first-ever ... at www.CLIOHealthcare.com . The submission deadline is August ... June 30, 2009. , , "We are looking forward to ...
... psychiatrists and psychologists from The Child Study Center at NYU ... parents face today , , Expert advice and tips ... disorders, depression, anxiety, homosexuality and more explored on marathon of Doctor ... 1 SIRIUS XM Radio (Nasdaq: SIRI ) today ...
... pilot prevention program targeting fifth graders and their younger ... on Drug Abuse as part of the National Institutes ... award is for two years. The program aims ... and thereby decrease risky behavior and use of drugs ...
... determined that movie characters who smoke, regardless of whether they ... smoking. The study, published in the July 2009 issue of ... Matters More, Good Guys or Bad Guys?" "Previous studies ... initiation of smoking by adolescents, and we wanted to dig ...
... for Dedication to Improving Animal Health and Well-Being , ... for the third annual Thank Your Vet for a ... The national short-essay contest honors America,s veterinarians for their ... have with our pets. The nationwide essay contest runs ...
... National Alliance on Mental Illness (NAMI) reminds Americans that July ... a time for public education about serious mental illness in ... House of Representatives designated July as Bebe Moore Campbell National ... African American novelist and journalist, who also was a voice ...
Cached Medicine News:Health News:Nielsen Announces First-Ever CLIO Healthcare Awards Now Accepting Entries 2Health News:Nielsen Announces First-Ever CLIO Healthcare Awards Now Accepting Entries 3Health News:SIRIUS XM's Doctor Radio to Air July 4th Family Special '24 Hours About Our Kids: Why Kids Behave the Way They Do' 2Health News:SIRIUS XM's Doctor Radio to Air July 4th Family Special '24 Hours About Our Kids: Why Kids Behave the Way They Do' 3Health News:SIRIUS XM's Doctor Radio to Air July 4th Family Special '24 Hours About Our Kids: Why Kids Behave the Way They Do' 4Health News:SIRIUS XM's Doctor Radio to Air July 4th Family Special '24 Hours About Our Kids: Why Kids Behave the Way They Do' 5Health News:SIRIUS XM's Doctor Radio to Air July 4th Family Special '24 Hours About Our Kids: Why Kids Behave the Way They Do' 6Health News:Both good/bad movie characters who smoke influence teens to do the same 2Health News:Search for America's Best Veterinarian Continues With Third Annual 'Thank Your Vet for a Healthy Pet(R)' Contest 2Health News:NAMI Observes Minority Mental Health Awareness Month 2
(Date:5/4/2015)... TAIPEI , May 4, 2015 ... partner, Merrimack Pharmaceuticals, Inc. (NASDAQ: MACK ) ... BAX ) jointly announced that Baxter has ... European Medicines Agency (EMA) for MM-398 (irinotecan liposome ... metastatic adenocarcinoma of the pancreas who have been ...
(Date:5/4/2015)...  Makindus, Inc. a specialty pharmaceutical development company focused ... (EMA) has granted orphan drug designation for their lead ... "We are extremely pleased to now have orphan ... place for Europe . This complements ... United States for which orphan designation has ...
(Date:5/4/2015)... Bayer HealthCare (Bayer) has entered into an ... ISIS ) on ISIS-FXI Rx, an antisense investigational ... Under the agreement Bayer will further develop and commercialize ... need. As part of the clinical development program, Bayer ... in an appropriate patient community. "Bayer ...
Breaking Medicine Technology:PharmaEngine Announces Filing by Baxter BioScience of Marketing Authorization Application of MM-398 (PEP02) to the European Medicines Agency for Post-Gemcitabine Metastatic Pancreatic Cancer Patients 2PharmaEngine Announces Filing by Baxter BioScience of Marketing Authorization Application of MM-398 (PEP02) to the European Medicines Agency for Post-Gemcitabine Metastatic Pancreatic Cancer Patients 3European Medicines Agency (EMA) Grants Orphan Designation for Makindus' MI-100 for Stargardt's Disease 2Bayer Licenses Investigational ISIS FXI(Rx) from Isis Pharmaceuticals to Develop and Commercialize for the Prevention of Thrombosis 2Bayer Licenses Investigational ISIS FXI(Rx) from Isis Pharmaceuticals to Develop and Commercialize for the Prevention of Thrombosis 3
... TechPrecision Corporation (OTC Bulletin Board: ... manufacturer of large-scale, high-precision metal machining fabrications and ... nuclear, defense, aerospace and other commercial industries, today ... purchase order valued at approximately $450,000.  The order, ...
... Inc. today announced that it has expanded its ... gene, CYP2C9, to further support clinicians in prescribing medications ... of the CYP2C9 gene, variations of which can cause ... psychotropic medications, provides physicians with further information on gene ...
Cached Medicine Technology:TechPrecision Corporation Receives New $450,000 Medical Purchase Order 2AssureRx Expands GeneSightRx® Pharmacogenetic Profile with Sixth Gene to Enhance Guidance of Psychiatric Drug Prescribing 2AssureRx Expands GeneSightRx® Pharmacogenetic Profile with Sixth Gene to Enhance Guidance of Psychiatric Drug Prescribing 3
PVC Sealing Tape, 100/Box...
Mylar Plate Sealers 100/Box...
OptiTape - Optically Clear sealing tape for OmniUltra PCR plates. 250 sheet roll....
TDX Tape - sealing sheets for polypropylene plates only, 100/PK...
Medicine Products: