Navigation Links
Radiotherapy can cause lasting vascular disease
Date:3/22/2010

For an as yet unknown reason, cancer radiotherapy can increase the risk of cardiovascular disease later in life, a problem that is growing as more and more people survive their cancer diagnosis. New research from Karolinska Institutet now suggests that sustained inflammation induced by post-radiotherapy changes in the gene expression in the arteries could be the cause.

Epidemiological studies have shown that a course of radiotherapy increases the risk of cardiovascular disease in the same part of the body; for example, myocardial infarction after left-side breast cancer treatment, or stroke after the treatment of head and neck or brain tumours. Scientists know very little, however, about the biological causes of these serious side-effects, which often do not appear until many years following treatment.

"Studies have been hampered by the fact that the disease process is so slow," says Martin Halle, researcher at Karolinska Institutet. "Cell studies and animal studies are best suited to the more immediate effects, and studies on human subjects have been ruled out for ethical reasons."

By studying autografts that have been carried out after cancer, Martin Halle and colleagues have now for the first time managed to study the long-term effects of radiotherapy on human blood vessels. This type of autograft involves the transplantation of skin, muscle or bone tissue from one part of a patient's body to reconstruct defects that arise after the removal of a tumour in another, often irradiated, part. By harvesting biopsies from previously irradiated branches of the carotid arteries and non-irradiated arteries from grafts, the researchers have been able to compare the difference in global gene expression between irradiated and non-irradiated arteries from the same patient at the same time.

They found that the irradiated arteries showed signs of chronic inflammation and an increase in activity of Nuclear Factor- kappaB (NF-kappaB), a t
'/>"/>

Contact: Katarina Sternudd
katarina.sternudd@ki.se
46-852-483-895
Karolinska Institutet
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Patients with resectable esophageal adenocarcinoma benefit from neoadjuvant chemoradiotherapy
2. Split-course palliative radiotherapy confirmed as effective treatment for advanced NSCLC
3. Roseville Radiation Oncology Center (ROC) Redefines Efficiency With Elekta VMAT Radiotherapy Treatments
4. Casual Sex Doesnt Cause Emotional Damage: Study
5. Doctors miss major cause of infertility and obesity
6. Herbal Remedies Can Cause Cardiac Problems
7. No Surprise to David Perecman And Other Personal Injury Attorneys, Vehicles Lead All Causes of Injury at New York Hospital
8. Mental illnesses are second leading cause of time off work in Spain
9. Tobacco Toxin Helps a Protein Cause Lung Cancer
10. How sunlight causes skin cells to turn cancerous
11. Evolving Strains of HIV May Cause Wave of Drug Resistance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... CA (PRWEB) July 29, 2014 Oxnard ... the Anacapa Dental Art Institute in Oxnard and Woodland Hills, ... have fallen out or been removed due to dental disease. ... and the two prosthodontists (experts in restoring and replacing teeth) ... not using implant specialists to perform their dental work and ...
(Date:7/29/2014)... Lean and Lovely, an affordable and short ... want to wear a bikini in the near future. This ... investigative review. , “Our Lean and Lovely review ... all fitness levels. Neither your age nor your body shape ... is at the beginning, you will achieve the results that ...
(Date:7/29/2014)... (PRWEB) July 29, 2014 The ... project, The Cottages at MeadowLands Memory Care, to break ... of those suffering from memory loss and forms of ... has approved the development of Oconto Fall’s first assisted ... Peterson, GM of The Cottages Investment Group, LLC will ...
(Date:7/29/2014)... Couples rule at Maui's only Forbes Five ... This September through November, the focus is on activities and ... of all ages and interests. Best of all, the ... the Resort's popular Experience More package , with resort ... is in full swing in the award-winning restaurants, spa and ...
(Date:7/29/2014)... 2014 Guests at Napa Valley's quintessential luxury ... a new sleep experience. The top of each luxurious resort ... , These expertly crafted, 100% Egyptian cotton white duvets ... distance, yet upon closer look, words are woven in the ... and breathe. , Intentional breathing and visualization are ...
Breaking Medicine News(10 mins):Health News:Oxnard Dental Implant Experts Warn of Infections Around Dental Implants 2Health News:Oxnard Dental Implant Experts Warn of Infections Around Dental Implants 3Health News:Oxnard Dental Implant Experts Warn of Infections Around Dental Implants 4Health News:Lean and Lovely: Review Examining Neghar Fonooni’s Program Released 2Health News:The Cottages Investment Group Announces Third Development Project, The Cottages at MeadowLands Memory Care, Oconto Falls 2Health News:The Cottages Investment Group Announces Third Development Project, The Cottages at MeadowLands Memory Care, Oconto Falls 3Health News:The Cottages Investment Group Announces Third Development Project, The Cottages at MeadowLands Memory Care, Oconto Falls 4Health News:Four Seasons Resort Maui at Wailea Goes All Out to Give Couples Memorable Get-Away this Fall at Maui’s Luxury Resort 2Health News:Four Seasons Resort Maui at Wailea Goes All Out to Give Couples Memorable Get-Away this Fall at Maui’s Luxury Resort 3Health News:Auberge Du Soleil Offers INTENTIONS™ by Peacock Alley on Guests' Beds Providing a Unique Sleep Experience 2
... kits from Beacon Analytical Systems and, ... SoftMax(R), Pro analytical software,SUNNYVALE, CA, Feb. ... innovative solutions for drug discovery and life sciences research, ... Melamine Plate Kit from Beacon Analytical Systems, which focuses ...
... 19 The Providence Service Corporation (Nasdaq: ... been awarded a $1.5 million annual contract to operate ... County, California. The contract is being funded through ... voters as Proposition 63."Our home and community based delivery ...
... Feb. 19 Based on its recent analysis of ... recognizes Horphag Research Ltd. with the 2008 North American ... Award. The award acknowledges the company,s extensive research projects ... at validating the health benefits of the ingredient, Pycnogenol(R), ...
... ST. PETERSBURG, Fla., Feb. 19 Smith & Nephew,s ... SNN ) announced that the United States Patent and ... of KCI,s negative pressure wound therapy (NPWT) patents during ... The Patent Office found that prior art showed ...
... Highlights:- Adjusted EPS from continuing operations of $0.70, ... from continuing operations of $0.65, up 18.3% - ... CVS Caremark Corporation (NYSE: CVS ... earnings for the fourth quarter and year ended ...
... Whether it is due to allergies, gluten intolerance, autism, ... eliminate ingredients such as gluten or milk. Likewise, ... seek relief by using air purifiers and non-toxic cleaning, ... daughters with multiple food and environmental allergies wanted to ...
Cached Medicine News:Health News:MDS Analytical Technologies Announces Validation of Two More Kits for High-Throughput Detection of Melamine in Food 2Health News:MDS Analytical Technologies Announces Validation of Two More Kits for High-Throughput Detection of Melamine in Food 3Health News:MDS Analytical Technologies Announces Validation of Two More Kits for High-Throughput Detection of Melamine in Food 4Health News:Providence Service Corporation California Subsidiary Awarded $1.5 Million Contract Under State's Mental Health Services Act 2Health News:Frost & Sullivan Recognizes Horphag's Pioneering R&D Efforts in Health Ingredients 2Health News:Frost & Sullivan Recognizes Horphag's Pioneering R&D Efforts in Health Ingredients 3Health News:Frost & Sullivan Recognizes Horphag's Pioneering R&D Efforts in Health Ingredients 4Health News:United States Patent Office Rejects KCI's Patents 2Health News:United States Patent Office Rejects KCI's Patents 3Health News:CVS Caremark Reports Record Results in Fourth Quarter and Year 2008 2Health News:CVS Caremark Reports Record Results in Fourth Quarter and Year 2008 3Health News:CVS Caremark Reports Record Results in Fourth Quarter and Year 2008 4Health News:CVS Caremark Reports Record Results in Fourth Quarter and Year 2008 5Health News:CVS Caremark Reports Record Results in Fourth Quarter and Year 2008 6Health News:CVS Caremark Reports Record Results in Fourth Quarter and Year 2008 7Health News:CVS Caremark Reports Record Results in Fourth Quarter and Year 2008 8Health News:CVS Caremark Reports Record Results in Fourth Quarter and Year 2008 9Health News:CVS Caremark Reports Record Results in Fourth Quarter and Year 2008 10Health News:CVS Caremark Reports Record Results in Fourth Quarter and Year 2008 11Health News:CVS Caremark Reports Record Results in Fourth Quarter and Year 2008 12Health News:CVS Caremark Reports Record Results in Fourth Quarter and Year 2008 13Health News:CVS Caremark Reports Record Results in Fourth Quarter and Year 2008 14Health News:CVS Caremark Reports Record Results in Fourth Quarter and Year 2008 15Health News:CVS Caremark Reports Record Results in Fourth Quarter and Year 2008 16Health News:CVS Caremark Reports Record Results in Fourth Quarter and Year 2008 17Health News:CVS Caremark Reports Record Results in Fourth Quarter and Year 2008 18Health News:CVS Caremark Reports Record Results in Fourth Quarter and Year 2008 19Health News:CVS Caremark Reports Record Results in Fourth Quarter and Year 2008 20Health News:CVS Caremark Reports Record Results in Fourth Quarter and Year 2008 21Health News:CVS Caremark Reports Record Results in Fourth Quarter and Year 2008 22Health News:CVS Caremark Reports Record Results in Fourth Quarter and Year 2008 23Health News:Coming Clean: New Allergy Specialty Store is Land of Plenty for All People With Allergies 2
(Date:7/28/2014)... , July 28, 2014 Reportbuyer.com has ... Global Bone Densitometers Market 2014-2018 ... bone densitometry scan is a special type of X-ray ... bone. It is used primarily to detect osteopenia or ... and the risk of fractures is high. The purpose ...
(Date:7/28/2014)... , July 28, 2014 KaloBios Pharmaceuticals, Inc. ... on the status of the KB001-A development program, including ... KB001-A Collaboration Update ... Sanofi Pasteur to regain all rights to KaloBios, KB001-A ... entered into in 2010 has been terminated. Under that ...
(Date:7/28/2014)... , July 28, 2014  Some 2,500 scientists and ... in Montreal for the largest ... a discipline that draws researchers from fields as far ... as diverse as designing new manufacturing processes to creating ... special time because the United Nations has declared 2014 ...
Breaking Medicine Technology:Global Bone Densitometers Market 2014-2018 2Global Bone Densitometers Market 2014-2018 3Global Bone Densitometers Market 2014-2018 4Global Bone Densitometers Market 2014-2018 5KaloBios Provides Update on KB001-A Partnership and Clinical Status 2KaloBios Provides Update on KB001-A Partnership and Clinical Status 3KaloBios Provides Update on KB001-A Partnership and Clinical Status 4KaloBios Provides Update on KB001-A Partnership and Clinical Status 5KaloBios Provides Update on KB001-A Partnership and Clinical Status 6All About Crystals: Tiny, Giant, from Mars, from Earth's Mantle, in Medicine and in Manufacturing 2All About Crystals: Tiny, Giant, from Mars, from Earth's Mantle, in Medicine and in Manufacturing 3All About Crystals: Tiny, Giant, from Mars, from Earth's Mantle, in Medicine and in Manufacturing 4All About Crystals: Tiny, Giant, from Mars, from Earth's Mantle, in Medicine and in Manufacturing 5All About Crystals: Tiny, Giant, from Mars, from Earth's Mantle, in Medicine and in Manufacturing 6
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: