Navigation Links
Radionuclide treatment against small tumors and metastases
Date:6/16/2011

This release is available in German.

A cancer diagnosis is not necessarily a death sentence. There are now quite a number of possibilities to treat cancer. In addition to radiotherapy and chemotherapy, so-called radionuclide treatment has also become an important component in the fight against the mutated cells. It involves injecting radioactive elements, so-called nuclides, into the patient's circulatory system. Bonded to special molecules which preferentially attach themselves to cancer cells, the nuclides are pumped through the body by the heart until they finally find their target: a cancer cell. Having arrived there, they attach themselves to its cell walls, decay and thus release radiation into their surroundings. This attacks the cancer cells at close range and ideally destroys them.

Lutetium-177 is a nuclide already used for clinical applications. As it decays, fast electrons, so-called beta particles, are generated. In human tissue they have a range of up to 100 micrometers, five times the diameter of a tumor cell. They can therefore also damage healthy tissue in the vicinity. Dr. Silvia Lehenberger, a radiochemist at the TUM, has now succeeded in producing the Terbium-161 nuclide pure enough and in quantities sufficient for therapeutic applications. The nuclide emits not only the beta particles, but also conversion and Auger electrons, which have a range of only 0.5 to 30 micrometers. Their ranges match the size of tumor cells, making them ideal for the treatment of small tumors and metastases. "Moreover, the nuclide has a higher energy content than comparable particles," explains Silvia Lehenberger. "This means smaller doses can be administered to the patient, which in turn means a reduction in the radiation exposure."

Like lutetium or neodymium, which is familiar from high-power magnets, terbium is one of the so-called rare earth metals. The elements of the rare earths are extremely similar in chemical terms. Moreover, the raw material contains impurities which would not be permissible for a clinical application. It was therefore essential to develop suitable separation methods in order to be able to isolate the desired terbium-161 in as pure a state as possible. Coauthor and TUM colleague Christoph Barkhausen played a crucial role in the development of the separation method. The similarity of the rare earth elements also has an advantage, however: The medical application worked out for Lutetium-177 can also be used for Terbium-161.

A cooperation between Silvia Lehenberger and researchers at the Paul Scherrer Institute in Villingen (Switzerland) has already been able to prove the effectiveness of the nuclide on cancer cells in the laboratory. This is only the first step on the road to the final medication, however. It must pass a great many tests before it can be administered to people in hospital.

The researchers produced the Terbium-161 nuclide from Gadolinium-160 by neutron irradiation at the Garching FRM II research neutron source. Terbium-161 is ideal for therapeutic purposes because it has a half-life of only 6.9 days. This has the advantage that, after it has been produced, it can be transported to the clinic where it is to be used without losing much of its activity; it also means that the radiation has already decayed to about one percent of its original value after 50 days.

The work was undertaken as part of a cooperation between Radiochemistry Munich (RCM) at the TUM and the Laboratory for Radiochemistry and Environmental Chemistry and the Center for Radiopharmaceutical Sciences at the Paul Scherrer Institute (Villingen/Switzerland). The Terbium-161 was mainly produced at the neutron source of the Technische Universitaet Muenchen in Garching and additionally at the Institut Laue-Langevin in Grenoble and in the neutron source of the Helmholtz Center Berlin. Lutetium-177 for comparative tests was provided by Isotope Technologies Garching GmbH, which has been providing this nuclide to hospitals for many years for therapeutic purposes.


'/>"/>

Contact: Dr. Andreas Battenberg
battenberg@zv.tum.de
49-892-891-0510
Technische Universitaet Muenchen
Source:Eurekalert  

Related medicine news :

1. Treatment gap leaves many older adults at unnecessary risk of fracture
2. Cooling the brain during sleep may be a natural and effective treatment for insomnia
3. Certain head and neck cancer patients benefit from second round of treatment
4. Treatment for Abuse of Anti-Anxiety Drugs Tripled Over 10 Years
5. Coffee drinking improves hepatitis C treatment response
6. Many patients with advanced cancers get treatments that wont help
7. Surgically shrinking the stomach when conservative weight-loss treatments fail
8. Calorie-burning brown fat is a potential obesity treatment, researchers say
9. Flaxseed Fails as Treatment for Hot Flashes
10. Stem cell treatment may offer option for broken bones that dont heal
11. Anorexic girls have increased bone density after physiological estrogen treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Radionuclide treatment against small tumors and metastases
(Date:6/25/2016)... Montreal, Canada (PRWEB) , ... June 25, 2016 , ... ... the pursuit of success. In terms of the latter, setting the bar too high ... low, risk more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... ... 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out of ... verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers Marcy. ... throw rocks at my other children and say he was going to kill them. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is ... Road To Recovery® program to drive cancer patients to and from their cancer treatments. ... the highest quality of life and ongoing independence. Getting to and from medical ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute ... Dr. Barry M. Weintraub as a prominent plastic surgeon and the network’s newest ... world, and the most handsome men, look naturally attractive. Plastic surgery should be ...
(Date:6/24/2016)... ... ... Venture Construction Group (VCG) sponsors Luke’s Wings 5th ... Woodmont Country Club at 1201 Rockville Pike, Rockville, Maryland, 20852. The event raised ... have been wounded in battle and their families. Venture Construction Group is a 2016 ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Any dentist who has made an implant supported ... Many of them do not even offer this as a ... laboratory costs involved. And those who ARE able to offer ... high cost that the majority of today,s patients would not ... Zadeh , founder of Dental Evolutions Inc. and inventor of ...
(Date:6/23/2016)... , June 23, 2016  In a startling report released today, ... their residents by lacking a comprehensive, proven plan to eliminate prescription ... definitive ranking of how states are tackling the worst drug crisis ... four states – Kentucky , New ... Vermont . Of the 28 failing states, three – ...
(Date:6/23/2016)... Research and Markets has announced the ... 2016 - Forecast to 2022" report to their offering. ... up to date financial data derived from varied research sources ... with potential impact on the market during the next five ... comprises of sub markets, regional and country level analysis. The ...
Breaking Medicine Technology: