Navigation Links
Radiologists identify early brain marker of Alzheimer's disease
Date:9/25/2007

OAK BROOK, Ill. Researchers using functional magnetic resonance imaging (fMRI) have found a new marker which may aid in early diagnosis of Alzheimers disease, according to a study published in the October issue of Radiology.

The findings of this study implicate a potential functional, rather than structural, brain markerseparate from atrophythat may help enhance diagnosis and treatment monitoring of Alzheimers patients, said the studys lead author, Jeffrey R. Petrella, M.D., associate professor of radiology at Duke University Medical Center in Durham, N.C.

Alzheimers disease is a progressive brain disorder characterized by memory loss, confusion, personality or behavioral changes and other symptoms. According to the Alzheimers Association, more than five million Americans currently have Alzheimers disease.

While there is still no cure for the disorder, early diagnosis is crucial so that the patient receives proper treatment.

As new therapies for Alzheimers disease enter the pipeline over the next five years, early diagnosis will become critical for patient selection, Dr. Petrella said. fMRI may play a key role in early diagnosis, when combined with clinical, genetic and other imaging markers.

Among the earliest known changes to the brain in Alzheimers disease are episodic memory deficits and structural changes in the medial temporal lobe (MTL). For the study, Dr. Petrella and colleagues set out to identify brain regions in which changes in activation took place during a memory task and to correlate these changes with the degree of memory impairment present in patients with Alzheimers disease or mild cognitive impairment.

The researchers studied 13 patients with mild Alzheimers disease, 34 patients with mild cognitive impairment and 28 healthy controls. The study group contained 37 men and 38 women with a mean age of 72.9 years. After completing standard neuropsychological testing, the study participants were monitored with fMRI while performing a face-name associative memory task.

While some areas of the brain activate, or turn on their activity, when a person tries to remember something, other areas deactivate, or suppress their activity. Results from this study showed that along the spectrum from healthy people at low risk, to people with mild memory problems, to patients with Alzheimers disease, there was increasingly impaired activation in the MTL, an area of the brain associated with episodic memory that normally turns on during a memory task. More surprising, however, was increasingly impaired deactivation in the posteromedial cortices (PMC), an area recently implicated with personal memory that normally suppresses its activity during a memory task. The magnitude of deactivation in the PMC was closely related to the level of memory impairment in the patients and significantly correlated with their neuropsychological testing scores.

While previous studies have suggested that MTL activation may be a possible marker of Alzheimers, based on the findings, Dr. Petrella and colleagues concluded that, compared to activation in the MTL, deactivation in the PMC may represent a more sensitive marker of early Alzheimers disease.

In other words, the brain not only loses its ability to turn on in certain regions, but also loses its ability to turn off in other regions, and the latter may be a more sensitive marker. These findings give us insight into how the brains memory networks break down, remodel and finally fail as memory impairment ensues, Dr. Petrella said.

The researchers hope that fMRI will eventually help to identify patients at risk for developing Alzheimers disease.

The next step is to conduct a large, multicenter study to see if fMRI can be combined with other imaging and genetic tests to scan for future disease, said study co-author P. Murali Doraiswamy, M.D., chief of the Division of Biological Psychiatry and Alzheimers clinical trial expert at Duke. Much like a negative colonoscopy gives you reassurance, a normal fMRI may, in the future, also offer predictive value.


'/>"/>

Contact: Linda Brooks
media@rsna.org
630-590-7762
Radiological Society of North America
Source:Eurekalert

Related medicine news :

1. Radiologists Find New CT Scans Useful
2. Technology-enabled diagnosis by overseas radiologists
3. Computer Software Less Reliable Than Radiologists Eyes in Detecting Cancerous Tumors
4. Laboratory Testing Can Identify Risk of Pre-Term Labor and Delivery
5. Now you can identify Sperm and Egg donors
6. Identifying Predictors Of Anthrax
7. Identifying The Risks Of Developing Schizophrenia
8. Researchers identify the early makers of Neonatal Sepsis
9. Researchers Identify Gene Connected To Bipolar Disorder
10. Blood test may identify ovarian cancer
11. Identifying bacteria made amiable
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... BASKING RIDGE, N.J. (PRWEB) , ... October 13, 2017 , ... ... second annual Holly Day Market. Featuring a collection of specialty vendors and unique items ... myriad of personalized and quality-focused health and wellness services offered by the VNA. ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Yisrayl Hawkins, ... week that explains one of the most popular and least understood books in the ... cryptic and puzzling descriptions that have baffled scholars for centuries. Many have tossed it ...
(Date:10/13/2017)... ... ... “The Journey: From the Mountains to the Mission Field”: the story of a ... “The Journey: From the Mountains to the Mission Field” is the creation of published ... all ages and currently teaches a class of ladies at her church, which she ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... treating sleep apnea using cutting-edge Oventus O2Vent technology. As many as ... disorder characterized by frequent cessation in breathing. Oral appliances can offer significant relief ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ... the introduction of an innovative new design of the shoulder pad. The shoulder ... maximum comfort while controlling your pain while using cold therapy. By utilizing ice and ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
(Date:10/2/2017)... Halo Labs announces the European launch of their new low volume, ... 2017 in Cambridge, U.K on October 4th. ... samples with unprecedented speed and sensitivity while using far less sample ... ... system ...
(Date:9/28/2017)... -- Hill-Rom Holdings, Inc. (NYSE: HRC), will host its ... on Friday, November 3, 2017, beginning at 7:00 a.m. ... 8:30 a.m. (CDT) / 9:30 a.m. (EDT). ... and guidance for 2018, Hill-Rom executives will also highlight ... and long-range financial outlook through 2020. ...
Breaking Medicine Technology: