Navigation Links
Radioimmunotherapy deemed safe and effective for lymphoma patients
Date:7/10/2013

Reston, Va. (July 10, 2013) A new treatment option for patients with relapsing follicular, mantle cell and other indolent B-cell lymphomas has been determined safe and feasible by researchers exploring the potential of a low energy beta-emitter radiopharmaceutical. According to data published in the July issue of The Journal of Nuclear Medicine, the use of 177Lu-DOTA-rituximab as a radioimmunotherapy results in a high rate of tumor response while using less radiation than current therapies.

"Twelve years ago, when we started the study, it seemed that radioimmunotherapy could be a highly interesting tool that was both easy for clinicians to use and well-tolerated in patients. It also was clear that the use of iodine radionuclides was inconvenient for handling and not practical for patients because of the need for prolonged in hospital days due to radiation protection measures," said Andreas Lohri, MD, lead author of the study "Radioimmunotherapy with 177Lu-DOTA-Rituximab: Final Results of a Phase I/II Study in 31 Patients with Relapsing Follicular, Mantle Cell, and Other Indolent B-Cell Lymphomas." "Although 90Y ibritumomab tiuxetanZevalinwas introduced shortly after we started the study, we felt it was important to do clinical experiments with other radionuclides."

The prospective study included 31 patients with histologically confirmed relapsed or refractory CD20-positive B-cell lymphoma. All patients received an initial dose of 740 MBq/m2 body surface area of 177Lu-DOTA rituximab.. Doses were increased in steps of 185 MBq/m2 over a maximum of seven doses. Hematologic and nonhematologic toxicity was measured weekly up to week 10 or until recovery from the lowest level of blood cell count. Imaging with whole body computed tomography (CT) and 18F-FDG positron emission tomography (PET) or 18F-FDG PET/CT was conducted at baseline and at 8-12 weeks.

The maximum tolerated dose using 177Lu-DOTA rituximab was 1,665 MBq/m2. Toxici
'/>"/>

Contact: Susan Martonik
smartonik@snmmi.org
703-652-6773
Society of Nuclear Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Radioimmunotherapy could extend lives of advanced lymphoma patients
2. Talk Therapy Can Ease Depression, But No Single Type Deemed Best
3. Airports in N.Y., L.A., Hawaii Deemed Worst for Pandemic Spread
4. Study shows SBRT for stage I NSCLC safe and effective
5. New research finds flu shot effective regardless of circulating flu strain
6. Virus combination effective against deadly brain tumor, Moffitt Cancer Center study shows
7. Long-term study reports deep brain stimulation effective for most common hereditary dystonia
8. Effective Environmental Services Launch New Websites to Serve Customers
9. Provant CEO, Heather Provino, Shares Key Insights on Employee Engagement & Effective Incentive Program Design at SHRM
10. Alta White Teeth Whitening System Now Available in New Package for Effective Results at Home
11. Animal thyroid extract as effective as T4 in treating hypothyroidism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... Dr. Shalev is a Texas native, and grew up in ... University of Texas, and graduated with a Bachelors of Business ... lay in dentistry, and she went on to receive a ... Science Center at Houston School of Dentistry. Dr. Shalev practices ... Greater Houston Dental Society, and the Texas Dental Association. ...
(Date:9/17/2014)... ADVOCATE, the premier provider of radiology ... they have been awarded the exclusive billing agreement ... Indiana. , ADVOCATE will deliver a ... suite of billing process software functionality called Experience ... and data quality consistency by ensuring a timely, ...
(Date:9/17/2014)... Pittsburgh, PA (PRWEB) September 17, 2014 ... their exercise - even when they're already practicing or ... I was inspired to design a special fitness system ... or playing baseball or football," said an inventor from ... the MOBILITY FITNESS SYSTEM, which maximizes a body workout ...
(Date:9/17/2014)... announced today that will analyze how changes in ... contribute to healthy aging. , Conducted by ... a $10 million unrestricted gift from the Amway ... identify lifestyle and environmental factors that may help ... age. WELL will be designed, conducted, and analyzed ...
(Date:9/17/2014)... chromosomes could hold the key to a better understanding of ... according to new research from the University of Leeds. ... factor for melanoma. , It is well known that pigmentation ... at risk of developing melanoma. For example, paler people should ... easily. , It now appears that another risk factor is ...
Breaking Medicine News(10 mins):Health News:ADVOCATE Wins Radiology Billing Agreements with Fort Wayne Radiology 2Health News:ADVOCATE Wins Radiology Billing Agreements with Fort Wayne Radiology 3Health News:First-ever research study examines impacts of diet and lifestyle on healthy aging 2Health News:Chromosome buffers hold key to better melanoma understanding 2
... IVIG worked. Its ability to treat autoimmune diseases seemed ... immunoglobulin (IVIG) is a complex mixture of IgG antibodies ... from thousands of people, and is only FDA-approved to ... it off-label with varied success in patients with lupus, ...
... geographic convenience and the quality of services that can ... to an article// in the latest edition of the ... a developing trend towards urban centralisation of surgical services, ... care standards. ,However, this creates geographical distances ...
... The Public Works and Government Services Canada said that there ... programs this year.// ,The vaccine instead of being ... in the month of November. Dr. Sheela Basrur, Ontario's chief ... by the beginning of the flu season. Public Works buys ...
... a study conducted by Prof Bernard a senior lecturer at ... found that more number// of rural people of heart attacks ... ,Statistics show that heart disease mortality rates in rural areas ... in women than in urban areas. But the solution to ...
... Australians who have type 2 diabetes could also be at ... the latest issue of the Medical Journal of Australia.// ... Renal Impairment cO-existing with NIDDM (non-insulin dependent diabetes mellitus) - ... ever undertaken in Australian general practice. ,NEFRON examined ...
... A study in Britain has found that nearly one-third of ... purpose, due to rupture, or simply slipping off// during sex, ... ,NOP world undertook a survey of nearly 497 people for ... nearly 64% were groping in the dark about the reasons ...
Cached Medicine News:Health News:Single Sugar Enables Antibody to Treat Inflammation 2Health News:Single Sugar Enables Antibody to Treat Inflammation 3Health News:Bolster Rural Surgical Services 2
(Date:9/17/2014)... DALLAS , September 17, 2014 ... Electronics Market by Component (Sensor, Battery, Memory Device, Display, ... and Fitness & Wellness), and by Geography - Global ... of medical electronics market is expected to reach $56.50 ... from 2014 to 2020. Browse 235 market ...
(Date:9/17/2014)... , Sept. 17, 2014  NuView Life Sciences, ... licensing and collaboration agreement with Otsuka Pharmaceutical Co., ... investigative genomic-based diagnostic biomarker to detect cancers of ... all other future diagnostic-imaging applications. NuView retains all ... delivery and in-vitro urine screen applications. ...
(Date:9/17/2014)... 17, 2014 Isis Pharmaceuticals, Inc. (NASDAQ: ... earned a $4 million milestone payment from Achaogen, ... the initiation of a Phase 3 study of ... gram-negative bacterial infections.  The Phase 3 study is ... efficacy and safety of plazomicin compared to colistin ...
Breaking Medicine Technology:Medical Electronics Market Worth $56.50 Billion by 2020 2Medical Electronics Market Worth $56.50 Billion by 2020 3Medical Electronics Market Worth $56.50 Billion by 2020 4NuView Life Sciences Enters Global Licensing Agreement With Otsuka Pharmaceutical 2NuView Life Sciences Enters Global Licensing Agreement With Otsuka Pharmaceutical 3NuView Life Sciences Enters Global Licensing Agreement With Otsuka Pharmaceutical 4NuView Life Sciences Enters Global Licensing Agreement With Otsuka Pharmaceutical 5Isis Pharmaceuticals Earns $4 Million from Achaogen for the Initiation of a Phase 3 Study of Plazomicin 2Isis Pharmaceuticals Earns $4 Million from Achaogen for the Initiation of a Phase 3 Study of Plazomicin 3
... 2011 Promax Applications Group ( www.promaxtpo.com ), ... and optimization solutions, today announced that Kimberly-Clark Corporation ... Trade Promotion Management (TPM) and Optimization (TPO) solution ... the world,s most recognized consumer brands sold in ...
... Va., March 1, 2011 Health Diagnostic Laboratory ... its partnership to develop a novel laboratory developed ... venture developing diagnostic test and surgical therapy solutions ... disease (CVD), coronary heart disease (CHD) and stroke ...
Cached Medicine Technology:Kimberly-Clark Corporation Selects Promax as its North America Trade Promotion Management and Optimization Solution Provider 2Health Diagnostic Laboratory, Inc. (HDL, Inc.) Partners With Gamma Therapeutics to Offer Breakthrough Diagnostic Assay for Heart Attack and Stroke Risk 2Health Diagnostic Laboratory, Inc. (HDL, Inc.) Partners With Gamma Therapeutics to Offer Breakthrough Diagnostic Assay for Heart Attack and Stroke Risk 3
... is a rapid latex agglutination ... of Helicobacter pylori total antibodies ... in the diagnosis of infection ... is intended for use to ...
... capillary electrophoresis system is designed to ... The CAPILLARYS 2 utilizes liquid flow ... diagnostic setting. Through continuous sample feed ... narrow capillary tubes functioning concurrently, a ...
Inquire...
These Iron Control Slides make an excellent addition to your laboratory. Packed ten (10) control slides per box. Use SDL's Snap n' Stain for Iron Staining Kit alongside to save time an money mixing r...
Medicine Products: