Navigation Links
Radiofrequency treatment better than ethanol injection for small liver tumors

A new review of four randomized controlled trials that directly compared two different treatments for small inoperable liver tumors has found that radiofrequency ablation (RFA) significantly improves patient survival compared to the standard therapy of percutaneous ethanol injection (PEI). These findings are in the February issue of Hepatology, a journal published by John Wiley & Sons on behalf of the American Association for the Study of Liver Diseases (AASLD). The article is also available online at Wiley Interscience (

AASLD guidelines recommend PEI as a safe and highly effective treatment for small hepatocellular carcinomas and say it is the standard against which new therapies should be compared. RFA is one of a handful of alternative nonsurgical treatments for small liver tumors. It has a higher rate of adverse events and is not always usable depending on the location of the tumor, however, some studies have suggested it offers a greater survival benefit compared to PEI.

To determine the benefit of RFA compared to PEI, researchers led by Yun Ku Cho of Seoul conducted a systematic review and meta-analysis of randomized controlled trials that compared the two therapies. Using databases and manual searches, they identified all relevant, peer-reviewed studies published from 1978 through July 2008. Ultimately, only four studies, which included a total of 652 patients, contained enough information for a meta-analysis of three-year overall survival.

"Most randomized controlled trials identified definite survival benefit favoring RFA compared to PEI except the latest trial published in 2008," the authors note. Their meta-analysis also detected a significant improvement in three-year survival for patients who'd undergone RFA.

"The additional survival benefit of RFA can be attributed to improved local tumor response of RFA, which in turn can be explained by the fact that more predictable tumor ablation was possible," the authors suggest. While injected ethanol might be stopped by the liver's fibrous septum or by satellite nodules, the heat from the radiofrequency electrode tip is distributed more homogenously.


Contact: Sean Wagner

Related medicine news :

1. Radiofrequency ablation is effective treatment for dysplasia in Barretts esophagus
2. Three-Quarters of Americans Believe Health Insurance Should Pay for Addiction Treatment, Yet Most Dont Know If Their Health Plan Covers Substance-Abuse Care, Says New Hazelden Survey
3. Growth hormone treatment after weight loss surgery prevents loss of muscle mass
4. UCLA scientists develop crystal ball for personalized cancer treatment
5. Rare skin tumor responds better to treatment than melanoma
6. Less Than Two-Thirds of Surveyed Pharmacy Directors Expect to Reimburse Both Onglyza and Alogliptin Once They are Available for the Treatment of Type 2 Diabetes
7. Top Belgian Cancer Center Becomes First in Country to Introduce RapidArc Radiotherapy Treatments From Varian Medical Systems
8. Aggressive Treatment Effective in Kids Brain Cancer
9. The American Academy of Periodontology issues statement on periodontal treatment during pregnancy
10. GlaxoSmithKline and Genmab Submit Arzerra(TM) (Ofatumumab) Application to FDA for the Treatment of Advanced Stage Blood Cancer
11. Under-Treatment of Pain Exacerbated by Public Perceptions of Medicines and Safety
Post Your Comments:
(Date:11/27/2015)... , ... November 27, 2015 , ... ... center software Q-Suite, announces the incorporation of Asterisk 11 LTS (Long Term Support) ... supported Asterisk 11 LTS brings Q-Suite 5.10 up-to-date with a version of Asterisk ...
(Date:11/26/2015)... ... November 26, 2015 , ... Inevitably when people think Thanksgiving, they also ... buy during the Black Friday and Cyber Monday massage chair sales to ... Internet high and low to find the best massage chair deals, they can see ...
(Date:11/26/2015)... , ... November 26, 2015 , ... ... Express Travel Representative. As a franchise owner, Somu now offers travelers, value and ... destination wedding packages, private cruise sales, as well as, cabin upgrades and special ...
(Date:11/26/2015)... NE (PRWEB) , ... November 26, 2015 , ... Jobs ... searched by healthcare professionals and offered by healthcare staffing agency Aureus Medical Group ... during the month of October 2015 among those searching for healthcare jobs through the ...
(Date:11/26/2015)... (PRWEB) , ... November 26, 2015 , ... ... second medical opinion process, participated in the 61st annual Employee Benefits Conference. The ... and took place Sunday, November 8th through Wednesday, November 11th, 2015. The conference ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... november 2015 AAIPharma Services Corp./Cambridge ... investering aan van ten minste $15,8 miljoen ... het mondiale hoofdkantoor in Wilmington, ... in extra kantoorruimte en extra capaciteit voor ... behoeften van de farmaceutische en biotechnologische markten. ...
(Date:11/26/2015)... --> --> Juntendo University ... contrast weighting of MRI for patients with Multiple Sclerosis ... agreement with SyntheticMR in order to use SyMRI in clinical ... to generate multiple contrast images from a single scan and ... making it possible to both fine tune images and recreate ...
(Date:11/26/2015)... 26, 2015 Research and Markets ( ... "2016 Future Horizons and Growth Strategies in ... Shares, Country Segment Forecasts, Competitive Intelligence, Emerging Opportunities" ... --> --> This new ... Japanese therapeutic drug monitoring market, including emerging tests, ...
Breaking Medicine Technology: