Navigation Links
Radiofrequency ablation is effective treatment for dysplasia in Barrett's esophagus

Interim results from a nationwide clinical trial led by a University of North Carolina at Chapel Hill researcher suggest that radiofrequency ablation is an effective treatment for dysplasia in people with Barretts esophagus, a condition that can lead to deadly gastrointestinal cancer.

The interim results show there is a substantial difference between treatment with radiofrequency ablation and a placebo or sham treatment, said Dr. Nicholas Shaheen, principal investigator of the study and director of UNCs Center for Esophageal Diseases and Swallowing. Its a strongly positive finding.

Shaheen, who is also an associate professor of medicine and epidemiology in UNCs Schools of Medicine and Public Health, presented the results Monday, May 19 at the annual Digestive Disease Week meeting in San Diego.

Barretts esophagus is a condition in which repeated acid reflux causes the cells that normally line the esophagus to be replaced by a different type of cell, similar to those normally found in the intestines. This process is called intestinal metaplasia. By itself Barretts is not a life-threatening problem, but a small percentage of people with Barretts will develop esophageal adenocarcinoma, an especially deadly form of cancer.

Radiofrequency ablation, a non-invasive technique that uses thermal energy, or heat, to destroy cells, is very effective at destroying abnormal cells in the esophagus. The new UNC-led study is the first randomized trial to evaluate radiofrequency ablation for treating dysplasia, a more advanced stage of Barretts esophagus in which the abnormal cells acquire precancerous traits.

The radiofrequency ablation system used in the study uses thermal energy provided by a set of electromagnetic coils on the surface of a balloon, Shaheen said. The balloon is placed in the area of the esophagus where the offending cells are and the balloon is inflated. Energy is then passed through the electromagnetic coils and, because we know how far apart the coils are spaced and how much energy is being put through them, we get a very reliable depth of burn, such that you can kill the abnormal cells on the inner surface without damaging the whole organ.

In the study to date, 127 people were randomized to receive either radiofrequency ablation or a simulated, sham version of the procedure at one of 19 participating medical centers. Among those who received radiofrequency ablation, 85 percent were free of dysplasia 12 months after treatment. Seventy-four percent had no evidence of Barretts at all in their biopsies. In comparison, none that received sham treatment were free of Barretts.


Contact: Stephanie Crayton
University of North Carolina at Chapel Hill

Related medicine news :

1. BioForm Medical Acquires Facial Aesthetic Nerve Ablation Technology
2. ATS Medical Announces First Frontiers in Cryoablation Symposium
3. AtriCures Coolrail(TM) Linear Ablation Pen Receives FDA 510(k) Clearance
4. St. Davids Medical Center First in Texas to Implement Visually Guided Catheter Ablation for Atrial Fibrillation
5. MedWaves, Inc. Announces Receipt of United States Food and Drug Administration 510k Clearance to Market Its Patented Microwave Coagulation/Ablation System
6. Speedy Procedures Demonstrate Excitement and Continued Interest in Novel Multi-Electrode Ablation System
7. Endocare Announces That National Cancer Institute to Sponsor Study Comparing Cryoablation to Radiation Therapy for Pain Relief in Bone Cancer Patients
8. Cryoablation continues to show good results for kidney cancer patients
9. Medicare Sets Physician Payment Rate for Percutaneous Kidney Cryoablation
10. Medicare Increases 2008 Hospital Reimbursement Rates for Cryoablation Treatments of Prostate Cancer
11. New Study Data Published in British Journal of Urology Demonstrates Cryoablation Effective for Kidney Cancer
Post Your Comments:
(Date:10/12/2017)... ... October 12, 2017 , ... Dr. Parsa Mohebi, the Los ... article to the newly revamped Cosmetic Town journal section, featuring articles ... procedure known as Follicular Unit Extraction (FUE). , Dr. Mohebi says ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... Leading pediatric ... peers in Washington, D.C., for the 49th Congress of the International Society of ... Vice President of the Center for Cancer and Blood Disorders at Children’s ...
(Date:10/12/2017)... ... October 12, 2017 , ... Women-owned ... Michigan’s 2017 Best and Brightest in Wellness® by Best and Brightest. OnSite Wellness ... on Friday, Oct. 20 from 7:30 a.m. to 2 p.m. at the Henry ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... property taxes a year. In some states—like New York, New Jersey, Massachusetts, Texas, ... many overseas retirement havens have extremely low property-tax rates, which contributes to the ...
(Date:10/12/2017)... ... October 12, 2017 , ... Farm ... California Berkeley, and other leading institutions in announcing the launch of the ... change the way animals are raised for food. , Founding members of the ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... 2017 AVACEN Medical (AVACEN) announced that its ... helping those with the widespread pain associated with fibromyalgia ... in Essex, England commented, "I ... experiencing no sleep at all, tremendous pain, with every ... recommend [the AVACEN 100] enough, how this has and ...
(Date:9/18/2017)... , Pa. and KALAMAZOO, Mich. , ... Allentown, Penn. , and OptiMed Specialty Pharmacy of ... business partnership to offer a strategic hub service that ... Healthcare,s highly sought-after personal spirometer, Spiro PD 2.0, and ... A spirometer is a medical device used to ...
(Date:9/12/2017)... NEW YORK , Sept. 12, 2017   EcoVadis ... global supply chains, has published the first annual edition of its Global ... more than 20,400 companies evaluated by EcoVadis, based on Scorecard Ratings that ... ... Risk & Performance Index ...
Breaking Medicine Technology: