Navigation Links
Radioembolization improves chance of survival for liver cancer patients

Analysis revealed survival for patients with hepatocellular carcinoma (HCC) is achievable using 90Y-resin microsphere radioembolization. The analysis conducted at multiple centers across Europe showed that the procedure is likely to provide survival benefit across different tumor stages, including patients with advanced liver cancer and with limited treatment options. Findings of the studythe largest to dateare published in the September issue of Hepatology, a journal of the American Association for the Study of Liver Diseases.

According to the World Health Organization (WHO), nearly 700,000 deaths worldwide were attributed to HCC in 2008, with over 80% of these cases resulting from hepatitis B and C infections. Studies have shown an increased incidence of liver cancer including in developed countries, such as the U.S., and the disease is also affecting younger individuals. This year alone, the National Cancer Institute estimates there were more than 26,000 new cases of liver and bile duct cancer in the U.S., with close to 20,000 deaths attributed to the diseases.

"Hepatologists make decisions on treatment based upon the patient's underlying disease as well as tumor stage, taking into account whether tumor progression or advanced cirrhosis is more life-threatening," explains Bruno Sangro, MD, PhD, at the Clinica Universitaria de Navarra in Pamplona, Spain. "Patients with the disease confined to the liver, but who are not eligible for resection or transplantation need liver-directed therapies that reduce tumor burden, relieve symptoms and increase survival."

The current study evaluated the survival benefit of the liver-directed therapy, radioembolization, in 325 patients with HCC at eight European centers. Most patients received a single administration of microspheres with roughly 6% having two and 0.9% having three treatments between September 2003 and December 2009. The median activity of administered treatment was 1.6 GBq with approximately 45% of patients having whole liver and 39% having right-lobe infusions.

Of the HCC patients included in the analysis, 83% were Child-Pugh class A, 79% had underlying cirrhosis, and 88% had a good Eastern Oncology Group (ECOG) performance status. To measure the extent of HCC and liver function, researchers used the Barcelona Clinic Liver Cancer (BCLC) staging system; more than half of the patients were classified as advanced (BCLC C) and a quarter were intermediate (BCLC B) stage.

Results of the analysis showed that median overall survival with radioembolization was close to 13 months. Survival rates ranged depending upon BCLC class with those having less progressed disease and liver involvement (BCLC A) surviving 24 months, BCLC B at close to 17 months and BCLC C patients at 10 months. Researchers noted that the most significant factors affecting prognosis were ECOG performance status, tumor burden, coagulation test score (INR greater than 1.2), and disease outside the liver.

The team reported that the most common adverse events with radioembolization were fatigue, nausea, vomiting, and abdominal pain. Rates for all-cause mortality in this high-risk patient group were 0.6% and roughly 7% at 30 and 90 days, respectively. "Our findings show strong evidence of the survival benefit with radioembolization, even in patients with advanced disease who have few treatments options," concluded Dr. Sangro. "Further study of the procedure in patients with advanced disease is warranted."


Contact: Dawn Peters

Related medicine news :

1. Y-90 radioembolization offers promise for late-stage liver cancer
2. IMRT improves outcomes in patients with extranodal lymphoma of the head and neck
3. Pharmacist-directed anticoagulation service improves care coordination
4. Deep Brain Stimulation Improves Parkinsons Symptoms Long-Term
5. Weight loss improves sexual health of overweight men with diabetes
6. Hospice improves care for dementia patients and their families
7. Elimination of national kidney allocation policy improves minority access to transplants
8. Drug improves brain function in condition that leads to Alzheimers
9. For Some Prostate Cancer Patients, Combo Treatment Improves Survival
10. Arthroscopic treatment of common hip problem improves range of motion
11. Medicaid Coverage Substantially Improves Access to Care: Study
Post Your Comments:
(Date:11/27/2015)... CA (PRWEB) , ... November 27, 2015 , ... According ... carried out by the University of Toronto and the University of British Columbia suggested ... hospitalizations for head injuries. The article explains that part of the reason for the ...
(Date:11/27/2015)... ... November 27, 2015 , ... An inventor, from Hopkinsville, ... prescription medications at home, so he invented the patent-pending ELECTRONIC M.D. , The ... medications. In doing so, it could help to prevent potential overdose situations. As ...
(Date:11/27/2015)... Aliso Viejo, CA (PRWEB) , ... November 27, 2015 , ... ... exclusively for use in Final Cut Pro X. With ProSidebar: Fasion, video editors ... banners, or use ProSidebar as a minimalist title opener. Utilize presets featuring self-animating ...
(Date:11/27/2015)... ... November 27, 2015 , ... A simply groundbreaking television series, ... interesting show that delves into an array of issues that are presently affecting Americans. ... from open dialogue, this show is changing the subjects consumers focus on, one episode ...
(Date:11/27/2015)... , ... November 27, 2015 , ... ... largest, most successful and prominent nonprofit healthcare organizations in the country. They have ... with various organizations, and helped advance the healthcare industry as a whole through ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... , Nov. 26, 2015  The total global healthcare ... 7% over 2015-2016. Latin America has ... , (excluding Japan ), is second ... continues to face increased healthcare expenditure. In 2013-2014, total ... declined from 43.5% in 2008-2009 to 41.2% in 2013-2014. In ...
(Date:11/25/2015)...  Linden Care, LLC, a retail specialty pharmacy focused ... suffering from chronic pain, said today that it is ... (TRO) enjoining Express Scripts from unilaterally terminating the Pharmacy ... --> --> The company said that ... --> --> In ...
(Date:11/25/2015)... Nov. 25, 2015  ARKRAY USA ... to provide evidence demonstrating the accuracy of its blood ... on Insulin Resistance, Diabetes and Cardiovascular Disease in ... the Company,s GLUCOCARD ® 01 meter and the ... requirements. The ability to accurately measure glucose levels in ...
Breaking Medicine Technology: