Navigation Links
Radiation treatment after surgery improves survival for elderly women with early-stage breast cancer
Date:10/30/2012

BOSTON, Mass. Oct. 29, 2012. Elderly women with early-stage breast cancer live longer with radiation therapy and surgery compared with surgery alone, researchers at the University of Maryland School of Medicine have found. The researchers, who collected data on almost 30,000 women, ages 70 to 84, with early, highly treatable breast cancer enrolled in a nationwide cancer registry, are reporting their findings at the 54th annual meeting of the American Society for Radiation Oncology (ASTRO).

"Overall survival and breast cancer-specific survival were significantly better at all time points for elderly women with Stage I, estrogen-receptor (ER)-positive breast cancer with no lymph node involvement who received radiation therapy following surgery to remove the tumor," says lead author Randi J. Cohen, M.D., M.S., an assistant professor of radiation oncology at the University of Maryland School of Medicine and a physician in the Department of Radiation Oncology at the University of Maryland Marlene and Stewart Greenebaum Cancer Center.

For women who had radiation and a lumpectomy, the overall survival rate was 88.6 percent at five years, 65 percent at 10 years and 39.6 percent at 15 years. That compares with a survival rate of 73.1 percent at five years, 41.7 percent at 10 years and 20 percent at 15 years for women who only had surgery. The median survival was 13 years for patients receiving surgery and radiation, compared with 9.9 years for patients receiving surgery alone. The researchers don't know how many of the women also received hormonal therapy.

"Our findings suggest that adjuvant radiation therapy should be strongly considered as part of the treatment regimen for otherwise healthy elderly women with early ER-positive breast cancer," Dr. Cohen says. "A woman's age alone should not dictate whether or not radiation is recommended."

The senior author, Steven J. Feigenberg, M.D., an associate professor of radiation oncology at the University of Maryland School of Medicine and a researcher at the University of Maryland Greenebaum Cancer Center, notes that the data also showed that the use of adjuvant radiation decreased as the women grew older. Eighty percent of women age 70-74 received radiation compared with 61 percent of women age 80-84.

"Breast radiation is the standard of care following lumpectomy for early-stage breast cancer, but previous research suggested that it helped to prevent the cancer from returning in the treated breast but has no impact on survival in older women," Dr. Feigenberg says. "As a result, some elderly women may not have been offered radiation therapy as part of their breast cancer treatment. We wanted to look at a large, population based database to determine if radiotherapy does offer some benefits in terms of survival, and we found that it does."

Breast cancer patients typically have radiation treatments five days a week for six weeks following surgery, to prevent the cancer from recurring.

E. Albert Reece, M.D., Ph.D., M.B.A., vice president for medical affairs at the University of Maryland and the John Z. and Akiko K. Bowers Distinguished Professor and dean of the University of Maryland School of Medicine, says, "Breast cancer is a very common problem for older women, with more than half of the women diagnosed with breast cancer in the U.S. over the age of 65. Many of them have early-stage cancers, which can removed with a lumpectomy. This large-scale study provides convincing evidence that adjuvant radiation therapy should also be offered to these older patients."

The researchers analyzed data from the SEER (Surveillance, Epidemiology and End Results) registry, which is maintained by the National Cancer Institute. They identified 29,949 women, from 70 to 84 years old, who were diagnosed with early-stage (T1 N0 M0) ER-positive breast cancer between 1990 and 2009 and had limited surgery. Seventy-six percent of the patients also received adjuvant radiation.

The median follow-up was 5.5 years, but the researchers used an analysis tool to determine overall survival and breast cancer-specific survival, which was also improved for patients who had surgery and radiation, the researchers found. At five years, the breast cancer-specific survival rate was 98.3 percent for women who received radiation and surgery compared to 97.4 percent who had surgery alone. At 10 years, the rate was 95.5 percent versus 93.3 percent.

The researchers attributed the improved outcomes with surgery and radiation to better "locoregional control" of the cancer. They also noted that patients selected to receive radiation may have been healthier with a longer anticipated life expectancy than those who did not receive radiation.


'/>"/>

Contact: Karen Warmkessel
kwarmkessel@umm.edu
41-032-889-194-104-041-53
University of Maryland Medical Center
Source:Eurekalert

Related medicine news :

1. Antibody therapy prevents gastrointestinal damage following radiation exposure in mice
2. Diagnostic Scans Tied to Radiation Risk for Gastro Patients
3. CT Scans Deliver More Radiation to Obese People: Study
4. Intensity Modulated Radiation Therapy optimal for localized prostate cancer
5. Study examines adverse effects among different radiation therapies for prostate cancer
6. Chemo + Radiation Best for Bladder Cancer, Study Finds
7. Use of dedicated pediatric imaging departments for pediatric CT reduces radiation dose
8. APBI associated with more mastectomies, toxicities, complications, compared to traditional radiation
9. Cone beam CT proves better for visualizing some causes of hearing loss at half the radiation dose
10. Highly targeted irradiation as good as whole breast radiotherapy in early stage cancer
11. Novel biomarkers reveal evidence of radiation exposure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... ... announced today its affiliation with Tennessee Counseling Association. This new relationship ... of the Tennessee Counseling Association, adding exclusive benefits and promotional offers. , "TCA ...
(Date:6/26/2016)... N.J. (PRWEB) , ... June 27, 2016 , ... Quality ... sources, yet in many ways they remain in the eye of the beholder, according ... (EBO), a publication of The American Journal of Managed Care. For the full issue, ...
(Date:6/26/2016)... ... ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop a weight ... app plans to fix the two major problems leading the fitness industry today:, ... program , They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... Miami, FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton ... Plant City Observer , brings up a new, often overlooked aspect of head lice: ... The closing for fumigation is not a common occurrence, but a necessary one in the ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. ... from injury. Recently, he has implemented orthobiologic procedures as a method for treating ... one of the first doctors to perform the treatment. Orthobiologics are substances that ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016  Global Blood Therapeutics, ... company developing novel therapeutics for the treatment of ... announced the closing of its previously announced underwritten ... at the public offering price of $18.75 per ... were offered by GBT. GBT estimates net proceeds ...
(Date:6/24/2016)... ALEXANDRIA, Va. , June 24, 2016 ... a set of recommendations that would allow ... information (HCEI) with entities that make formulary and coverage ... determine the "value" of new medicines. The ... that does not appear on the drug label, a ...
(Date:6/24/2016)... According to a new market ... Needles, Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, ... of Purchase (Retail, Non-Retail) - Trends & Global Forecasts ... market for the forecast period of 2016 to 2021. ... by 2021 from USD 1.65 Billion in 2016, growing ...
Breaking Medicine Technology: