Navigation Links
Radiation still used despite evidence of little benefit to some older breast cancer patients
Date:3/5/2012

Even though a large clinical study demonstrated that radiation has limited benefit in treating breast cancer in some older women, there was little change in the use of radiation among older women in the Medicare program, Yale School of Medicine researchers report in the March Journal of Clinical Oncology.

"We were surprised by these results," said lead author Cary P. Gross, M.D., associate professor of internal medicine at Yale School of Medicine. "Clinical trials are considered the gold standard of medical research and in this case the trial was influential enough to lead to a change in treatment guidelines. We expected it to have more of an impact on clinical care at the bedside."

The typical course of treatment for older women with early stage breast cancer is breast-conserving surgery followed by radiation therapy. The purpose of added radiation therapy is to reduce recurrence of the disease. However, many older women have less aggressive tumors that place them at low risk for tumor recurrence.

The Yale team studied the impact of a large research trial funded by The National Cancer Institute (NCI) on clinical practice. Published in 2004, that NCI trial found that radiation therapy had only a small benefit for some women 70 and older with early stage, low-risk breast cancer. As a result of this study, breast cancer treatment guidelines were changed to indicate that radiation therapy could be considered optional for such patients.

But in the years following implementation of the new guidelines, Gross and his colleagues found that there has been minimal impact on the clinical care of older women with breast cancer. The team looked at the use of radiation therapy among Medicare beneficiaries diagnosed with early stage breast cancer before and after the large NCI clinical trial was published. About 79% of women received radiation prior to the study compared with 75% after.

Even among the oldest women (85-94 years), the trial appeared to have little effect on clinician practice: The use of radiation decreased from 37% prior to the study to 33% after.

"These findings have important implications for how the results of clinical research studies are translated into practice," said Gross, who points out that the U.S. government invested over $1 billion in comparative effectiveness research as part of the American Recovery and Reinvestment Act of 2009. "Our societal interest in funding this type of research is appropriate, and the need is great, but we must ensure that the results of such research extend beyond the journal page and are actually incorporated into clinical decision-making."


'/>"/>
Contact: Karen N. Peart
203-432-1326
Yale University
Source:Eurekalert

Related medicine news :

1. A new radiotherapy technique significantly reduces irradiation of healthy tissue
2. Oxford University Press to publish open access title Journal of Radiation Research
3. Research finds newer radiation therapy technology improves patients quality of life
4. Radiation plus chemotherapy provides long-term positive results for head and neck cancer patients
5. Cabazitaxel with radiation and hormone therapy may improve prostate cancer survival
6. Experts offer pointers for optimizing radiation dose in pediatric CT
7. Breast Cancer Radiation Linked to Raised Heart Risk
8. Targeted Radiation for Breast Cancer May Be Overused: Study
9. Scientists may be able to double efficacy of radiation therapy
10. Childhood cancer survivors exposure to chemotherapy, radiation does not increase risk of birth defects in their children
11. Blue light irradiation promotes growth, increases antioxidants in lettuce seedlings
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... ... February 12, 2016 , ... Young Asset Protection, a ... beginning of the latest charity campaign in their community enrichment program. Art Expression ... this worthy cause are currently being accepted at: http://artexpressioninc.org/ . , Art ...
(Date:2/12/2016)... ... February 12, 2016 , ... For Coast Dental dentist Everet Lake, ... and dental assistant Terrell Moore shortly before 7 a.m. to volunteer at Friday’s Dentistry ... donating their time and skills to help hundreds of uninsured and underinsured people receive ...
(Date:2/12/2016)... ... February 12, 2016 , ... ... choices that promote eye health. These articles generally list between five and 15 ... advocate Sharon Kleyne endorses every one of these lists and believes that nutritious ...
(Date:2/12/2016)... ... February 12, 2016 , ... US Sport Camps is pleased to announce the ... in Norwalk, serves as the host site and directing the camps is PGA Professional ... had successful camps in recent years around Des Moines and are fortunate to have ...
(Date:2/12/2016)... Calif. (PRWEB) , ... February 12, 2016 , ... The Central Coast Autism Spectrum Center ... dance is to provide a night of fun for teens with and without special needs ... feel welcomed and included at the event. The dance will take place on Saturday, Feb. ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... /PRNewswire/ - Demers Ambulances announces its first delivery in the state ... County Emergency Medical Services (EMS) consisting of four ... van. Quality Emergency Vehicles in Lecanto, FL ... This is the latest in Demers, ongoing expansion of sales.  ... Demers. --> Benoit LaFortune , Executive Vice President ...
(Date:2/12/2016)... 12, 2016 ... http://www.sedar.com ) und der ... abrufbar.    --> http://www.sedar.com ) ... http://www.telestatherapeutics.com abrufbar.    --> ... seinen Konzernabschluss des zweiten Quartals und ...
(Date:2/12/2016)... , Feb. 12, 2016   HeartWare International, ... conference call and webcast to discuss its financial results ... 2015, on Thursday, February 25, 2016 at 8:00 a.m. ... prior to the conference call and webcast.  On the ... financial results, highlights from the fourth quarter and business ...
Breaking Medicine Technology: