Navigation Links
Radiation plus hormone therapy greatly improves survival
Date:11/2/2011

(Toronto Nov. 3, 2011) Men with locally advanced or high-risk prostate cancer who receive combined radiation and hormone therapy live longer and are less likely to die from their disease, shows clinical research led by radiation oncologists at the Princess Margaret Hospital (PMH) Cancer Program, University Health Network.

The findings are published online today in The Lancet (doi: 10.1016/S0140-6736(11)61095-7). Principal investigator Padraig Warde, deputy head, PMH radiation medicine program, says: "The study shows combining radiation and hormone therapy improves overall survival by 23 percent and disease-specific survival by 43 percent, compared with treating with hormone therapy alone.

"Based on these results, we believe adding radiation to the treatment plan should become part of the standard therapy." Dr. Warde is also a Professor in the Department of Radiation Oncology, University of Toronto. (view Dr. Warde video at http://www.youtube.com/watch?v=tC0uJWcrGJg )

Prostate cancer is the most common malignancy in men and between 15% and 25% percent of cases are high risk, says Dr. Warde. The Canadian Cancer Society estimates 25,500 new cases will be diagnosed this year and that 4,100 men will die from the disease.

In the randomized study of 1,205 men to investigate appropriate treatment for high-risk prostate cancer, half the participants received androgen deprivation therapy ("hormone therapy") alone and half received hormone therapy plus radiation.

After seven years, 66 percent of men who had hormone therapy only were still alive, compared with 74 percent who received the combined therapy. Among those in the hormone-only group, 26 percent died from their prostate cancer versus 10 percent who received hormone therapy plus radiation.

"This study will challenge the prevailing dogma of only using hormone therapy alone for locally advanced prostate cancer," says Dr. Warde. "As well, we found the radiation therapy was tolerated well with no significant toxicity."

He believes the benefits of combined therapy could actually be even greater now given the use of more targeted radiation techniques that have been developed since the study began in 1995.

"Our study shows the way to combine existing, effective treatment options that are readily available to improve outcomes for many men with high-risk prostate cancer."

The study, conducted by the NCIC Clinical Trials Group (NCIC CTG) at Queen's University in Kingston, Ontario in collaboration with the Medical Research Council UK involved clinical researchers and staff from participating sites throughout Canada and internationally. Patients were enrolled onto the study between 1995 and 2005.


'/>"/>

Contact: Jane Finlayson
jane.finlayson@uhn.on.ca
416-946-2846
University Health Network
Source:Eurekalert

Related medicine news :

1. FDA Seeks Reduction in Radiation From Medical Scans
2. For Some Breast Cancer Patients, Shorter Radiation Works Well
3. Short-term radiation therapy successful on breast cancer
4. ASCROs Response to NY Times Articles on Radiation Therapy Incidents
5. Imaging manufacturers: Plan to reduce unnecessary radiation exposure and medical errors
6. Roseville Radiation Oncology Center (ROC) Redefines Efficiency With Elekta VMAT Radiotherapy Treatments
7. New cardiac CT technology drastically reduces patient radiation exposure
8. New Heart CT Scans Deliver Far Less Radiation: Study
9. Accelerated radiation therapy reduces toxicity in patients with advanced head and neck cancers
10. Delaying post-surgical radiation increases risk of breast cancer recurrence in older women
11. Radiation Most Effective Soon After Breast Cancer Surgery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... , ... June 27, 2016 , ... ... , the only authorized OSHA Training Institute Education Center headquartered in Northern California, ... their workers from extreme heat at their worksites. Employers with workers exposed ...
(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... "FCPX editors ... customizable inside of Final Cut Pro X," said Christina Austin - CEO of Pixel ... style. Final Cut Pro X users can now reveal the media of ...
(Date:6/27/2016)... ... , ... TherapySites, the leading website and online ... Counseling Association. This new relationship allows TherapySites to continue to extend their ... benefits and promotional offers. , "TCA is extremely excited about this new partnership, ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... payment industry today announced its strategic partnership with Connance, a healthcare industry ... The two companies’ proven, proprietary technology combine to provide health systems, hospitals ...
(Date:6/27/2016)... ... June 27, 2016 , ... A revolution is underway. ... transport experience for the millions of people who require these medical transport services ... industry through the use of technology. Now, SmartEMS has put forth an industry-changing ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 Roche ... received 510(k) clearance for its Elecsys BRAHMS PCT (procalcitonin) ... severe sepsis or septic shock. With this clearance, Roche ... provide a fully integrated solution for sepsis risk assessment ... associated with bacterial infection and PCT levels in blood ...
(Date:6/23/2016)... 2016 Capricor Therapeutics, Inc. ... biotechnology company focused on the discovery, development and ... enrollment in its ongoing randomized HOPE-Duchenne clinical trial ... of its 24-patient target. Capricor expects the trial ... of 2016, and to report top line data ...
(Date:6/23/2016)... Bracket , a leading clinical trial technology and specialty ... Bracket eCOA (SM) 6.0, at the 52 nd ... in Philadelphia , Pennsylvania.  A demonstration of ... its kind to fully integrate with RTSM, will be held ... a flexible platform for electronic clinical outcomes assessments that is ...
Breaking Medicine Technology: