Navigation Links
Radiation pharmacogenomics identifies biomarkers that could personalize cancer treatment
Date:10/4/2010

October 5, 2010 Radiation therapy is used to treat more than half of all cancer cases, but patient response to therapy can vary greatly. Genetics is increasingly being recognized as a significant contributor to inter-individual response to radiation, but the biology underlying response remains poorly understood. In a study published online today in Genome Research (www.genome.org), researchers employed a pharmacogenomics approach to find biomarkers associated with radiation response that could help to more effectively tailor individual cancer treatments in the future.

Response to radiation treatment can range from complete eradication of the tumor to severe adverse reactions in normal tissues that complicate a patient's recovery. Several clinical factors, such as radiation dose and fraction, are known to influence radiation response, but it has recently been estimated that genetic factors may explain nearly 80% of the inter-individual variation of radiation response in normal tissue. If genetic variants and biological mechanisms contributing to radiation response are identified, more personalized treatment strategies could be employed in the clinic.

In this study, researchers led by Liewei Wang of the Mayo Clinic performed a genome-wide association study on 277 ethnically defined human lymphoblastoid cell lines (LCLs) to identify biomarkers for radiation response. Previous studies have found that genetic variation significantly influences gene expression following radiation treatment, however a possible relationship of basal gene expression with radiation response has not been extensively studied until now, and could be key to predicting response. The group integrated several lines of data from the LCLs, including 1.3 million single nucleotide polymorphisms (SNPs), genome-wide gene expression data, and ionizing radiation cytotoxicity phenotypes.

By looking for SNPs and gene expression patterns that associate with a radiation response phenotype, Wang's group narrowed down a list of candidate genes associated with radiation treatment response. To functionally validate the biomarkers, the team tested the associations of a set of the candidate genes in three cancer cell lines. The validation experiments confirmed the expression of five genes as involved in radiation-induced response.

Wang noted that this work not only identifies biomarkers, but also sets the stage for uncovering novel functions of these genes that could ultimately benefit individual patients. "These studies will provide a foundation for future translational studies to individualize radiation therapy based on the expression of these candidate genes," said Wang, "and may make it possible to design novel combination therapy for selected patients based on these biomarkers to overcome resistance."

Scientists from the Mayo Clinic (Rochester, MN) contributed to this study.


'/>"/>

Contact: Peggy Calicchia
calicchi@cshl.edu
516-422-4012
Cold Spring Harbor Laboratory
Source:Eurekalert

Related medicine news :

1. Mayo researchers find biomarkers for personalizing radiation cancer treatment
2. Researcher at Childrens Hospital LA discovers way to overcome radiation resistance in leukemia
3. Novel target for existing drug may improve success of radiation therapy
4. Radiation exposure poses similar risk of first and second cancers in atomic bomb survivors
5. Scientists receive nearly $11 million to develop radiation countermeasures
6. Surgery better than radiation, hormone treatments for some prostate cancer, study shows
7. ASTRO publishes whole breast irradiation guidelines
8. Mayo Clinic researchers share latest findings in CT radiation dose reduction efforts
9. Dose optimization workshop helps reduce radiation dose associated with MDCT scans
10. Radiation for Childhood Cancer Can Boost Risk of Stillbirth Later
11. Video game processors help lower CT scan radiation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... ... May 24, 2016 , ... Educational opportunities, and ... with more advantaged communities providing richer opportunities. Recognizing the key role of housing ... improvement policies; (b) school choice policies; (c) school desegregation policies; (d) wealth-focused policies; ...
(Date:5/24/2016)... Freeport, Grand Bahama (PRWEB) , ... May 24, 2016 , ... ... rapid pace. Such breakthroughs in adult stem cell therapy technology, protocols and patient results ... for this emerging field to become a more accessible standard of care for patients ...
(Date:5/24/2016)... ... May 24, 2016 , ... Backed ... data logger for each job, ensuring the best suited solution to meet regulatory ... data loggers at their lab in Istanbul. , Metroloji Okulu specializes in MadgeTech’s ...
(Date:5/24/2016)... , ... May 24, 2016 , ... ... appointment of Jonathan (Jon) Otterstatter to its board of directors. Otterstatter ... proven leader in the development of technological innovations that lead to broad-based healthcare ...
(Date:5/24/2016)... (PRWEB) , ... May 24, 2016 , ... WaterAid launched the #perioddrama campaign ... by more than 1 billion women around the world who do not have access to ... from across the US about their dread of #perioddrama. The (sometimes hilarious) results help shine ...
Breaking Medicine News(10 mins):
(Date:5/23/2016)... -- Clarifying Vision - Prospects and Developments ... Care What can be expected from the ... at the fastest rates? This visiongain report ... opportunities and prospects. ,Our 190-page report ... lucrative areas in the industry and the future market ...
(Date:5/23/2016)... Gamida Cell, a leader in cellular and ... genetic diseases, announced today it has been awarded a ... Innovation Authority (formerly the Office of the Chief Scientist) ... mission of the Israel Innovation Authority is to encourage ... technology, while stimulating economic growth. The non-dilutive ...
(Date:5/20/2016)... 20, 2016 ReportsnReports.com adds ... Medical Devices of its online business intelligence library. ... the current state of the Titrator industry. The ... like definitions, classifications, Specifications, applications and industry chain ... like Raw Material Suppliers, Equipment Suppliers, Manufacturing Cost ...
Breaking Medicine Technology: