Navigation Links
Radiation pharmacogenomics identifies biomarkers that could personalize cancer treatment
Date:10/4/2010

October 5, 2010 Radiation therapy is used to treat more than half of all cancer cases, but patient response to therapy can vary greatly. Genetics is increasingly being recognized as a significant contributor to inter-individual response to radiation, but the biology underlying response remains poorly understood. In a study published online today in Genome Research (www.genome.org), researchers employed a pharmacogenomics approach to find biomarkers associated with radiation response that could help to more effectively tailor individual cancer treatments in the future.

Response to radiation treatment can range from complete eradication of the tumor to severe adverse reactions in normal tissues that complicate a patient's recovery. Several clinical factors, such as radiation dose and fraction, are known to influence radiation response, but it has recently been estimated that genetic factors may explain nearly 80% of the inter-individual variation of radiation response in normal tissue. If genetic variants and biological mechanisms contributing to radiation response are identified, more personalized treatment strategies could be employed in the clinic.

In this study, researchers led by Liewei Wang of the Mayo Clinic performed a genome-wide association study on 277 ethnically defined human lymphoblastoid cell lines (LCLs) to identify biomarkers for radiation response. Previous studies have found that genetic variation significantly influences gene expression following radiation treatment, however a possible relationship of basal gene expression with radiation response has not been extensively studied until now, and could be key to predicting response. The group integrated several lines of data from the LCLs, including 1.3 million single nucleotide polymorphisms (SNPs), genome-wide gene expression data, and ionizing radiation cytotoxicity phenotypes.

By looking for SNPs and gene expression patterns that associate with a radiation response phenotype, Wang's group narrowed down a list of candidate genes associated with radiation treatment response. To functionally validate the biomarkers, the team tested the associations of a set of the candidate genes in three cancer cell lines. The validation experiments confirmed the expression of five genes as involved in radiation-induced response.

Wang noted that this work not only identifies biomarkers, but also sets the stage for uncovering novel functions of these genes that could ultimately benefit individual patients. "These studies will provide a foundation for future translational studies to individualize radiation therapy based on the expression of these candidate genes," said Wang, "and may make it possible to design novel combination therapy for selected patients based on these biomarkers to overcome resistance."

Scientists from the Mayo Clinic (Rochester, MN) contributed to this study.


'/>"/>

Contact: Peggy Calicchia
calicchi@cshl.edu
516-422-4012
Cold Spring Harbor Laboratory
Source:Eurekalert

Related medicine news :

1. Mayo researchers find biomarkers for personalizing radiation cancer treatment
2. Researcher at Childrens Hospital LA discovers way to overcome radiation resistance in leukemia
3. Novel target for existing drug may improve success of radiation therapy
4. Radiation exposure poses similar risk of first and second cancers in atomic bomb survivors
5. Scientists receive nearly $11 million to develop radiation countermeasures
6. Surgery better than radiation, hormone treatments for some prostate cancer, study shows
7. ASTRO publishes whole breast irradiation guidelines
8. Mayo Clinic researchers share latest findings in CT radiation dose reduction efforts
9. Dose optimization workshop helps reduce radiation dose associated with MDCT scans
10. Radiation for Childhood Cancer Can Boost Risk of Stillbirth Later
11. Video game processors help lower CT scan radiation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2017)... ... August 22, 2017 , ... The ... as a 2017-2018 inductee into its VIP Woman of the Year Circle. She ... nation’s leading networking organization exclusively for professional women, boasting more than 850,000 members, ...
(Date:8/21/2017)... MINNEAPOLIS, MINN (PRWEB) , ... August 21, 2017 ... ... Sports Group, today announced that it has become the Official Technology Partner of ... their AES (Advanced Event Systems) volleyball software, along with providing sport ...
(Date:8/21/2017)... ... August 21, 2017 , ... Duncan ... program serving the people of Michigan. The new initiative fundraises for the Kalamazoo ... the very forefront of animal protection and welfare by addressing the root causes ...
(Date:8/21/2017)... ... ... The American Hospital Association (AHA) has elected Claire Zangerle, Chief Nurse Executive ... of Trustees for a three-year term beginning January 1, 2018. , The ... are committed to the improvement of health in their communities. Founded in 1898, the ...
(Date:8/21/2017)... ... ... The Industrial Designers Society of America (IDSA) hosted the ... Aug. 19, 2017 in Atlanta, GA—revealing which 25 designs won Gold and which 52 ... See all the winners at http://www.idsa.org/awards/idea/gallery . , “I hope you’re as excited ...
Breaking Medicine News(10 mins):
(Date:7/31/2017)... July 31, 2017  Diplomat Pharmacy, Inc. (NYSE: DPLO), has ... Michigan by Crain,s Detroit Business . ... public companies by three-year revenue growth. This year,s edition measures ... To view the complete list, visit crainsdetroit.com/awards/fast_50/2017 .  ... an incredible triumph," said Phil Hagerman , CEO and ...
(Date:7/31/2017)... 31, 2017 7D Surgical, developer of ground breaking ... the 7D Surgical System to support its strategic sales plan ... and Virginia.  7D Surgical has entered into an ... the premier medical facilities within those markets. ... Spartan ...
(Date:7/28/2017)... --EnvoyHealth, a Diplomat company, has partnered with Compliance Meds ... a technology designed to improve patient medication adherence. ... solutions and services that help track and improve patients, ... LITE offers medication monitoring and control for patients and ... Records date and time of bottle ...
Breaking Medicine Technology: