Navigation Links
Radiation exposure poses similar risk of first and second cancers in atomic bomb survivors
Date:9/14/2010

SEATTLE It is well known that exposure to radiation has multiple harmful effects including causing cancer but until now, it has been unclear to what extent such exposure increases a person's risk of developing more than one cancer.

The first large-scale study of the relationship between radiation dose and risk of multiple cancers among atomic bomb survivors in Hiroshima and Nagasaki, Japan reveals a similar risk in the development of first and second subsequent cancers.

Christopher I. Li, M.D., Ph.D., and colleagues at Fred Hutchinson Cancer Research Center led the study in collaboration with investigators at the Radiation Effects Research Foundation in Hiroshima and Nagasaki and the National Cancer Institute. The results appear in the Sept. 15 issue of Cancer Research.

"We found that radiation exposure increased the risks of first and second cancers to a similar degree," said first author Li, a breast cancer epidemiologist and member of the Public Health Sciences Division at the Hutchinson Center. "People exposed to radiation who developed cancer also had a high risk of developing a second cancer, and the risk was similar for both solid tumors and leukemias in both men and women, regardless of age at exposure or duration between first and second primary cancers," he said.

The association between radiation exposure and risk of second cancers was particularly significant for radiation-sensitive cancers, such as those of the lung, colon, breast, thyroid and bladder, as well as leukemia.

For the study, the researchers analyzed data from participants in the Life Span Study, a group of atomic bomb survivors in Hiroshima and Nagasaki who were followed from 1950, five years after the bombings, to 2002, the most recent year through which Hiroshima and Nagasaki cancer registry data were complete. The study followed 10,031 primary cancer survivors, among whom 1,088 went on to develop second primary cancers.

Stomach, lung, liver and female breast cancers were the most commonly diagnosed first and second primary cancers.

"Our findings suggest that cancer survivors with a history of radiation exposure should continue to be carefully monitored for second cancers," Li said.

In addition to clinical implications for cancer patients and others exposed to significant amounts of radiation, such research is essential to developing radiation protection limits and standards for occupational exposures, as well as planning for the consequences of widespread radiation exposure in the general population in the event of a nuclear accident, nuclear war or "dirty bomb" terrorist attack.

"We greatly appreciate having the opportunity to conduct this unique research with our Japanese colleagues who, through innumerable publications, have truly transformed the tragedy of the atomic bombings to fundamental scientific advancements that have impacted radiation protection standards and policies worldwide," Li said.


'/>"/>

Contact: Kristen Woodward
kwoodwar@fhcrc.org
206-667-5095
Fred Hutchinson Cancer Research Center
Source:Eurekalert

Related medicine news :

1. FDA Seeks Reduction in Radiation From Medical Scans
2. For Some Breast Cancer Patients, Shorter Radiation Works Well
3. Short-term radiation therapy successful on breast cancer
4. ASCROs Response to NY Times Articles on Radiation Therapy Incidents
5. Imaging manufacturers: Plan to reduce unnecessary radiation exposure and medical errors
6. Roseville Radiation Oncology Center (ROC) Redefines Efficiency With Elekta VMAT Radiotherapy Treatments
7. New cardiac CT technology drastically reduces patient radiation exposure
8. New Heart CT Scans Deliver Far Less Radiation: Study
9. Accelerated radiation therapy reduces toxicity in patients with advanced head and neck cancers
10. Delaying post-surgical radiation increases risk of breast cancer recurrence in older women
11. Radiation Most Effective Soon After Breast Cancer Surgery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary of ... award to iHire in recognition of their exemplary accomplishments in worksite health promotion. , ... Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle Cell ... pain and the benefits of holistic treatments, Serenity Recovery Center of Marne, ... Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the red blood ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda ... orthodontic treatment. Dr. Cheng has extensive experience with all areas of orthodontics, including ... accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. ...
(Date:6/24/2016)... Georgia (PRWEB) , ... June 24, 2016 , ... ... awards today at the Clinical Decision Making in Emergency Medicine conference in Ponte ... have authored journal articles published in Emergency Medicine Practice and Pediatric ...
(Date:6/24/2016)... ... June 24, 2016 , ... National recruitment firm Slone Partners ... with extensive sequencing and genomics experience, as Vice President of North American Capital Sales ... be responsible for leading the sales team in the commercialization of the HTG EdgeSeq ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Research and ... Excipients Market by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), ... Topical, Coating, Parenteral) - Global Forecast to 2021" ... The global pharmaceutical excipients market is projected ... CAGR of 6.1% in the forecast period 2016 to ...
(Date:6/23/2016)... ANGELES , June 23, 2016 ... CAPR ), a biotechnology company focused ... therapeutics, today announced that patient enrollment in its ... in Duchenne) has exceeded 50% of its 24-patient ... enrollment in the third quarter of 2016, and ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 /PRNewswire/ ... Diabetes Tomorrow,s Leaders Scholarship is any indication, the future ... today online at www.diabetesscholars.org by the Diabetes ... stand in the way of academic and community service ... scholarship program since 2012, and continues to advocate for ...
Breaking Medicine Technology: