Navigation Links
Radiation after lumpectomy helps prevent need for mastectomy in early stage breast cancer
Date:8/12/2012

Contrary to clinical recommendations, older women with early stage breast cancer may want to undergo radiation after lumpectomy to help ensure that they will not need a mastectomy in the future. That is the conclusion of a new study published early online in CANCER, a peer-reviewed journal of the American Cancer Society. The findings indicate that current thinking on the risks and benefits of radiation for early stage breast cancer in older women may be inaccurate.

National treatment guidelines state that older women with early stage breast cancer that has not spread to the lymph nodes and that is driven by estrogen in the body can be treated with lumpectomy and estrogen blockers without the need for radiation. Benjamin Smith, MD, of The University of Texas MD Anderson Cancer Center in Houston, and his colleagues evaluated information on 7,403 women aged 70 to 79 years who were treated with lumpectomy for such breast cancers between 1992 and 2002 and whose data were contained in the Surveillance, Epidemiology, and End Results-Medicare database, which links cancer registry information to a master file of Medicare enrollment. Approximately 88 percent of these women received radiation after their lumpectomy.

When the investigators looked to see what happened to these women after their breast cancer was treated, they found that within 10 years after treatment, 6.3 percent of women who did not get radiation eventually had their breast removed by mastectomy, compared with only 3.2 percent of women who received radiation. The reasons for mastectomy are not reported by this dataset, but the most likely reason for mastectomy in this patient group is recurrence of cancer in the breast. The researchers were also able to identify which women were more and less likely to benefit from radiation. Specifically, radiation did not seem to benefit women ages 75 to 79 years with non-high grade tumors (which contain cells that look only moderately abnormal under a microscope), suggesting that this group can probably skip radiation. Patients with high grade tumors (which contain very abnormal-looking cells), regardless of age, seemed to derive the most benefit from radiation.

"These data are important because they suggest that radiation is likely of some benefit to certain women where national guidelines say that radiation is not needed," said Dr. Smith. "Our data could be helpful to women when they decide whether or not to undergo radiation," he added.


'/>"/>

Contact: Jennifer Beal
sciencenewsroom@wiley.com
44-012-437-70633
Wiley
Source:Eurekalert

Related medicine news :

1. Antibody therapy prevents gastrointestinal damage following radiation exposure in mice
2. Diagnostic Scans Tied to Radiation Risk for Gastro Patients
3. CT Scans Deliver More Radiation to Obese People: Study
4. Intensity Modulated Radiation Therapy optimal for localized prostate cancer
5. Study examines adverse effects among different radiation therapies for prostate cancer
6. Chemo + Radiation Best for Bladder Cancer, Study Finds
7. Use of dedicated pediatric imaging departments for pediatric CT reduces radiation dose
8. APBI associated with more mastectomies, toxicities, complications, compared to traditional radiation
9. Cone beam CT proves better for visualizing some causes of hearing loss at half the radiation dose
10. Highly targeted irradiation as good as whole breast radiotherapy in early stage cancer
11. Novel biomarkers reveal evidence of radiation exposure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... that was developed to enhance the health of felines. The formula is all-natural and ... main herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are ...
(Date:6/25/2016)... ... , ... Austin residents seeking Mohs surgery services, can now turn to Dr. ... Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization to include ... in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction of Glenn ...
(Date:6/25/2016)... CA (PRWEB) , ... June 25, 2016 , ... As ... with Magna Cum Laude and his M.D from the David Geffen School of Medicine ... and returned to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June 14 ... The article goes on to state that individuals are now more comfortable seeking to ... operations such as calf and cheek reduction. The Los Angeles area medical group, Beverly ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association (PHA) ... will receive two significant new grants to support its work to advance research ... anniversary by recognizing patients, medical professionals and scientists for their work in fighting ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016  Collagen Matrix, ... design, development and manufacturing of collagen and mineral ... announced today that Bill Messer has ... Marketing to further leverage the growing portfolio of ... devices. Bill joins the Collagen Matrix ...
(Date:6/24/2016)... -- The Academy of Managed Care Pharmacy (AMCP) today ... allow biopharmaceutical companies to more easily share health care ... coverage decisions, a move that addresses the growing need ... The recommendations address restrictions in the sharing of product ... a prohibition that hinders decision makers from accessing HCEI ...
(Date:6/24/2016)... 2016   Pulmatrix, Inc ., (NASDAQ: ... drugs, announced today that it was added to the ... its comprehensive set of U.S. and global equity indexes ... important milestone for Pulmatrix," said Chief Executive Officer ... our progress in developing drugs for crucial unmet medical ...
Breaking Medicine Technology: